ID   FXO3B_HUMAN             Reviewed;         290 AA.
AC   A0A2Z4LIS9;
DT   05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2018, sequence version 1.
DT   03-AUG-2022, entry version 20.
DE   RecName: Full=Forkhead box protein O3B {ECO:0000305};
GN   Name=FOXO3B {ECO:0000312|HGNC:HGNC:3822};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND PHOSPHORYLATION AT
RP   THR-117.
RX   PubMed=29925039; DOI=10.1016/j.gene.2018.06.048;
RA   Santo E.E., Paik J.;
RT   "A splice junction-targeted CRISPR approach (spJCRISPR) reveals human
RT   FOXO3B to be a protein-coding gene.";
RL   Gene 673:95-101(2018).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
CC   -!- FUNCTION: Transcription factor. {ECO:0000250|UniProtKB:Q9R1E0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:29925039}.
CC       Note=Does not translocate to the nucleus upon phosphorylation.
CC       {ECO:0000269|PubMed:29925039}.
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DR   EMBL; AC026271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; MG753997; AWX41297.1; -; mRNA.
DR   AlphaFoldDB; A0A2Z4LIS9; -.
DR   SMR; A0A2Z4LIS9; -.
DR   iPTMnet; A0A2Z4LIS9; -.
DR   jPOST; A0A2Z4LIS9; -.
DR   MassIVE; A0A2Z4LIS9; -.
DR   PeptideAtlas; A0A2Z4LIS9; -.
DR   Ensembl; ENST00000395675.7; ENSP00000499455.1; ENSG00000240445.6.
DR   MANE-Select; ENST00000395675.7; ENSP00000499455.1; NM_001368135.1; NP_001355064.1.
DR   GeneCards; FOXO3B; -.
DR   HGNC; HGNC:3822; FOXO3B.
DR   HPA; ENSG00000240445; Low tissue specificity.
DR   neXtProt; NX_A0A2Z4LIS9; -.
DR   OpenTargets; ENSG00000240445; -.
DR   VEuPathDB; HostDB:ENSG00000240445; -.
DR   GeneTree; ENSGT00940000159826; -.
DR   OMA; PAQCETR; -.
DR   PRO; PR:A0A2Z4LIS9; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000240445; Expressed in ganglionic eminence and 110 other tissues.
DR   ExpressionAtlas; A0A2Z4LIS9; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..290
FT                   /note="Forkhead box protein O3B"
FT                   /id="PRO_0000447437"
FT   DNA_BIND        242..290
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          44..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..154
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         117
FT                   /note="Phosphothreonine; by PKB/AKT1"
FT                   /evidence="ECO:0000269|PubMed:29925039"
SQ   SEQUENCE   290 AA;  29900 MW;  0331CB5A1FE8A6E7 CRC64;
     METDLAEMPE KGVLSSQDSP HFQEKSTEEG EVAALRLTAR SQAAAAAAAP GSRSLRGVHV
     PPPLHPAPAR EESARTPAAA GRAAKMAEAP ASPAPLSPLE VELDPEFEPQ SRPRSCTWPL
     QRPELQASPA KPSGETAADS MIPEEEDDED DEDGGGRAGS AMAIGGGGGS RTLVSGLLLE
     DSVRVLAPGG QDPGSGPATA AGGLSGGTQA LLQPQQPLPP PQPGAAGGSG QPRKCSSRRN
     AWGNLSYADL ITRAIESSPD RRLTLSQIYE WMVSCVPYFK DKGNSNSSAG