FXL16_HUMAN
ID FXL16_HUMAN Reviewed; 479 AA.
AC Q8N461; B3KR59; D3DU60; Q2MHR2; Q96S14; Q9UJI0;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=F-box/LRR-repeat protein 16;
DE AltName: Full=F-box and leucine-rich repeat protein 16;
GN Name=FBXL16; Synonyms=C16orf22, FBL16;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT PRO-429.
RX PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C.,
RA Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.;
RT "Sequence, structure and pathology of the fully annotated terminal 2 Mb of
RT the short arm of human chromosome 16.";
RL Hum. Mol. Genet. 10:339-352(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT PRO-429.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SKP1 and CUL1. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N461-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N461-2; Sequence=VSP_056996;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK61245.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK091054; BAG52271.1; -; mRNA.
DR EMBL; AE006464; AAK61245.1; ALT_SEQ; Genomic_DNA.
DR EMBL; Z92544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z97653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471112; EAW85749.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85750.1; -; Genomic_DNA.
DR EMBL; BC036680; AAH36680.1; -; mRNA.
DR CCDS; CCDS10421.1; -. [Q8N461-1]
DR RefSeq; NP_699181.2; NM_153350.3. [Q8N461-1]
DR AlphaFoldDB; Q8N461; -.
DR SMR; Q8N461; -.
DR BioGRID; 126979; 30.
DR IntAct; Q8N461; 13.
DR MINT; Q8N461; -.
DR STRING; 9606.ENSP00000380746; -.
DR iPTMnet; Q8N461; -.
DR PhosphoSitePlus; Q8N461; -.
DR BioMuta; FBXL16; -.
DR DMDM; 116242480; -.
DR EPD; Q8N461; -.
DR jPOST; Q8N461; -.
DR MassIVE; Q8N461; -.
DR MaxQB; Q8N461; -.
DR PaxDb; Q8N461; -.
DR PeptideAtlas; Q8N461; -.
DR PRIDE; Q8N461; -.
DR ProteomicsDB; 3581; -.
DR ProteomicsDB; 71888; -. [Q8N461-1]
DR Antibodypedia; 22839; 129 antibodies from 26 providers.
DR DNASU; 146330; -.
DR Ensembl; ENST00000324361.9; ENSP00000318674.5; ENSG00000127585.12. [Q8N461-1]
DR Ensembl; ENST00000397621.6; ENSP00000380746.1; ENSG00000127585.12. [Q8N461-1]
DR Ensembl; ENST00000562563.1; ENSP00000455217.1; ENSG00000127585.12. [Q8N461-2]
DR GeneID; 146330; -.
DR KEGG; hsa:146330; -.
DR MANE-Select; ENST00000397621.6; ENSP00000380746.1; NM_153350.4; NP_699181.2.
DR UCSC; uc002cjb.4; human. [Q8N461-1]
DR CTD; 146330; -.
DR DisGeNET; 146330; -.
DR GeneCards; FBXL16; -.
DR HGNC; HGNC:14150; FBXL16.
DR HPA; ENSG00000127585; Tissue enriched (brain).
DR MIM; 609082; gene.
DR neXtProt; NX_Q8N461; -.
DR OpenTargets; ENSG00000127585; -.
DR PharmGKB; PA25536; -.
DR VEuPathDB; HostDB:ENSG00000127585; -.
DR eggNOG; KOG1947; Eukaryota.
DR GeneTree; ENSGT00940000159138; -.
DR HOGENOM; CLU_027026_1_0_1; -.
DR InParanoid; Q8N461; -.
DR OMA; FWAGLMP; -.
DR OrthoDB; 1282076at2759; -.
DR PhylomeDB; Q8N461; -.
DR TreeFam; TF324260; -.
DR PathwayCommons; Q8N461; -.
DR Reactome; R-HSA-8951664; Neddylation.
DR Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR SignaLink; Q8N461; -.
DR BioGRID-ORCS; 146330; 4 hits in 1112 CRISPR screens.
DR ChiTaRS; FBXL16; human.
DR GenomeRNAi; 146330; -.
DR Pharos; Q8N461; Tdark.
DR PRO; PR:Q8N461; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8N461; protein.
DR Bgee; ENSG00000127585; Expressed in Brodmann (1909) area 46 and 166 other tissues.
DR Genevisible; Q8N461; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13516; LRR_6; 2.
DR SMART; SM00367; LRR_CC; 8.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Methylation; Reference proteome;
KW Repeat; Ubl conjugation pathway.
FT CHAIN 1..479
FT /note="F-box/LRR-repeat protein 16"
FT /id="PRO_0000119863"
FT DOMAIN 94..139
FT /note="F-box"
FT REPEAT 244..266
FT /note="LRR 1"
FT REPEAT 267..290
FT /note="LRR 2"
FT REPEAT 319..343
FT /note="LRR 3"
FT REPEAT 345..369
FT /note="LRR 4"
FT REPEAT 371..395
FT /note="LRR 5"
FT REPEAT 396..420
FT /note="LRR 6"
FT REPEAT 446..470
FT /note="LRR 7"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..60
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 92
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:A2RT62"
FT VAR_SEQ 1..212
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056996"
FT VARIANT 429
FT /note="L -> P (in dbSNP:rs17855603)"
FT /evidence="ECO:0000269|PubMed:11157797,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_028163"
SQ SEQUENCE 479 AA; 51658 MW; BC5E2EF407142A5A CRC64;
MSSPGIDGDP KPPCLPRNGL VKLPGQPNGL GAASITKGTP ATKNRPCQPP PPPTLPPPSL
AAPLSRAALA GGPCTPAGGP ASALAPGHPA ERPPLATDEK ILNGLFWYFS ACEKCVLAQV
CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL PGGEKEFVNL QGFAARGFEG FCLVGVSDLD
ICEFIDNYAL SKKGVKAMSL KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL
SARITSLSVS DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR
LLSCWEITNH GVVNVVHSLP NLTALSLSGC SKVTDDGVEL VAENLRKLRS LDLSWCPRIT
DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR SLYLRWCCQV QDFGLKHLLA
LGSLRLLSLA GCPLLTTTGL SGLVQLQELE ELELTNCPGA TPELFKYFSQ HLPRCLVIE
