FXRD1_MACFA
ID FXRD1_MACFA Reviewed; 486 AA.
AC Q4R510;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=FAD-dependent oxidoreductase domain-containing protein 1;
DE EC=1.-.-.-;
GN Name=FOXRED1; ORFNames=QflA-14174;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Frontal cortex;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the assembly of the mitochondrial membrane
CC respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late
CC stages of complex I assembly. {ECO:0000250|UniProtKB:Q96CU9}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- SUBUNIT: Associates with components of the mitochondrial respiratory
CC chain complex I. {ECO:0000250|UniProtKB:Q96CU9}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q96CU9}; Single-pass membrane protein
CC {ECO:0000255}.
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DR EMBL; AB169734; BAE01815.1; -; mRNA.
DR RefSeq; XP_005580173.2; XM_005580116.2.
DR AlphaFoldDB; Q4R510; -.
DR SMR; Q4R510; -.
DR STRING; 9541.XP_005580173.1; -.
DR GeneID; 101925787; -.
DR KEGG; mcf:101925787; -.
DR CTD; 55572; -.
DR VEuPathDB; HostDB:ENSMFAG00000031974; -.
DR eggNOG; KOG2853; Eukaryota.
DR OrthoDB; 752680at2759; -.
DR Proteomes; UP000233100; Chromosome 14.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR Gene3D; 3.50.50.60; -; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR Pfam; PF01266; DAO; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
PE 2: Evidence at transcript level;
KW Electron transport; FAD; Flavoprotein; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Oxidoreductase; Reference proteome;
KW Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..486
FT /note="FAD-dependent oxidoreductase domain-containing
FT protein 1"
FT /id="PRO_0000274143"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 486 AA; 53700 MW; 88E90D6441E8D1AC CRC64;
MIRRVLPHGL GRGLLTRRPG TRRGGFSLDW DGKVSEIKKK IKSILPGTPC DVLPDTSHLP
PEHSDVVVVG GGVLGLSVAY WLKQLENRRG GMRVLVVERD HTYSQASTGL SVGGICQQFS
LPENIQLSLF SASFLRNINE YLAVTNAPPL DLQFNPSGYL LLASEKDAAA MESNVKVQKQ
EGAKVCLMSP DQLRNKFPWI NTEGVALASY GMENEGWFDP WCLLHGLRQK LMSMGVFFCQ
GEVTRFVTSS QRMMTTDDEM VTLKSIHEVH VKMDHSLEYQ PVECAIVINA AGAWSAQIAA
LAGIGKGPPG TLQGTKLPVE PRKRYVYVWH CPQGPGLETP LVADTSGAYF RREGLGSNYL
GGRSPAEEEE PDPANLEVDH DFFQEKVWPH LALRVPAFET LKVQTAWAGY YDYNTFDQNG
VVGPHPLVVN MYFATGFSGH GLQQAPGVGR AVAEMILEGS FQTIDLSPFL FNRFYLGEKT
QENNIM