FXY11_DANRE
ID FXY11_DANRE Reviewed; 69 AA.
AC C0HJJ0;
DT 11-JUN-2014, integrated into UniProtKB/Swiss-Prot.
DT 11-JUN-2014, sequence version 1.
DT 03-AUG-2022, entry version 37.
DE RecName: Full=FXYD domain-containing ion transport regulator 11 {ECO:0000303|PubMed:21423371};
DE Flags: Precursor;
GN Name=fxyd11 {ECO:0000303|PubMed:21423371};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR
RP LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=21423371; DOI=10.3389/fphys.2010.00129;
RA Saito K., Nakamura N., Ito Y., Hoshijima K., Esaki M., Zhao B., Hirose S.;
RT "Identification of zebrafish Fxyd11a protein that is highly expressed in
RT ion-transporting epithelium of the gill and skin and its possible role in
RT ion homeostasis.";
RL Front. Physiol. 1:129-129(2010).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000269|PubMed:23594743};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: May modulate the activity of a sodium/potassium-transporting
CC ATPase. {ECO:0000303|PubMed:21423371}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21423371};
CC Single-pass type I membrane protein {ECO:0000269|PubMed:21423371}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:21423371}; Synonyms=a
CC {ECO:0000303|PubMed:21423371}, zFxyd11a {ECO:0000303|PubMed:21423371};
CC IsoId=C0HJJ0-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:21423371}; Synonyms=b
CC {ECO:0000303|PubMed:21423371}, zFxyd11b {ECO:0000303|PubMed:21423371};
CC IsoId=C0HJJ0-2; Sequence=VSP_054936;
CC -!- TISSUE SPECIFICITY: Detected in adult gill and in larval skin at 2 days
CC post-fertilization (at protein level). In adult gill, strong expression
CC is found in the basal regions of the secondary lamellae.
CC {ECO:0000269|PubMed:21423371}.
CC -!- DEVELOPMENTAL STAGE: Expressed from 1 day post-fertilization.
CC {ECO:0000269|PubMed:21423371}.
CC -!- INDUCTION: Induced in larvae and adult gills by low salinity and
CC repressed by high salinity. {ECO:0000269|PubMed:21423371}.
CC -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein results in an
CC increased number of sodium/potassium-transporting ATPase-expressing
CC cells in larval skin. {ECO:0000269|PubMed:21423371}.
CC -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000255}.
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DR EMBL; FP016247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001268947.1; NM_001282018.1. [C0HJJ0-1]
DR RefSeq; NP_001268949.1; NM_001282020.1. [C0HJJ0-2]
DR AlphaFoldDB; C0HJJ0; -.
DR SMR; C0HJJ0; -.
DR Ensembl; ENSDART00000164436; ENSDARP00000137233; ENSDARG00000099117. [C0HJJ0-1]
DR GeneID; 569335; -.
DR KEGG; dre:569335; -.
DR CTD; 569335; -.
DR ZFIN; ZDB-GENE-030131-33; fxyd11.
DR GeneTree; ENSGT00940000177055; -.
DR OMA; NQCARVA; -.
DR PRO; PR:C0HJJ0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 16.
DR Bgee; ENSDARG00000099117; Expressed in pharyngeal gill and 11 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0043269; P:regulation of ion transport; IEA:InterPro.
DR InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..69
FT /note="FXYD domain-containing ion transport regulator 11"
FT /evidence="ECO:0000255"
FT /id="PRO_0000429377"
FT TOPO_DOM 23..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 62..69
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:21423371"
FT /id="VSP_054936"
SQ SEQUENCE 69 AA; 7604 MW; 1FD490EE8D12851E CRC64;
MSQLTELVLL TVFLALFSRA EANPFVYNYE ALRIGGLVFT CVLVAGAVTA LCWGQCKPKR
KHDDDASKI
