ID   FXRD1_XENLA             Reviewed;         499 AA.
AC   Q6DCP1;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=FAD-dependent oxidoreductase domain-containing protein 1;
DE            EC=1.-.-.-;
GN   Name=foxred1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the assembly of the mitochondrial membrane
CC       respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late
CC       stages of complex I assembly. {ECO:0000250|UniProtKB:Q96CU9}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q96CU9}; Single-pass membrane protein
CC       {ECO:0000255}.
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DR   EMBL; BC077963; AAH77963.1; -; mRNA.
DR   RefSeq; NP_001087061.1; NM_001093592.1.
DR   AlphaFoldDB; Q6DCP1; -.
DR   SMR; Q6DCP1; -.
DR   DNASU; 446896; -.
DR   GeneID; 446896; -.
DR   KEGG; xla:446896; -.
DR   CTD; 446896; -.
DR   Xenbase; XB-GENE-5896625; foxred1.L.
DR   OrthoDB; 752680at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 446896; Expressed in kidney and 20 other tissues.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   Pfam; PF01266; DAO; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   2: Evidence at transcript level;
KW   Electron transport; FAD; Flavoprotein; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Oxidoreductase; Reference proteome;
KW   Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..499
FT                   /note="FAD-dependent oxidoreductase domain-containing
FT                   protein 1"
FT                   /id="PRO_0000274145"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   499 AA;  55597 MW;  555D56046A936403 CRC64;
     MYVSSLKFPF LGIGVWKGVR LWRQRSLGTS ACALKQDDFI KELDQNFVRL QKKLMDSLPS
     SDWSPFTPTG DLPPERADVV IVGGGVMGWS IAYWLKQKEN RRGALKVVVV ERDPTYSRAS
     TVLSAGGIRQ QFSRPENIQM SLFSAQFLRN INEHLGVVNE DRIDIQFNPS GYLFLASEEG
     ATIMEENYNV QRECGAQVTL MLPDQLKKKF PWINTNGVAL ASYGLENEGW FDPWTLLNAF
     RRKALSMGVY QCHGEVTDFS TAKREMITAD GDPVTFSRIG HVTVQMPNSL ESQSVECSLV
     INAAGAWSSK VAELAGIGTG PSNSLEGIKL PVEPKKRYVY VVHCPNGPGL DCPLLIDNSG
     AYFRREGLGG NYIAGKSPAE EEEPDISNME VDHDFFQEKV WPLLAHRVPA FESLKVKTSW
     AGYYDYNTYD QNGVVGMHPL VNNLFFATGF SGHGLQHSPA VGRAVAELIV DGGFKTLNLS
     SFSFRRFWSQ EPLLERNIV