ID   FXL21_BOVIN             Reviewed;         434 AA.
AC   Q3ZBA7;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=F-box/LRR-repeat protein 21;
DE   AltName: Full=F-box and leucine-rich repeat protein 21;
GN   Name=FBXL21;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of the SCF(FBXL21) E3
CC       ubiquitin ligase complex involved in circadian rhythm function. Plays a
CC       key role in the maintenance of both the speed and the robustness of the
CC       circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the
CC       cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2),
CC       leading to CRY proteins stabilization. The SCF(FBXL21) complex
CC       counteracts the activity of the SCF(FBXL3) complex and protects CRY
CC       proteins from degradation. Involved in the hypothalamic suprachiasmatic
CC       nucleus (SCN) clock regulating temporal organization of the daily
CC       activities (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase
CC       complex SCF(FBXL21) composed of CUL1, SKP1, RBX1 and FBXL21. Interacts
CC       with CRY1 and CRY2 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Note=Mainly localizes in the cytosol. Present at low
CC       level in the nucleus (By similarity). {ECO:0000250}.
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DR   EMBL; BC103468; AAI03469.1; -; mRNA.
DR   RefSeq; NP_001029424.1; NM_001034252.1.
DR   AlphaFoldDB; Q3ZBA7; -.
DR   SMR; Q3ZBA7; -.
DR   STRING; 9913.ENSBTAP00000003178; -.
DR   PaxDb; Q3ZBA7; -.
DR   PRIDE; Q3ZBA7; -.
DR   GeneID; 505624; -.
DR   KEGG; bta:505624; -.
DR   CTD; 213311; -.
DR   eggNOG; KOG1947; Eukaryota.
DR   HOGENOM; CLU_033637_0_0_1; -.
DR   InParanoid; Q3ZBA7; -.
DR   OrthoDB; 1027299at2759; -.
DR   TreeFam; TF352583; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0043153; P:entrainment of circadian clock by photoperiod; ISS:UniProtKB.
DR   GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF12937; F-box-like; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00367; LRR_CC; 2.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Biological rhythms; Cytoplasm; Leucine-rich repeat; Nucleus;
KW   Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..434
FT                   /note="F-box/LRR-repeat protein 21"
FT                   /id="PRO_0000282866"
FT   DOMAIN          39..85
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REPEAT          187..213
FT                   /note="LRR 1"
FT   REPEAT          214..239
FT                   /note="LRR 2"
FT   REPEAT          242..265
FT                   /note="LRR 3"
FT   REPEAT          322..347
FT                   /note="LRR 4"
FT   REPEAT          349..374
FT                   /note="LRR 5"
FT   REPEAT          375..400
FT                   /note="LRR 6"
SQ   SEQUENCE   434 AA;  48995 MW;  45DFC02CB253FF0E CRC64;
     MKRNRLSFMN KVLQSSPAVK QPKLGCHSSL SQTHMRAALL DWGNLPHHVV LRIFQYLPLI
     DRARASSVCR RWNEVFHIPD LWRKFEFELN QSAASYFNST HPDLIQQIIK KHAAHLQYVS
     FKVDSSTESA EAACGILSQL VNCSIQTLGL ISTAKPSFLN MSKSHFVSAL TVLFVNSISL
     SSIKIEDTPV DDPSLSILVA NNSGTLRRLK MSSCPHVSSN GILCVADHCQ GLRELALNYY
     MLSDKLLLAL SNETHVNLEH LRIDVMSENA GQIEFHSIKR QSWDALIKHS PGVNVVMYFF
     LYEEEMETFF KEETPVTHLY FGRSVSKEIL GRLGLNCPRL TELVVCANGI QVIDTELICI
     AEHCKNLTAL GLSECEVSCS AFIEFVRLCG RKLTHLSIME EVLIPDDVYS LGEIHTEVSK
     YLGRIWFPDV MPLW