FXL12_BOVIN
ID FXL12_BOVIN Reviewed; 326 AA.
AC Q32PG9;
DT 14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=F-box/LRR-repeat protein 12;
DE AltName: Full=F-box and leucine-rich repeat protein 12;
GN Name=FBXL12;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. Mediates the
CC polyubiquitination and proteasomal degradation of CAMK1 leading to
CC disruption of cyclin D1/CDK4 complex assembly which results in G1 cell
CC cycle arrest in lung epithelia (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Interacts with SKP1 and CUL1. {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC108120; AAI08121.1; -; mRNA.
DR RefSeq; NP_001035690.1; NM_001040600.2.
DR AlphaFoldDB; Q32PG9; -.
DR SMR; Q32PG9; -.
DR STRING; 9913.ENSBTAP00000035085; -.
DR PaxDb; Q32PG9; -.
DR PRIDE; Q32PG9; -.
DR Ensembl; ENSBTAT00000035207; ENSBTAP00000035085; ENSBTAG00000025148.
DR GeneID; 617304; -.
DR KEGG; bta:617304; -.
DR CTD; 54850; -.
DR VEuPathDB; HostDB:ENSBTAG00000025148; -.
DR VGNC; VGNC:52772; FBXL12.
DR eggNOG; KOG1947; Eukaryota.
DR GeneTree; ENSGT00390000003354; -.
DR InParanoid; Q32PG9; -.
DR OMA; SCLAMPK; -.
DR OrthoDB; 1046098at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000025148; Expressed in thymus and 103 other tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IBA:GO_Central.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF12937; F-box-like; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..326
FT /note="F-box/LRR-repeat protein 12"
FT /id="PRO_0000259959"
FT DOMAIN 1..47
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REPEAT 51..78
FT /note="LRR 1"
FT REPEAT 86..111
FT /note="LRR 2"
FT REPEAT 161..185
FT /note="LRR 3"
FT REPEAT 186..211
FT /note="LRR 4"
FT REPEAT 212..236
FT /note="LRR 5"
FT REPEAT 237..261
FT /note="LRR 6"
FT REPEAT 266..291
FT /note="LRR 7"
SQ SEQUENCE 326 AA; 37126 MW; F6A85EA80D260FE5 CRC64;
MATFADLPDS VLLEIFSYLP VRDRIRISRV CHHWKKLVDD RWLWRHVDLT LYTMRPKVMW
HLLRRYMASR LHSLRMGGYL FSGSQAPQLS PALMRALGQK CPNLKRLCLH VANLSMVPIT
SLPCTLRTLE LHSCEISMAW LHKEQDPTVL PLLECIVLDR VPAFRDEHLQ GLTRFRALRS
LVLGGTYRVT ETGLDMGLQE LNYLQRLEVL GCTLSADSTL LAISRHLRDV RKIRLTVRGL
SAPGLSVLEG MPALESLCLL GPLVTPEMPS PQEILASCLT MPKLRVLELQ GLGWEGQEAE
RILSKGLPHC MVIVRALPKE SMDWWM
