FXRD2_MOUSE
ID FXRD2_MOUSE Reviewed; 665 AA.
AC Q3USW5; Q3TCC4; Q5RJH0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=FAD-dependent oxidoreductase domain-containing protein 2;
DE Flags: Precursor;
GN Name=Foxred2 {ECO:0000312|MGI:MGI:106315}; Synonyms=D15Bwg0759e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable flavoprotein which may function in endoplasmic
CC reticulum associated degradation (ERAD). May bind non-native proteins
CC in the endoplasmic reticulum and target them to the ubiquitination
CC machinery for subsequent degradation (By similarity). {ECO:0000250}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- SUBUNIT: Interacts with SEL1L. May interact with OS9 and DNAJC10.
CC Interacts with TXNDC16. {ECO:0000250|UniProtKB:Q8IWF2}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-
CC ProRule:PRU10138}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FOXRED2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE42033.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK140027; BAE24215.1; -; mRNA.
DR EMBL; AK170795; BAE42033.1; ALT_FRAME; mRNA.
DR EMBL; AL589650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC086662; AAH86662.1; -; mRNA.
DR CCDS; CCDS27607.1; -.
DR RefSeq; NP_001017983.2; NM_001017983.2.
DR RefSeq; NP_001161732.1; NM_001168260.1.
DR AlphaFoldDB; Q3USW5; -.
DR SMR; Q3USW5; -.
DR BioGRID; 232097; 2.
DR STRING; 10090.ENSMUSP00000016696; -.
DR GlyGen; Q3USW5; 1 site.
DR PhosphoSitePlus; Q3USW5; -.
DR EPD; Q3USW5; -.
DR MaxQB; Q3USW5; -.
DR PaxDb; Q3USW5; -.
DR PeptideAtlas; Q3USW5; -.
DR PRIDE; Q3USW5; -.
DR ProteomicsDB; 273394; -.
DR Antibodypedia; 25683; 98 antibodies from 22 providers.
DR DNASU; 239554; -.
DR Ensembl; ENSMUST00000016696; ENSMUSP00000016696; ENSMUSG00000016552.
DR Ensembl; ENSMUST00000117725; ENSMUSP00000113403; ENSMUSG00000016552.
DR GeneID; 239554; -.
DR KEGG; mmu:239554; -.
DR UCSC; uc007woj.2; mouse.
DR CTD; 80020; -.
DR MGI; MGI:106315; Foxred2.
DR VEuPathDB; HostDB:ENSMUSG00000016552; -.
DR eggNOG; KOG1399; Eukaryota.
DR GeneTree; ENSGT00640000091519; -.
DR HOGENOM; CLU_014290_1_0_1; -.
DR InParanoid; Q3USW5; -.
DR OMA; FIHMVSR; -.
DR OrthoDB; 461621at2759; -.
DR PhylomeDB; Q3USW5; -.
DR TreeFam; TF324712; -.
DR BioGRID-ORCS; 239554; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Foxred2; mouse.
DR PRO; PR:Q3USW5; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q3USW5; protein.
DR Bgee; ENSMUSG00000016552; Expressed in secondary oocyte and 198 other tissues.
DR Genevisible; Q3USW5; MM.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; ISS:UniProtKB.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; ISS:UniProtKB.
DR GO; GO:0004497; F:monooxygenase activity; IBA:GO_Central.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; ISS:UniProtKB.
DR Gene3D; 3.50.50.60; -; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR SUPFAM; SSF51905; SSF51905; 1.
DR PROSITE; PS00014; ER_TARGET; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; FAD; Flavoprotein; Glycoprotein; Oxidoreductase;
KW Reference proteome; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..665
FT /note="FAD-dependent oxidoreductase domain-containing
FT protein 2"
FT /id="PRO_0000337693"
FT REGION 642..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 662..665
FT /note="Prevents secretion from ER"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10138"
FT COMPBIAS 642..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 136
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 298
FT /note="N -> S (in Ref. 1; BAE42033)"
FT /evidence="ECO:0000305"
FT CONFLICT 329
FT /note="L -> P (in Ref. 3; AAH86662)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 665 AA; 76004 MW; 077E8266EB031C24 CRC64;
MGPSGLLVAL ALHLAVCSRP HRDYCVLGAG PAGLQMAAFL HRAGRDYEVF ERESAPGSFF
TRYPRHRKLI SINKRHTGKA NAEFNLRHDW NSLLSDDPHL LFRHYSQAYF PDASDMVRYL
GDFARRLGLH VLYNTNITHV TLDKDPQAWN GHYFILTDQK GQVYQCSVLL VATGLAVPKL
VDFPGSEYVE GYESVSVDPE DFVGQNVLIL GHGNSAFETA ENILGVTNFV HMLSRSRVRL
SWATHYVGDV RAINNGLLDT YQLKSLDGLL ESDLEYLALV KDSKGKFHVT LKFLLENNSS
QSADSIPLPE DDNDNFAMRV AYDRVIRCLG WTFDFSIFDQ SLRLSSGTEF SKKYPLIKAS
YESKGSRGLF ILGTASHSVD YRKSAGGFIH GFRYTVRAVH RLLEHRHHGI PWPSTEYPIT
QLTSSIIRRV NEASGLYQMF SVLADIILLK ENATAFEYLE EFPMQMLAQL EMLTGRTARH
GLFVINMEYG KNFSGPEKDV FYYDRSVAHI EDAWMSNFLH PVIYYYRHLP TEQDMRFRPA
QWPLPRPTAI HHIVEDFLTD WTAPVGHILP LRRFLENCLD TDLRSFYAES CFLFTLTRQR
LPPFCQQGYL RMQGLSSTKS LWQHGVESRL LQDYTAMENS NRWLGDHSTA PEPLTQSLDS
NKEEL
