ID   FXL15_SALSA             Reviewed;         292 AA.
AC   B5X441;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=F-box/LRR-repeat protein 15;
GN   Name=fbxl15;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box
CC       protein) E3 ubiquitin-protein ligase complex which mediates the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. Acts as a positive regulator of the BMP signaling pathway).
CC       Required for dorsal/ventral pattern formation (By similarity.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase
CC       complex SCF(FBXL15). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FBXL15 family. {ECO:0000305}.
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DR   EMBL; BT045810; ACI34072.1; -; mRNA.
DR   RefSeq; NP_001133881.1; NM_001140409.1.
DR   RefSeq; XP_014010790.1; XM_014155315.1.
DR   AlphaFoldDB; B5X441; -.
DR   SMR; B5X441; -.
DR   STRING; 8030.ENSSSAP00000045511; -.
DR   GeneID; 100195380; -.
DR   GeneID; 106577353; -.
DR   KEGG; sasa:100195380; -.
DR   KEGG; sasa:106577353; -.
DR   CTD; 100195380; -.
DR   OMA; HCHNVAE; -.
DR   OrthoDB; 1154571at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000087266; Chromosome ssa18.
DR   Bgee; ENSSSAG00000047107; Expressed in ovary and 16 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0030282; P:bone mineralization; ISS:UniProtKB.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
DR   GO; GO:0000086; P:G2/M transition of mitotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF00646; F-box; 1.
DR   Pfam; PF13516; LRR_6; 1.
DR   SMART; SM00367; LRR_CC; 6.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Leucine-rich repeat; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..292
FT                   /note="F-box/LRR-repeat protein 15"
FT                   /id="PRO_0000410908"
FT   DOMAIN          12..59
FT                   /note="F-box"
FT   REPEAT          134..155
FT                   /note="LRR 1"
FT   REPEAT          160..181
FT                   /note="LRR 2"
FT   REPEAT          186..207
FT                   /note="LRR 3"
FT   REPEAT          212..233
FT                   /note="LRR 4"
FT   REPEAT          238..259
FT                   /note="LRR 5"
SQ   SEQUENCE   292 AA;  33172 MW;  C35C91CEE14B96C6 CRC64;
     MDAETECCKC HLLDLPWEDV LVTHIFCYLP LRQLVRLQRV SKQFYALIQV YLANCRTFDL
     TQIGPSLPKE AFCNILRDNK VLQNLSVQNC SDWVTDTELL PVIGQNQHLL RVDMRGCDRL
     TRHSLVAVSL SCTHLQYLGL AHCEWVDSLS IRSLADHCGG LRSIDLTACR QLKDEAICYL
     SKKCLKMRSL SVAVNANITD VSVEEVAKNC RELEQLDLTG CLRVRNDSIR TVAEYCPKLQ
     SLKVNHCHNV TESSLDPLRK RNVEIDVEPP LQRALVLLQD VVGFAPFINL QI