FXL18_HUMAN
ID FXL18_HUMAN Reviewed; 805 AA.
AC Q96ME1; Q9BR90; Q9BTC7; Q9HAK7;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 2.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=F-box/LRR-repeat protein 18;
DE AltName: Full=F-box and leucine-rich repeat protein 18;
GN Name=FBXL18; Synonyms=FBL18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 424-805 (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 476-805 (ISOFORM 4).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q96ME1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96ME1-2; Sequence=VSP_013012, VSP_013013;
CC Name=3;
CC IsoId=Q96ME1-3; Sequence=VSP_013009, VSP_013010;
CC Name=4;
CC IsoId=Q96ME1-4; Sequence=VSP_013011, VSP_013014;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB13838.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK021529; BAB13838.1; ALT_INIT; mRNA.
DR EMBL; AK057042; BAB71354.1; -; mRNA.
DR EMBL; BC004228; AAH04228.1; -; mRNA.
DR EMBL; BC006426; AAH06426.2; -; mRNA.
DR EMBL; BC024256; AAH24256.1; -; mRNA.
DR CCDS; CCDS43546.1; -. [Q96ME1-4]
DR AlphaFoldDB; Q96ME1; -.
DR BioGRID; 123080; 58.
DR IntAct; Q96ME1; 16.
DR MINT; Q96ME1; -.
DR STRING; 9606.ENSP00000371805; -.
DR iPTMnet; Q96ME1; -.
DR MetOSite; Q96ME1; -.
DR PhosphoSitePlus; Q96ME1; -.
DR BioMuta; FBXL18; -.
DR DMDM; 61213731; -.
DR EPD; Q96ME1; -.
DR jPOST; Q96ME1; -.
DR MassIVE; Q96ME1; -.
DR MaxQB; Q96ME1; -.
DR PaxDb; Q96ME1; -.
DR PeptideAtlas; Q96ME1; -.
DR PRIDE; Q96ME1; -.
DR ProteomicsDB; 77339; -. [Q96ME1-1]
DR ProteomicsDB; 77340; -. [Q96ME1-2]
DR ProteomicsDB; 77341; -. [Q96ME1-3]
DR ProteomicsDB; 77342; -. [Q96ME1-4]
DR Antibodypedia; 24615; 104 antibodies from 21 providers.
DR Ensembl; ENST00000382368.8; ENSP00000371805.3; ENSG00000155034.20. [Q96ME1-4]
DR Ensembl; ENST00000415009.5; ENSP00000415064.1; ENSG00000155034.20. [Q96ME1-2]
DR Ensembl; ENST00000453700.7; ENSP00000444797.2; ENSG00000155034.20. [Q96ME1-3]
DR MANE-Select; ENST00000382368.8; ENSP00000371805.3; NM_024963.6; NP_079239.3. [Q96ME1-4]
DR UCSC; uc003son.5; human. [Q96ME1-1]
DR GeneCards; FBXL18; -.
DR HGNC; HGNC:21874; FBXL18.
DR HPA; ENSG00000155034; Tissue enhanced (brain).
DR MIM; 609084; gene.
DR neXtProt; NX_Q96ME1; -.
DR OpenTargets; ENSG00000155034; -.
DR PharmGKB; PA134949446; -.
DR VEuPathDB; HostDB:ENSG00000155034; -.
DR eggNOG; ENOG502QVW9; Eukaryota.
DR GeneTree; ENSGT00390000015109; -.
DR HOGENOM; CLU_758549_0_0_1; -.
DR InParanoid; Q96ME1; -.
DR OMA; VLYSECR; -.
DR PhylomeDB; Q96ME1; -.
DR TreeFam; TF331865; -.
DR PathwayCommons; Q96ME1; -.
DR Reactome; R-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-HSA-8951664; Neddylation.
DR Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR SignaLink; Q96ME1; -.
DR ChiTaRS; FBXL18; human.
DR Pharos; Q96ME1; Tdark.
DR PRO; PR:Q96ME1; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q96ME1; protein.
DR Bgee; ENSG00000155034; Expressed in lateral globus pallidus and 162 other tissues.
