FXL16_MOUSE
ID FXL16_MOUSE Reviewed; 479 AA.
AC A2RT62;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=F-box/LRR-repeat protein 16;
DE AltName: Full=F-box and leucine-rich repeat protein 16;
GN Name=Fbxl16;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-92, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SKP1 and CUL1. {ECO:0000250}.
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DR EMBL; BC132383; AAI32384.1; -; mRNA.
DR CCDS; CCDS50036.1; -.
DR RefSeq; NP_001157697.1; NM_001164225.1.
DR RefSeq; XP_006524083.1; XM_006524020.3.
DR AlphaFoldDB; A2RT62; -.
DR SMR; A2RT62; -.
DR BioGRID; 229576; 25.
DR STRING; 10090.ENSMUSP00000048562; -.
DR iPTMnet; A2RT62; -.
DR PhosphoSitePlus; A2RT62; -.
DR SwissPalm; A2RT62; -.
DR PaxDb; A2RT62; -.
DR PeptideAtlas; A2RT62; -.
DR PRIDE; A2RT62; -.
DR ProteomicsDB; 271654; -.
DR Antibodypedia; 22839; 129 antibodies from 26 providers.
DR DNASU; 214931; -.
DR Ensembl; ENSMUST00000045692; ENSMUSP00000048562; ENSMUSG00000025738.
DR Ensembl; ENSMUST00000236165; ENSMUSP00000157536; ENSMUSG00000025738.
DR GeneID; 214931; -.
DR KEGG; mmu:214931; -.
DR UCSC; uc008bcc.2; mouse.
DR CTD; 146330; -.
DR MGI; MGI:2448488; Fbxl16.
DR VEuPathDB; HostDB:ENSMUSG00000025738; -.
DR eggNOG; KOG1947; Eukaryota.
DR GeneTree; ENSGT00940000159138; -.
DR HOGENOM; CLU_027026_1_0_1; -.
DR InParanoid; A2RT62; -.
DR OMA; FWAGLMP; -.
DR OrthoDB; 1282076at2759; -.
DR PhylomeDB; A2RT62; -.
DR TreeFam; TF324260; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR BioGRID-ORCS; 214931; 5 hits in 72 CRISPR screens.
DR PRO; PR:A2RT62; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; A2RT62; protein.
DR Bgee; ENSMUSG00000025738; Expressed in dorsal striatum and 207 other tissues.
DR ExpressionAtlas; A2RT62; baseline and differential.
DR Genevisible; A2RT62; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13516; LRR_6; 2.
DR SMART; SM00367; LRR_CC; 7.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 1: Evidence at protein level;
KW Leucine-rich repeat; Methylation; Reference proteome; Repeat;
KW Ubl conjugation pathway.
FT CHAIN 1..479
FT /note="F-box/LRR-repeat protein 16"
FT /id="PRO_0000307721"
FT DOMAIN 94..139
FT /note="F-box"
FT REPEAT 321..342
FT /note="LRR 1"
FT REPEAT 347..369
FT /note="LRR 2"
FT REPEAT 373..394
FT /note="LRR 3"
FT REPEAT 398..419
FT /note="LRR 4"
FT REPEAT 423..444
FT /note="LRR 5"
FT REPEAT 446..470
FT /note="LRR 6"
FT REGION 1..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..60
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..91
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 92
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
SQ SEQUENCE 479 AA; 51878 MW; B14320A4B15E900B CRC64;
MSSPGIDGDP KPPCLPRNGL VKLPGQPNGL GAASITKGTP AAKNRPCQPP PPPTLPPPSL
ATPLSRVALA GGPCPPASGP ASGPVSGPPV ERPPLATDEK ILNGLFWYFS ACEKCILAQV
CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL PGGEKEFVNL QGFAARGFEG FCLVGVSDLD
ICEFIDNYSL SKKGVKAMSL KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL
SARITSLSVS DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR
LLSCWEITNH GVVNVVHSLP NLTSLSLSGC SKVTDDGVEL VAENLRKLRS LDLSWCPRIT
DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR SLYLRWCCQV QDFGLKHLLA
MRNLRLLSLA GCPLLTTTGL SGLVQLQELE ELELTNCPGA TPELFKYFSQ HLPRCLVIE
