FXYD5_RAT
ID FXYD5_RAT Reviewed; 178 AA.
AC P59647; Q6P9W0;
DT 30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=FXYD domain-containing ion transport regulator 5;
DE Flags: Precursor;
GN Name=Fxyd5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION.
RX PubMed=10950925; DOI=10.1006/geno.2000.6274;
RA Sweadner K.J., Rael E.;
RT "The FXYD gene family of small ion transport regulators or channels: cDNA
RT sequence, protein signature sequence, and expression.";
RL Genomics 68:41-56(2000).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Spleen, lung, skeletal muscle, and testis.
CC -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000305}.
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DR EMBL; BC060571; AAH60571.1; -; mRNA.
DR RefSeq; NP_001257617.1; NM_001270688.1.
DR RefSeq; NP_001257618.1; NM_001270689.1.
DR RefSeq; NP_068709.2; NM_021909.2.
DR AlphaFoldDB; P59647; -.
DR STRING; 10116.ENSRNOP00000028597; -.
DR PaxDb; P59647; -.
DR GeneID; 60338; -.
DR KEGG; rno:60338; -.
DR CTD; 53827; -.
DR RGD; 620827; Fxyd5.
DR VEuPathDB; HostDB:ENSRNOG00000021062; -.
DR eggNOG; ENOG502TDJN; Eukaryota.
DR HOGENOM; CLU_109413_0_0_1; -.
DR InParanoid; P59647; -.
DR OMA; ATPNQME; -.
DR OrthoDB; 1455172at2759; -.
DR PhylomeDB; P59647; -.
DR TreeFam; TF338182; -.
DR PRO; PR:P59647; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000021062; Expressed in spleen and 20 other tissues.
DR Genevisible; P59647; RN.
DR GO; GO:0016021; C:integral component of membrane; ISO:RGD.
DR GO; GO:0003779; F:actin binding; ISO:RGD.
DR GO; GO:0045296; F:cadherin binding; ISO:RGD.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0043269; P:regulation of ion transport; IEA:InterPro.
DR InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR PROSITE; PS01310; FXYD; 1.
PE 2: Evidence at transcript level;
KW Ion channel; Ion transport; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..178
FT /note="FXYD domain-containing ion transport regulator 5"
FT /id="PRO_0000010371"
FT TOPO_DOM 22..146
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..178
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 21..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 178 AA; 19128 MW; 99B30D88B928FF4E CRC64;
MSPPSQLCLL TIVALILPSE GQTPEKPRSS FTAHQSSVTT HVPVPDQTSP GVQTTPPIWT
SEAGEATGSQ TAAKTKTQQL TEMATANPVT DPGPLTSSEK GTPALSRIKS PSPPKGYMPP
SYIENPLDPN ENSPFYYDNT TLRKRGLLVA AVLFITGIII LTSGKCRQFS QLCLNRHR