DR ExpressionAtlas; Q96ME1; baseline and differential.
DR Genevisible; Q96ME1; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR045627; FBXL18_LRR.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF00646; F-box; 1.
DR Pfam; PF19729; FBXL18_C; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat;
KW Ubl conjugation pathway.
FT CHAIN 1..805
FT /note="F-box/LRR-repeat protein 18"
FT /id="PRO_0000119867"
FT DOMAIN 25..72
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REPEAT 77..103
FT /note="LRR 1"
FT REPEAT 104..128
FT /note="LRR 2"
FT REPEAT 129..153
FT /note="LRR 3"
FT REPEAT 177..201
FT /note="LRR 4"
FT REPEAT 324..352
FT /note="LRR 5"
FT REPEAT 367..392
FT /note="LRR 6"
FT REPEAT 393..422
FT /note="LRR 7"
FT REPEAT 468..492
FT /note="LRR 8"
FT REPEAT 516..540
FT /note="LRR 9"
FT REPEAT 542..567
FT /note="LRR 10"
FT REPEAT 572..597
FT /note="LRR 11"
FT REPEAT 599..623
FT /note="LRR 12"
FT VAR_SEQ 364..365
FT /note="RK -> CR (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_013009"
FT VAR_SEQ 366..805
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_013010"
FT VAR_SEQ 667..718
FT /note="RWGEVTGRRPQLFTELREEPSARTSRATGRRQPCLPDSGVVCCPCGRPLAVS
FT -> SFQAERPALNVVIFPLLHEGLTDVIRDVPLVHLDEITLFKSRVAEEPPNLWW (in
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_013011"
FT VAR_SEQ 667..668
FT /note="RW -> SR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_013012"
FT VAR_SEQ 669..805
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_013013"
FT VAR_SEQ 719..805
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_013014"
FT VARIANT 552
FT /note="N -> K (in dbSNP:rs33941092)"
FT /id="VAR_055800"
FT CONFLICT 555
FT /note="L -> P (in Ref. 1; BAB13838)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 805 AA; 88341 MW; 823FDC403787809C CRC64;
MASSGEDISN DDDDMHPAAA GMADGVHLLG FSDEILLHIL SHVPSTDLIL NVRRTCRKLA
ALCLDKSLIH TVLLQKDYQA SEDKVRQLVK EIGREIQQLS MAGCYWLPGS TVEHVARCRS
LVKVNLSGCH LTSLRLSKML SALQHLRSLA IDVSPGFDAS QLSSECKATL SRVRELKQTL
FTPSYGVVPC CTSLEKLLLY FEILDRTREG AILSGQLMVG QSNVPHYQNL RVFYARLAPG
YINQEVVRLY LAVLSDRTPQ NLHAFLISVP GSFAESGATK NLLDSMARNV VLDALQLPKS
WLNGSSLLQH MKFNNPFYFS FSRCTLSGGH LIQQVINGGK DLRSLASLNL SGCVHCLSPD
SLLRKAEDDI DSSILETLVA SCCNLRHLNL SAAHHHSSEG LGRHLCQLLA RLRHLRSLSL
PVCSVADSAP RADRAPAQPA MHAVPRGFGK KVRVGVQSCP SPFSGQACPQ PSSVFWSLLK
NLPFLEHLEL IGSNFSSAMP RNEPAIRNSL PPCSRAQSVG DSEVAAIGQL AFLRHLTLAQ
LPSVLTGSGL VNIGLQCQQL RSLSLANLGM MGKVVYMPAL SDMLKHCKRL RDLRLEQPYF
SANAQFFQAL SQCPSLQRLC LVSRSGTLQP DAVLAFMARC LQVVMCHLFT GESLATCKSL
QQSLLRRWGE VTGRRPQLFT ELREEPSART SRATGRRQPC LPDSGVVCCP CGRPLAVSGI
ILVGVSPSLV VKTTCVYRVL FKNLDYASIF FLVCLFETES HSVVQAGVQW RDLSSLQPLL
SGLQPQPPEQ LENELEIGFS YCFVI
