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FXJ1B_DANRE
ID   FXJ1B_DANRE             Reviewed;         442 AA.
AC   F1R8Z9; Q5PRB5;
DT   29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Forkhead box protein J1-B {ECO:0000305};
GN   Name=foxj1b; Synonyms=foxj1.2 {ECO:0000303|PubMed:18956329};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium {ECO:0000312|EMBL:AAH86726.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=18956329; DOI=10.1387/ijdb.072477ea;
RA   Aamar E., Dawid I.B.;
RT   "Isolation and expression analysis of foxj1 and foxj1.2 in zebrafish
RT   embryos.";
RL   Int. J. Dev. Biol. 52:985-991(2008).
RN   [4]
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=19011630; DOI=10.1038/ng.263;
RA   Yu X., Ng C.P., Habacher H., Roy S.;
RT   "Foxj1 transcription factors are master regulators of the motile ciliogenic
RT   program.";
RL   Nat. Genet. 40:1445-1453(2008).
RN   [5]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=19284996; DOI=10.1016/j.bbrc.2009.01.111;
RA   Tian T., Zhao L., Zhang M., Zhao X., Meng A.;
RT   "Both foxj1a and foxj1b are implicated in left-right asymmetric development
RT   in zebrafish embryos.";
RL   Biochem. Biophys. Res. Commun. 380:537-542(2009).
RN   [6]
RP   FUNCTION.
RX   PubMed=19840756; DOI=10.1016/s1673-8527(08)60150-2;
RA   Tian T., Zhao L., Zhao X., Zhang M., Meng A.;
RT   "A zebrafish gene trap line expresses GFP recapturing expression pattern of
RT   foxj1b.";
RL   J. Genet. Genomics 36:581-589(2009).
CC   -!- FUNCTION: Key transcription factor required for motile ciliogenesis.
CC       Activates genes essential for motile cilia formation and function.
CC       {ECO:0000269|PubMed:19011630, ECO:0000269|PubMed:19840756}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
CC   -!- DEVELOPMENTAL STAGE: Strongly expressed in the shield, the floor plate
CC       in early somitogenesis, the posterior neural plate, the otic vesicles
CC       and later in the otoliths, the pronephric ducts, diencephalon,
CC       olfactory pits, briefly in the trigeminal ganglion, and in an anterior
CC       brain region that overlaps the pineal gland and later corresponds to
CC       the anterior tectal ventricle. {ECO:0000269|PubMed:18956329,
CC       ECO:0000269|PubMed:19011630}.
CC   -!- DISRUPTION PHENOTYPE: Randomization of the left-right body.
CC       {ECO:0000269|PubMed:19284996}.
CC   -!- SIMILARITY: Belongs to the FOXJ1 family. {ECO:0000305}.
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DR   EMBL; CR318663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU207309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC086726; AAH86726.1; -; mRNA.
DR   EMBL; BC165812; AAI65812.1; -; mRNA.
DR   RefSeq; NP_001008648.1; NM_001008648.1.
DR   RefSeq; XP_009304887.1; XM_009306612.1.
DR   AlphaFoldDB; F1R8Z9; -.
DR   SMR; F1R8Z9; -.
DR   STRING; 7955.ENSDARP00000107064; -.
DR   PaxDb; F1R8Z9; -.
DR   Ensembl; ENSDART00000126676; ENSDARP00000107064; ENSDARG00000088290.
DR   Ensembl; ENSDART00000181942; ENSDARP00000145705; ENSDARG00000088290.
DR   GeneID; 494105; -.
DR   KEGG; dre:494105; -.
DR   CTD; 494105; -.
DR   ZFIN; ZDB-GENE-041212-76; foxj1b.
DR   eggNOG; KOG2294; Eukaryota.
DR   GeneTree; ENSGT00940000164514; -.
DR   HOGENOM; CLU_050055_1_0_1; -.
DR   InParanoid; F1R8Z9; -.
DR   OMA; HQSYGYM; -.
DR   OrthoDB; 1270467at2759; -.
DR   PhylomeDB; F1R8Z9; -.
DR   TreeFam; TF333250; -.
DR   PRO; PR:F1R8Z9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 12.
DR   Bgee; ENSDARG00000088290; Expressed in testis and 46 other tissues.
DR   ExpressionAtlas; F1R8Z9; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0060088; P:auditory receptor cell stereocilium organization; IMP:ZFIN.
DR   GO; GO:0060271; P:cilium assembly; IMP:ZFIN.
DR   GO; GO:0007368; P:determination of left/right symmetry; IMP:ZFIN.
DR   GO; GO:0003146; P:heart jogging; IMP:ZFIN.
DR   GO; GO:0001947; P:heart looping; IMP:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cilium biogenesis/degradation; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..442
FT                   /note="Forkhead box protein J1-B"
FT                   /id="PRO_0000430815"
FT   DNA_BIND        139..233
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          73..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        118
FT                   /note="H -> Q (in Ref. 2; AAH86726/AAI65812)"
FT   CONFLICT        275
FT                   /note="V -> D (in Ref. 2; AAH86726/AAI65812)"
SQ   SEQUENCE   442 AA;  50006 MW;  DF8C1544716A1942 CRC64;
     MPVLMSPEIA NKFKEKWLML HPEDQDNVSG SVHFDDSLTS LHWLQNFSIL SANPERTPSS
     GCHPQHLFYY KNQLGGTDSP SSPPAGDTAA TGMPQTPGNP TTSCSSLANP YALQQAGHYI
     TGQTNPAEEI DYKTNRHVKP PYSYATLICM AMQASNKTKI TLSAIYSWIT ENFCYYRYAE
     PSWQNSIRHN LSLNKCFMKV PRQKDEPGKG GFWQIDPQYA DMFVNGVFKR RRMPATNFNT
     QRQSKMLSSP SSSYTSQCNQ QMGMGHFQGN KRKQVFPKRG NKLARISKSP LLTSDIKTSD
     VLRGDFDLAS VFDDVLSGND STFEDLDINT ALSSLGCEME PSSQIHNQSG YSNEDEQACA
     YLEANGIIGC NMEDFHHQQH HQQAQVHPQY YEGMFSDQQN QQHPWEIKEE AQPVPLSLDH
     GYAFCEGFFS EMQLWERGES YM
 
 
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