ID   FXL20_RAT               Reviewed;         276 AA.
AC   Q9QZH7;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=F-box/LRR-repeat protein 20;
DE   AltName: Full=F-box and leucine-rich repeat protein 20;
DE   AltName: Full=F-box/LRR-repeat protein 2-like;
GN   Name=Fbxl20; Synonyms=Fbl2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH SKP1, SUBCELLULAR LOCATION,
RP   AND TISSUE SPECIFICITY.
RC   STRAIN=Buffalo; TISSUE=Liver;
RX   PubMed=10508920; DOI=10.1016/s0014-5793(99)01211-9;
RA   Ilyin G.P., Rialland M., Glaise D., Guguen-Guillouzo C.;
RT   "Identification of a novel Skp2-like mammalian protein containing F-box and
RT   leucine-rich repeats.";
RL   FEBS Lett. 459:75-79(1999).
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. Role in neural transmission
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SKP1 and CUL1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10508920}.
CC   -!- TISSUE SPECIFICITY: Widely expressed, with highest expression in
CC       skeletal muscle, heart and brain. {ECO:0000269|PubMed:10508920}.
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DR   EMBL; AF182443; AAF01221.1; -; mRNA.
DR   PIR; T52349; T52349.
DR   RefSeq; NP_071608.1; NM_022272.1.
DR   AlphaFoldDB; Q9QZH7; -.
DR   SMR; Q9QZH7; -.
DR   STRING; 10116.ENSRNOP00000060552; -.
DR   PaxDb; Q9QZH7; -.
DR   PRIDE; Q9QZH7; -.
DR   GeneID; 64039; -.
DR   KEGG; rno:64039; -.
DR   UCSC; RGD:621722; rat.
DR   CTD; 84961; -.
DR   RGD; 621722; Fbxl20.
DR   eggNOG; KOG4341; Eukaryota.
DR   HOGENOM; CLU_016072_7_1_1; -.
DR   InParanoid; Q9QZH7; -.
DR   OrthoDB; 1046098at2759; -.
DR   PhylomeDB; Q9QZH7; -.
DR   PRO; PR:Q9QZH7; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; Q9QZH7; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0098978; C:glutamatergic synapse; ISO:RGD.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0098685; C:Schaffer collateral - CA1 synapse; ISO:RGD.
DR   GO; GO:0045202; C:synapse; ISO:RGD.
DR   GO; GO:0001662; P:behavioral fear response; ISO:RGD.
DR   GO; GO:0099575; P:regulation of protein catabolic process at presynapse, modulating synaptic transmission; ISO:RGD.
DR   GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; ISO:RGD.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF13516; LRR_6; 3.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00367; LRR_CC; 7.
DR   PROSITE; PS50181; FBOX; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Leucine-rich repeat; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..276
FT                   /note="F-box/LRR-repeat protein 20"
FT                   /id="PRO_0000119872"
FT   DOMAIN          22..68
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REPEAT          74..100
FT                   /note="LRR 1"
FT   REPEAT          101..126
FT                   /note="LRR 2"
FT   REPEAT          127..152
FT                   /note="LRR 3"
FT   REPEAT          153..178
FT                   /note="LRR 4"
FT   REPEAT          179..204
FT                   /note="LRR 5"
FT   REPEAT          205..230
FT                   /note="LRR 6"
FT   REPEAT          231..256
FT                   /note="LRR 7"
FT   REPEAT          257..276
FT                   /note="LRR 8"
SQ   SEQUENCE   276 AA;  30460 MW;  982994F91A265E1E CRC64;
     MRRDVNGVTK SRFEMFSNSD EAVINKKLPK ELLLRIFSFL DVVTLCRCAQ VSRAWNVLAL
     DGSNWQRIDL FDFQRDIEGR VVENISKRCG GFLRKLSLRG CLGVGDNALR TFAQNCRNIE
     VLSLNGCTKT TDATCTSLSK FCSKLRHLDL ASCTSITNMS LKALSEGCPL LEQLNISWCD
     QVTKDGIQAL VRGCGGLKAL FLKGCTQLED EALKYIGAHC PELVTLNLQT CLQITDEGLI
     TICRGCHKLQ SLCASGCSNI TDAILNALGQ NCPRLR