ID   FXL14_BOVIN             Reviewed;         400 AA.
AC   Q17R01;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=F-box/LRR-repeat protein 14;
DE   AltName: Full=F-box and leucine-rich repeat protein 14;
GN   Name=FBXL14;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of some SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14)
CC       complex acts by mediating ubiquitination and subsequent degradation of
CC       SNAI1 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) ubiquitin-protein ligase
CC       complex. Interacts with SKP1 and CUL1. Interacts with SNAI1; the
CC       interaction requires the phosphorylation of the two serine residues in
CC       the substrate destruction motif D-S-G-X(2,3,4)-S (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; BC118093; AAI18094.1; -; mRNA.
DR   RefSeq; NP_001069415.1; NM_001075947.1.
DR   RefSeq; XP_005207331.1; XM_005207274.3.
DR   AlphaFoldDB; Q17R01; -.
DR   SMR; Q17R01; -.
DR   STRING; 9913.ENSBTAP00000010237; -.
DR   PaxDb; Q17R01; -.
DR   PRIDE; Q17R01; -.
DR   GeneID; 531211; -.
DR   KEGG; bta:531211; -.
DR   CTD; 144699; -.
DR   eggNOG; KOG1947; Eukaryota.
DR   HOGENOM; CLU_016072_7_0_1; -.
DR   InParanoid; Q17R01; -.
DR   OrthoDB; 1282076at2759; -.
DR   TreeFam; TF313434; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; ISS:UniProtKB.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF13516; LRR_6; 5.
DR   SMART; SM00367; LRR_CC; 11.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Leucine-rich repeat; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..400
FT                   /note="F-box/LRR-repeat protein 14"
FT                   /id="PRO_0000285083"
FT   DOMAIN          2..48
FT                   /note="F-box"
FT   REPEAT          144..163
FT                   /note="LRR 1"
FT   REPEAT          170..191
FT                   /note="LRR 2"
FT   REPEAT          203..225
FT                   /note="LRR 3"
FT   REPEAT          229..250
FT                   /note="LRR 4"
FT   REPEAT          254..275
FT                   /note="LRR 5"
FT   REGION          2..48
FT                   /note="Required for down-regulation of SNAI1"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   400 AA;  43864 MW;  E0B297E4B4F83C22 CRC64;
     METHISCLFP ELLAMIFGYL DVRDKGRAAQ VCTAWRDAAY HKSVWRGVEA KLHLRRANPS
     LFPSLQARGI RRVQILSLRR SLSYVIQGMA NIESLNLSGC YNLTDNGLGH AFVQEIGSLR
     ALNLSLCKQI TDSSLGRIAQ YLKGLEVLEL GGCSNITNTG LLLIAWGLQR LKSLNLRSCR
     HLSDVGIGHL AGMTRSAAEG CLGLEQLTLQ DCQKLTDLSL KHISRGLTGL RLLNLSFCGG
     ISDAGLLHLS HMGSLRSLNL RSCDNISDTG IMHLAMGSLR LSGLDVSFCD KVGDQSLAYI
     AQGLDGLKSL SLCSCHISDD GINRMVRQMH GLRTLNIGQC VRITDKGLEL IAEHLSQLTG
     IDLYGCTRIT KRGLERITQL PCLKVLNLGL WQMTDSEKVR