ID   FXL16_RAT               Reviewed;         479 AA.
AC   Q5MJ12;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=F-box/LRR-repeat protein 16;
DE   AltName: Full=F-box and leucine-rich repeat protein 16;
DE   AltName: Full=Spinal cord injury and regeneration-related protein 1;
GN   Name=Fbxl16; Synonyms=Scirr1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Spinal cord;
RA   Liu T., Ma Z., Liu S.;
RT   "Analysis and functional annotation of 40 expressed sequence tags from a
RT   subtracted rat injured spinal cord library.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SKP1 and CUL1. {ECO:0000250}.
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DR   EMBL; AY823669; AAV85776.1; -; mRNA.
DR   RefSeq; NP_001009504.1; NM_001009504.1.
DR   RefSeq; XP_006246082.1; XM_006246020.3.
DR   RefSeq; XP_017452931.1; XM_017597442.1.
DR   AlphaFoldDB; Q5MJ12; -.
DR   SMR; Q5MJ12; -.
DR   BioGRID; 268840; 1.
DR   STRING; 10116.ENSRNOP00000035846; -.
DR   iPTMnet; Q5MJ12; -.
DR   PhosphoSitePlus; Q5MJ12; -.
DR   jPOST; Q5MJ12; -.
DR   PaxDb; Q5MJ12; -.
DR   PRIDE; Q5MJ12; -.
DR   Ensembl; ENSRNOT00000039777; ENSRNOP00000035846; ENSRNOG00000022248.
DR   GeneID; 494223; -.
DR   KEGG; rno:494223; -.
DR   UCSC; RGD:1309127; rat.
DR   CTD; 146330; -.
DR   RGD; 1309127; Fbxl16.
DR   eggNOG; KOG1947; Eukaryota.
DR   GeneTree; ENSGT00940000159138; -.
DR   HOGENOM; CLU_027026_1_0_1; -.
DR   InParanoid; Q5MJ12; -.
DR   OMA; FWAGLMP; -.
DR   OrthoDB; 1282076at2759; -.
DR   PhylomeDB; Q5MJ12; -.
DR   TreeFam; TF324260; -.
DR   Reactome; R-RNO-8951664; Neddylation.
DR   Reactome; R-RNO-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:Q5MJ12; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000022248; Expressed in frontal cortex and 14 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13516; LRR_6; 2.
DR   SMART; SM00367; LRR_CC; 7.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat; Methylation; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..479
FT                   /note="F-box/LRR-repeat protein 16"
FT                   /id="PRO_0000119864"
FT   DOMAIN          94..139
FT                   /note="F-box"
FT   REPEAT          244..266
FT                   /note="LRR 1"
FT   REPEAT          267..290
FT                   /note="LRR 2"
FT   REPEAT          319..343
FT                   /note="LRR 3"
FT   REPEAT          345..369
FT                   /note="LRR 4"
FT   REPEAT          371..395
FT                   /note="LRR 5"
FT   REPEAT          396..420
FT                   /note="LRR 6"
FT   REPEAT          446..470
FT                   /note="LRR 7"
FT   REGION          1..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..60
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..93
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         92
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:A2RT62"
SQ   SEQUENCE   479 AA;  51851 MW;  7694D186ECEF22F4 CRC64;
     MSSPGIDGDP KPSCLPRNGL VKLPGQPNGL GAASITKGTP AAKNRPCQPP PPPTLPPPSL
     ATPLSRVALA GGPCPPASGP ASGPVPGPPV ERPPLATDEK ILNGLFWYFS ACEKCILAQV
     CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL PGGEKEFVNL QGFAARGFEG FCLVGVSDLD
     ICEFIDNYSL SKKGVKAMSL KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL
     SARITSLSVS DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR
     LLSCWEITNH GVVNVVHSLP NLTSLSLSGC SKVTDDGVEL VAENLRKLRS LDLSWCPRIT
     DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR SLYLRWCCQV QDFGLKHLLA
     MRSLRLLSLA GCPLLTTTGL SGLVQLQELE ELELTNCPGA TPELFKYFSQ HLPRCLVIE