ID   FXL15_XENTR             Reviewed;         292 AA.
AC   Q5XGC0;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=F-box/LRR-repeat protein 15;
GN   Name=fbxl15; ORFNames=TGas057g02.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box
CC       protein) E3 ubiquitin-protein ligase complex which mediates the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. Acts as a positive regulator of the BMP signaling pathway).
CC       Required for dorsal/ventral pattern formation (By similarity.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase
CC       complex SCF(FBXL15). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FBXL15 family. {ECO:0000305}.
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DR   EMBL; CR762261; CAJ82498.1; -; mRNA.
DR   EMBL; BC084522; AAH84522.1; -; mRNA.
DR   RefSeq; NP_001011123.1; NM_001011123.2.
DR   RefSeq; XP_012821959.1; XM_012966505.2.
DR   AlphaFoldDB; Q5XGC0; -.
DR   SMR; Q5XGC0; -.
DR   STRING; 8364.ENSXETP00000031072; -.
DR   PaxDb; Q5XGC0; -.
DR   GeneID; 496536; -.
DR   KEGG; xtr:496536; -.
DR   CTD; 79176; -.
DR   Xenbase; XB-GENE-973058; fbxl15.
DR   eggNOG; KOG1947; Eukaryota.
DR   HOGENOM; CLU_065717_2_0_1; -.
DR   InParanoid; Q5XGC0; -.
DR   OMA; CATHICI; -.
DR   OrthoDB; 1154571at2759; -.
DR   TreeFam; TF326769; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0030282; P:bone mineralization; ISS:UniProtKB.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
DR   GO; GO:0000086; P:G2/M transition of mitotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF00646; F-box; 1.
DR   SMART; SM00367; LRR_CC; 6.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Leucine-rich repeat; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..292
FT                   /note="F-box/LRR-repeat protein 15"
FT                   /id="PRO_0000410910"
FT   DOMAIN          12..59
FT                   /note="F-box"
FT   REPEAT          134..155
FT                   /note="LRR 1"
FT   REPEAT          160..181
FT                   /note="LRR 2"
FT   REPEAT          186..207
FT                   /note="LRR 3"
FT   REPEAT          212..233
FT                   /note="LRR 4"
FT   REPEAT          238..259
FT                   /note="LRR 5"
SQ   SEQUENCE   292 AA;  32983 MW;  8A1DD81304F26E5F CRC64;
     MAKDEDNSSV HLLDLPWEDV LVPHILRNLP LRHILSLQRV SKPFQSLVHL YLANCRHFDS
     TQLGSQLPKS TFSELLRNNT VLQKLDLQSC CDWLTDKELL PVIGQNHHLI HINLNSCGQL
     TRQSLVAISL SCPHLQNICL GHCEWVDCLS LRSLVDHCKC LEAIDLTACR QLKDDTISYL
     VQKSTRLKSL SLAVNANISD IAVEETAKNC RDLEHLDLTG CLRVKNDSIR TLAEYCTKLK
     SLKVKHCHNV TESSLGNLRK REVVLDVEPP LQRALVLLQD VVGFGPFINL QI