ID   FXL22_BOVIN             Reviewed;         226 AA.
AC   Q2HJF2;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=F-box and leucine-rich protein 22;
GN   Name=FBXL22;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of
CC       sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC) (By
CC       similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line
CC       {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC105485; AAI05486.1; -; mRNA.
DR   RefSeq; NP_001039621.1; NM_001046156.2.
DR   AlphaFoldDB; Q2HJF2; -.
DR   SMR; Q2HJF2; -.
DR   STRING; 9913.ENSBTAP00000011600; -.
DR   PaxDb; Q2HJF2; -.
DR   PRIDE; Q2HJF2; -.
DR   GeneID; 513821; -.
DR   KEGG; bta:513821; -.
DR   CTD; 283807; -.
DR   eggNOG; KOG1947; Eukaryota.
DR   HOGENOM; CLU_1239778_0_0_1; -.
DR   InParanoid; Q2HJF2; -.
DR   OrthoDB; 1332077at2759; -.
DR   TreeFam; TF332457; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR   GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IBA:GO_Central.
DR   GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   SMART; SM00367; LRR_CC; 3.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Leucine-rich repeat; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..226
FT                   /note="F-box and leucine-rich protein 22"
FT                   /id="PRO_0000247148"
FT   DOMAIN          1..46
FT                   /note="F-box"
FT   REPEAT          15..40
FT                   /note="LRR 1"
FT   REPEAT          43..72
FT                   /note="LRR 2"
FT   REPEAT          95..123
FT                   /note="LRR 3"
FT   REPEAT          124..149
FT                   /note="LRR 4"
FT   REPEAT          150..175
FT                   /note="LRR 5"
FT   REPEAT          176..201
FT                   /note="LRR 6"
SQ   SEQUENCE   226 AA;  25507 MW;  84813989C3684A36 CRC64;
     MHITQLNREC LLHLFSFLDK DSRKNLARTC PQLQDVFEDP ALWPLLHFRS LTELKKDNFL
     LSPALRSLSI CWHSSRVQVC SIEDWLKSAL QRNICSRHES LVNDFLLQVC DRCPNLASVT
     LSGCGHVTDD CLARLLRCCP RLRALHLENC ARVTNRTLTA VAAHGRALQT LHVDFCRNVS
     AAGLRRLRAA CPRLTLRAEH SAAMIPDQLP RGPHAPGAAL RKLLLR