FXYD4_MOUSE
ID FXYD4_MOUSE Reviewed; 88 AA.
AC Q9D2W0;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=FXYD domain-containing ion transport regulator 4;
DE AltName: Full=Channel-inducing factor;
DE Short=CHIF;
DE Flags: Precursor;
GN Name=Fxyd4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RA Garty H.;
RT "Genomic sequence of mouse CHIF (FXYD4).";
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000305}.
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DR EMBL; AF362729; AAK51508.1; -; Genomic_DNA.
DR EMBL; AK018728; BAB31372.1; -; mRNA.
DR EMBL; BC086918; AAH86918.1; -; mRNA.
DR CCDS; CCDS20468.1; -.
DR RefSeq; NP_001166843.1; NM_001173372.1.
DR RefSeq; NP_387468.1; NM_033648.1.
DR RefSeq; XP_006505358.1; XM_006505295.3.
DR AlphaFoldDB; Q9D2W0; -.
DR SMR; Q9D2W0; -.
DR BioGRID; 223770; 1.
DR STRING; 10090.ENSMUSP00000005114; -.
DR iPTMnet; Q9D2W0; -.
DR PhosphoSitePlus; Q9D2W0; -.
DR PaxDb; Q9D2W0; -.
DR PRIDE; Q9D2W0; -.
DR ProteomicsDB; 266893; -.
DR Antibodypedia; 2752; 25 antibodies from 15 providers.
DR DNASU; 108017; -.
DR Ensembl; ENSMUST00000005114; ENSMUSP00000005114; ENSMUSG00000004988.
DR Ensembl; ENSMUST00000203082; ENSMUSP00000144700; ENSMUSG00000004988.
DR Ensembl; ENSMUST00000204214; ENSMUSP00000145302; ENSMUSG00000004988.
DR GeneID; 108017; -.
DR KEGG; mmu:108017; -.
DR UCSC; uc009dlh.1; mouse.
DR CTD; 53828; -.
DR MGI; MGI:1889005; Fxyd4.
DR VEuPathDB; HostDB:ENSMUSG00000004988; -.
DR eggNOG; ENOG502TDGY; Eukaryota.
DR GeneTree; ENSGT00940000153062; -.
DR HOGENOM; CLU_171208_0_1_1; -.
DR InParanoid; Q9D2W0; -.
DR OMA; QLGGMIC; -.
DR OrthoDB; 1606794at2759; -.
DR PhylomeDB; Q9D2W0; -.
DR TreeFam; TF333443; -.
DR Reactome; R-MMU-5578775; Ion homeostasis.
DR Reactome; R-MMU-936837; Ion transport by P-type ATPases.
DR BioGRID-ORCS; 108017; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Fxyd4; mouse.
DR PRO; PR:Q9D2W0; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9D2W0; protein.
DR Bgee; ENSMUSG00000004988; Expressed in right kidney and 75 other tissues.
DR ExpressionAtlas; Q9D2W0; baseline and differential.
DR Genevisible; Q9D2W0; MM.
DR GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; ISO:MGI.
DR GO; GO:0051117; F:ATPase binding; IPI:MGI.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR GO; GO:0005267; F:potassium channel activity; ISO:MGI.
DR GO; GO:0098662; P:inorganic cation transmembrane transport; ISO:MGI.
DR GO; GO:0043269; P:regulation of ion transport; IEA:InterPro.
DR InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR PROSITE; PS01310; FXYD; 1.
PE 3: Inferred from homology;
KW Ion channel; Ion transport; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..88
FT /note="FXYD domain-containing ion transport regulator 4"
FT /id="PRO_0000010367"
FT TOPO_DOM 21..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..88
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 88 AA; 9269 MW; 7EB0140941CFE926 CRC64;
MEEITCAFLL LLAGLPALEA SDPVDKDSPF YYDWESLQLG GLIFGGLLCI AGIAMALSGK
CKCRRTHKPS SLPGKATPLI IPGSANTC
