ID   FXL15_XENLA             Reviewed;         292 AA.
AC   Q7SZ73;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=F-box/LRR-repeat protein 15;
GN   Name=fbxl15;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box
CC       protein) E3 ubiquitin-protein ligase complex which mediates the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. Acts as a positive regulator of the BMP signaling pathway).
CC       Required for dorsal/ventral pattern formation (By similarity.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase
CC       complex SCF(FBXL15). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FBXL15 family. {ECO:0000305}.
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DR   EMBL; BC053821; AAH53821.1; -; mRNA.
DR   RefSeq; NP_001079747.1; NM_001086278.1.
DR   AlphaFoldDB; Q7SZ73; -.
DR   SMR; Q7SZ73; -.
DR   DNASU; 379436; -.
DR   GeneID; 379436; -.
DR   KEGG; xla:379436; -.
DR   CTD; 379436; -.
DR   Xenbase; XB-GENE-973064; fbxl15.L.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 379436; Expressed in camera-type eye and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0030282; P:bone mineralization; ISS:UniProtKB.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
DR   GO; GO:0000086; P:G2/M transition of mitotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF00646; F-box; 1.
DR   Pfam; PF13516; LRR_6; 1.
DR   SMART; SM00367; LRR_CC; 6.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Leucine-rich repeat; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..292
FT                   /note="F-box/LRR-repeat protein 15"
FT                   /id="PRO_0000410909"
FT   DOMAIN          12..59
FT                   /note="F-box"
FT   REPEAT          134..155
FT                   /note="LRR 1"
FT   REPEAT          160..181
FT                   /note="LRR 2"
FT   REPEAT          186..207
FT                   /note="LRR 3"
FT   REPEAT          212..233
FT                   /note="LRR 4"
FT   REPEAT          238..259
FT                   /note="LRR 5"
SQ   SEQUENCE   292 AA;  33013 MW;  B7450C5EA6E48F97 CRC64;
     MAKDEDNSRV HLLDLPWEDV LVPHILSYLP LRHILSLQRV SKPFHSLVHI YLCNCRHFDS
     TQLGPQLPKT TFSELLKNNT VLQKLDLQSC SDWLTDKELL PIIGQNHHLT YINLNSCGQL
     TRQSLVAISL SCPHLQNICL GHCDWVDCLS MRSLADHCKC LEAIDLTACR QLKDDAISYL
     VQKSTRLKSL SLAVNANISD IAVEETAKSC RDLEHLDLTG CLRVKNDSIR TLAEYCNNLK
     SLKVKHCHNV TESSLGNLRK REVVLDVEPP LQRALVLLQD VVGFAPFINL QI