FXJ1A_XENLA
ID FXJ1A_XENLA Reviewed; 439 AA.
AC Q708W2; Q6DCY6; Q9PS84;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Forkhead box protein J1-A;
DE Short=FoxJ1-A;
DE Short=FoxJ1a;
DE Short=xFoxJ1;
DE AltName: Full=Forkhead protein 5;
DE Short=xFKH5;
GN Name=foxj1-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAE76650.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Tadpole {ECO:0000269|PubMed:14986136};
RX PubMed=14986136; DOI=10.1007/s00427-004-0391-7;
RA Pohl B.S., Knoechel W.;
RT "Isolation and developmental expression of Xenopus FoxJ1 and FoxK1.";
RL Dev. Genes Evol. 214:200-205(2004).
RN [2] {ECO:0000312|EMBL:AAH77846.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH77846.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 124-185, AND TISSUE SPECIFICITY.
RC TISSUE=Embryo {ECO:0000269|PubMed:7586752};
RX PubMed=7586752; DOI=10.1002/dvg.1020170203;
RA Dirksen M.-L., Jamrich M.;
RT "Differential expression of fork head genes during early Xenopus and
RT zebrafish development.";
RL Dev. Genet. 17:107-116(1995).
RN [4] {ECO:0000305}
RP REVIEW.
RX PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA Pohl B.S., Knoechel W.;
RT "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT Xenopus development.";
RL Gene 344:21-32(2005).
RN [5]
RP FUNCTION.
RX PubMed=19011629; DOI=10.1038/ng.267;
RA Stubbs J.L., Oishi I., Izpisua Belmonte J.C., Kintner C.;
RT "The forkhead protein Foxj1 specifies node-like cilia in Xenopus and
RT zebrafish embryos.";
RL Nat. Genet. 40:1454-1460(2008).
CC -!- FUNCTION: Key transcription factor required for motile ciliogenesis.
CC Activates genes essential for motile cilia formation and function.
CC Required for ciliogenesis in multiciliated cells.
CC {ECO:0000269|PubMed:15656969, ECO:0000269|PubMed:19011629}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in two independent areas of stage 10-11
CC embryos; in the dorsal blastopore lip (Spemann organizer) and shortly
CC after in the ectodermal cells of the animal cap. As development
CC proceeds, cells of the animal cap contribute to the epidermis and show
CC a spotty pattern, which suggests expression in ciliated epidermal
CC cells. Distribution of these cells is uniform in the trunk area of the
CC embryo but more random in the head, being practically absent in the
CC cement gland and olfactory placode. The spotted pattern becomes more
CC dispersed as embryos grow in size. Due to cell movements during
CC gastrulation, expression in the dorsal lip becomes located in the
CC dorsal midline with expression restricted to the neuroectoderm.
CC Expressed transiently in cells of the newly formed neural floor plate
CC in the tail of older tadpoles. {ECO:0000269|PubMed:14986136,
CC ECO:0000269|PubMed:7586752}.
CC -!- DEVELOPMENTAL STAGE: Expression begins during gastrulation, increases
CC continuously until stage 26 and then becomes slightly down-regulated
CC during the following stages. {ECO:0000269|PubMed:14986136}.
CC -!- SIMILARITY: Belongs to the FOXJ1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH77846.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ609390; CAE76650.1; -; mRNA.
DR EMBL; BC077846; AAH77846.1; ALT_INIT; mRNA.
DR RefSeq; NP_001083646.1; NM_001090177.1.
DR AlphaFoldDB; Q708W2; -.
DR SMR; Q708W2; -.
DR GeneID; 399039; -.
DR KEGG; xla:399039; -.
DR CTD; 399039; -.
DR Xenbase; XB-GENE-6254646; foxj1.S.
DR OMA; SALMTQE; -.
DR OrthoDB; 1270467at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 399039; Expressed in neurula embryo and 7 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Activator; Cilium biogenesis/degradation; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..439
FT /note="Forkhead box protein J1-A"
FT /id="PRO_0000250442"
FT DNA_BIND 124..218
FT /note="Fork-head"
FT /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT ProRule:PRU00089"
FT REGION 273..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 49195 MW; 12D3CA93CE17045C CRC64;
MFDLPRAAPL DMADSWLTFQ AEEEQGQESF SSSVNLDDSL TSLQWLQEFS ILNSNEGKTP
SSSGDSHGYR QLSGAPCSPL AADPACLGMP HTPGKPISSS TSRASHLGLQ PMEEIDYKTN
PHVKPPYSYA TLICMAMQAS KKTKITLSAI YNWITDNFCY FRHADPTWQN SIRHNLSLNK
CFMKVPREKD EPGKGGFWKI DPQYADRLIN GAMKKRRLPP VQIHPAFASA QAAASSDSKR
GSAWQMSVNS ESHQLLKAFE EITNEQGWNP LGEHGWNSIS DGKSHKRKQP LPKRMFKAPR
LSSSPMLSQE EQTELGSLKG DFDWEVIFDS SINGFNFSAF EDLEVTPPLS PVTRSVDLTV
HGKHIDCPQQ WYPMGQDHAV AQNSLDFDET LLATSFLQHP WEENRNDYLS NSANIEQLFD
LNEAFPAELN DWSSLGSYI
