FXL22_MOUSE
ID FXL22_MOUSE Reviewed; 236 AA.
AC Q8C7B6; Q8C3G3; Q8C3V6;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=F-box and leucine-rich protein 22;
GN Name=Fbxl22;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Jaw, and Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=22972877; DOI=10.1161/circresaha.112.271007;
RA Spaich S., Will R.D., Just S., Spaich S., Kuhn C., Frank D., Berger I.M.,
RA Wiemann S., Korn B., Koegl M., Backs J., Katus H.A., Rottbauer W., Frey N.;
RT "F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box
RT protein that regulates sarcomeric protein turnover and is essential for
RT maintenance of contractile function in vivo.";
RL Circ. Res. 111:1504-1516(2012).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of
CC sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC) (By
CC similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line
CC {ECO:0000269|PubMed:22972877}.
CC -!- TISSUE SPECIFICITY: Enriched in cardiac muscle (at protein level).
CC {ECO:0000269|PubMed:22972877}.
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DR EMBL; AK052175; BAC34870.1; -; mRNA.
DR EMBL; AK084845; BAC39291.1; -; mRNA.
DR EMBL; AK085980; BAC39583.1; -; mRNA.
DR EMBL; BC100535; AAI00536.1; -; mRNA.
DR CCDS; CCDS23304.1; -.
DR RefSeq; NP_780415.1; NM_175206.4.
DR AlphaFoldDB; Q8C7B6; -.
DR SMR; Q8C7B6; -.
DR STRING; 10090.ENSMUSP00000060137; -.
DR PaxDb; Q8C7B6; -.
DR PRIDE; Q8C7B6; -.
DR ProteomicsDB; 267539; -.
DR Antibodypedia; 25713; 64 antibodies from 13 providers.
DR DNASU; 74165; -.
DR Ensembl; ENSMUST00000056890; ENSMUSP00000060137; ENSMUSG00000050503.
DR GeneID; 74165; -.
DR KEGG; mmu:74165; -.
DR UCSC; uc009qex.2; mouse.
DR CTD; 283807; -.
DR MGI; MGI:1921415; Fbxl22.
DR VEuPathDB; HostDB:ENSMUSG00000050503; -.
DR eggNOG; KOG1947; Eukaryota.
DR GeneTree; ENSGT00390000003748; -.
DR HOGENOM; CLU_1239778_0_0_1; -.
DR InParanoid; Q8C7B6; -.
DR OMA; RVDFCRN; -.
DR OrthoDB; 1332077at2759; -.
DR PhylomeDB; Q8C7B6; -.
DR TreeFam; TF332457; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 74165; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Fbxl22; mouse.
DR PRO; PR:Q8C7B6; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8C7B6; protein.
DR Bgee; ENSMUSG00000050503; Expressed in urinary bladder and 85 other tissues.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; ISO:MGI.
DR GO; GO:0030018; C:Z disc; ISO:MGI.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; ISO:MGI.
DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IBA:GO_Central.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISO:MGI.
DR GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR SMART; SM00367; LRR_CC; 3.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Leucine-rich repeat; Reference proteome; Repeat;
KW Ubl conjugation pathway.
FT CHAIN 1..236
FT /note="F-box and leucine-rich protein 22"
FT /id="PRO_0000247150"
FT DOMAIN 1..46
FT /note="F-box"
FT REPEAT 15..40
FT /note="LRR 1"
FT REPEAT 43..72
FT /note="LRR 2"
FT REPEAT 98..123
FT /note="LRR 3"
FT REPEAT 124..149
FT /note="LRR 4"
FT REPEAT 150..175
FT /note="LRR 5"
FT REPEAT 176..201
FT /note="LRR 6"
SQ SEQUENCE 236 AA; 26320 MW; 1AC2A66D54A53B81 CRC64;
MHITQLNREC LLCLFSFLDK DSRRSLSRTC SQLRDVFEDP TLWPLLHFHS LAELKKDNFR
LSPALRSLSI CWHSSRVQVC SIEDWLKSAL QRSICSQHES LVNDFLLQVC NRCPNLTSVT
LSGCGHVTDD CLARLLLSCP RLRTLRLENC ARVTNRTLAA VAAHGRALQT LHVDFCRNVS
AAGLLRLRAA CPNLRLSAER SAAMIPDQPP RARVCAASAF SAAPGRQSMP HPTGSY
