ID   FXJ1B_XENLA             Reviewed;         439 AA.
AC   Q708W1;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Forkhead box protein J1-B;
DE            Short=FoxJ1-B;
DE            Short=FoxJ1b;
DE            Short=xFoxJ1';
GN   Name=foxj1-b; Synonyms=foxj1' {ECO:0000312|EMBL:CAE76651.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:CAE76651.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Tadpole {ECO:0000269|PubMed:14986136};
RX   PubMed=14986136; DOI=10.1007/s00427-004-0391-7;
RA   Pohl B.S., Knoechel W.;
RT   "Isolation and developmental expression of Xenopus FoxJ1 and FoxK1.";
RL   Dev. Genes Evol. 214:200-205(2004).
RN   [2] {ECO:0000305}
RP   REVIEW.
RX   PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA   Pohl B.S., Knoechel W.;
RT   "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT   Xenopus development.";
RL   Gene 344:21-32(2005).
CC   -!- FUNCTION: Key transcription factor required for motile ciliogenesis.
CC       Activates genes essential for motile cilia formation and function.
CC       {ECO:0000250|UniProtKB:Q708W2, ECO:0000269|PubMed:15656969}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FOXJ1 family. {ECO:0000305}.
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DR   EMBL; AJ609391; CAE76651.1; -; mRNA.
DR   RefSeq; NP_001083644.1; NM_001090175.1.
DR   AlphaFoldDB; Q708W1; -.
DR   SMR; Q708W1; -.
DR   GeneID; 399038; -.
DR   KEGG; xla:399038; -.
DR   CTD; 399038; -.
DR   Xenbase; XB-GENE-856300; foxj1.L.
DR   OrthoDB; 1270467at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 399038; Expressed in neurula embryo and 6 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cilium biogenesis/degradation; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..439
FT                   /note="Forkhead box protein J1-B"
FT                   /id="PRO_0000250443"
FT   DNA_BIND        124..218
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00089"
SQ   SEQUENCE   439 AA;  49020 MW;  5D4F8EA9A3F95860 CRC64;
     MFDLPTVAPL DMEDSWVTFQ AEGDQGQDSF SSSVNLDDSL TSLQWLQEFS ILNANVGKTP
     SSSGDSHGYR HLSGAPCSPL AADPACLGMP HTPGKPISSS TSRASHLGLQ PMEEIDYKTN
     PHVKPPYSYA TLICMAMQAS KKTKITLSAI YKWITDNFCY FRHADPTWQN SIRHNLSLNK
     CFIKVPREKD EPGKGGFWKI DPQYADRLMN GAMKKRRLPP VQIHPAFASA QAAASSNGNR
     ASAWQMSVNS ESHKLLKEFE EITSEQSWNA LGEHGWNAIS DGKSHKRKQP LPKRMFKAPR
     LSSSPMLSQE EQTELGSLKG DFDWEVIFDS SINGVNFSAF EDLEVTPPLS PVSRSVDLTV
     HGKHIDCPQQ WYPMGQDQAV AQNSLDFDET FLATSFLQHP WEENRNDYLS NSANIEQLFD
     LNDAFPAELN DWPALGSYI