ID   FXRD1_BOVIN             Reviewed;         486 AA.
AC   Q5EA45; Q58CP5; Q5EAA3;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=FAD-dependent oxidoreductase domain-containing protein 1;
DE            EC=1.-.-.-;
GN   Name=FOXRED1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the assembly of the mitochondrial membrane
CC       respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late
CC       stages of complex I assembly. {ECO:0000250|UniProtKB:Q96CU9}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SUBUNIT: Associates with components of the mitochondrial respiratory
CC       chain complex I. {ECO:0000250|UniProtKB:Q96CU9}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q96CU9}; Single-pass membrane protein
CC       {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5EA45-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5EA45-2; Sequence=VSP_022627, VSP_022628;
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DR   EMBL; BT020666; AAX08683.1; -; mRNA.
DR   EMBL; BT020724; AAX08741.1; -; mRNA.
DR   EMBL; BT021902; AAX46749.1; -; mRNA.
DR   EMBL; BC120036; AAI20037.1; -; mRNA.
DR   RefSeq; NP_001029543.2; NM_001034371.3. [Q5EA45-1]
DR   AlphaFoldDB; Q5EA45; -.
DR   SMR; Q5EA45; -.
DR   STRING; 9913.ENSBTAP00000030261; -.
DR   PaxDb; Q5EA45; -.
DR   GeneID; 510097; -.
DR   KEGG; bta:510097; -.
DR   CTD; 55572; -.
DR   eggNOG; KOG2853; Eukaryota.
DR   HOGENOM; CLU_007884_4_4_1; -.
DR   InParanoid; Q5EA45; -.
DR   OrthoDB; 752680at2759; -.
DR   TreeFam; TF314003; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   Pfam; PF01266; DAO; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Electron transport; FAD; Flavoprotein; Membrane;
KW   Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW   Reference proteome; Respiratory chain; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..486
FT                   /note="FAD-dependent oxidoreductase domain-containing
FT                   protein 1"
FT                   /id="PRO_0000274141"
FT   TRANSMEM        66..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         368..375
FT                   /note="EEEPDPGN -> PLPTKGTN (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16305752"
FT                   /id="VSP_022627"
FT   VAR_SEQ         376..486
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16305752"
FT                   /id="VSP_022628"
FT   CONFLICT        345
FT                   /note="P -> S (in Ref. 1; AAX08683)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        360
FT                   /note="V -> L (in Ref. 1; AAX08683)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   486 AA;  54082 MW;  A3468B7096D61654 CRC64;
     MLRRALRLRL GPCLSGRGLG TYRRGSTLDW DGKVSEIKKK IQSIFPGGAW NPLYDTSHLP
     PERSDVVIVG GGVLGLSVAY WLKRLEKQQG AIRVLVVERD HTYARASTVL SVGGIRQQFS
     LPQNVQLSLF SAEFLRNINE YLAVVDDPPL DLQFNPSGYL LLASEEGAAI MERNVKMQRQ
     EGAKVCLMSP EQLQKKFPWI NTEGVALASY GLENEGWFDP WCLLQGLRRK LQSMGVLFCQ
     GEVTRFISSS SHMETASGEQ LTLKRIHEVH VKMDHSQEFQ PVECAIVVNA AGAWSGQIAE
     LAGVGNGPPG TMQGTKLPVE PRKRYVYLWH CPQGPGLEAP LVADPSGAYF RREGLGNNYV
     GSCSPTEEEE PDPGNLEVDY DFFQEKVWPR LAQRVPAFET LKVRSAWAGY YDYNTFDQNG
     VVGPHPLVVN MYFATGFSGH GLQQAPAVGR AVAEMVLEGH FQTINLSPFL FSRFYFGEKA
     QEHCIL