ID   FXL20_BOVIN             Reviewed;         436 AA.
AC   Q58DG6; A2VDQ1;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=F-box/LRR-repeat protein 20;
DE   AltName: Full=F-box and leucine-rich repeat protein 20;
GN   Name=FBXL20;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. Role in neural transmission
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SKP1 and CUL1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q58DG6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q58DG6-2; Sequence=VSP_030768;
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DR   EMBL; BT021631; AAX46478.1; -; mRNA.
DR   EMBL; BC133345; AAI33346.1; -; mRNA.
DR   RefSeq; NP_001030268.1; NM_001035096.1. [Q58DG6-2]
DR   AlphaFoldDB; Q58DG6; -.
DR   SMR; Q58DG6; -.
DR   STRING; 9913.ENSBTAP00000011020; -.
DR   PaxDb; Q58DG6; -.
DR   PRIDE; Q58DG6; -.
DR   Ensembl; ENSBTAT00000011020; ENSBTAP00000011020; ENSBTAG00000008371. [Q58DG6-1]
DR   Ensembl; ENSBTAT00000084210; ENSBTAP00000069592; ENSBTAG00000008371. [Q58DG6-2]
DR   GeneID; 511007; -.
DR   KEGG; bta:511007; -.
DR   CTD; 84961; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008371; -.
DR   eggNOG; KOG4341; Eukaryota.
DR   GeneTree; ENSGT00940000153845; -.
DR   HOGENOM; CLU_016072_7_1_1; -.
DR   InParanoid; Q58DG6; -.
DR   OMA; LCNRIRY; -.
DR   OrthoDB; 1046098at2759; -.
DR   TreeFam; TF313434; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000008371; Expressed in neutrophil and 110 other tissues.
DR   ExpressionAtlas; Q58DG6; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF13516; LRR_6; 4.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00367; LRR_CC; 12.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Leucine-rich repeat; Phosphoprotein;
KW   Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..436
FT                   /note="F-box/LRR-repeat protein 20"
FT                   /id="PRO_0000239140"
FT   DOMAIN          22..68
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REPEAT          74..100
FT                   /note="LRR 1"
FT   REPEAT          101..126
FT                   /note="LRR 2"
FT   REPEAT          127..152
FT                   /note="LRR 3"
FT   REPEAT          153..178
FT                   /note="LRR 4"
FT   REPEAT          179..204
FT                   /note="LRR 5"
FT   REPEAT          205..230
FT                   /note="LRR 6"
FT   REPEAT          231..256
FT                   /note="LRR 7"
FT   REPEAT          257..282
FT                   /note="LRR 8"
FT   REPEAT          283..308
FT                   /note="LRR 9"
FT   REPEAT          309..334
FT                   /note="LRR 10"
FT   REPEAT          335..363
FT                   /note="LRR 11"
FT   REPEAT          364..388
FT                   /note="LRR 12"
FT   REPEAT          389..414
FT                   /note="LRR 13"
FT   MOD_RES         417
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96IG2"
FT   MOD_RES         421
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96IG2"
FT   VAR_SEQ         1..14
FT                   /note="MRRDVNGVTKSRFE -> MAPSRDRLLHFGFKAT (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16305752"
FT                   /id="VSP_030768"
SQ   SEQUENCE   436 AA;  48423 MW;  39CD04A505C8CE3E CRC64;
     MRRDVNGVTK SRFEMFSNSD EAVINKKLPK ELLLRIFSFL DVVTLCRCAQ VSRAWNVLAL
     DGSNWQRIDL FDFQRDIEGR VVENISKRCG GFLRKLSLRG CLGVGDNALR TFAQNCRNIE
     VLNLNGCTKT TDATCTSLSK FCSKLRHLDL ASCTSITNMS LKALSEGCPL LEQLNISWCD
     QVTKDGIQAL VRGCGGLKAL FLKGCTQLED EALKYIGAHC PELVTLNLQT CLQITDEGLI
     TICRGCHKLQ SLCASGCSNI TDAILNALGQ NCPRLRILEV ARCSQLTDVG FTTLARNCHE
     LEKMDLEECV QITDSTLIQL SIHCPRLQVL SLSHCELITD DGIRHLGNGA CAHDQLEVIE
     LDNCPLITDA SLEHLKSCHS LERIELYDCQ QITRAGIKRL RTHLPNIKVH AYFAPVTPPP
     SVGGSRQRFC RCCIIL