ID   FXYD6_BOVIN             Reviewed;          95 AA.
AC   Q3MHZ5;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=FXYD domain-containing ion transport regulator 6;
DE   AltName: Full=Phosphohippolin;
DE   Flags: Precursor;
GN   Name=FXYD6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC104508; AAI04509.1; -; mRNA.
DR   RefSeq; NP_001029571.1; NM_001034399.1.
DR   RefSeq; XP_005215879.1; XM_005215822.1.
DR   RefSeq; XP_015330097.1; XM_015474611.1.
DR   RefSeq; XP_015330098.1; XM_015474612.1.
DR   AlphaFoldDB; Q3MHZ5; -.
DR   SMR; Q3MHZ5; -.
DR   STRING; 9913.ENSBTAP00000039832; -.
DR   PaxDb; Q3MHZ5; -.
DR   Ensembl; ENSBTAT00000040049; ENSBTAP00000039832; ENSBTAG00000014354.
DR   GeneID; 511064; -.
DR   KEGG; bta:511064; -.
DR   CTD; 53826; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014354; -.
DR   VGNC; VGNC:54871; FXYD6.
DR   eggNOG; ENOG502S570; Eukaryota.
DR   GeneTree; ENSGT00940000153062; -.
DR   HOGENOM; CLU_171208_3_0_1; -.
DR   InParanoid; Q3MHZ5; -.
DR   OMA; ETDPFHY; -.
DR   OrthoDB; 1524217at2759; -.
DR   TreeFam; TF333443; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000014354; Expressed in parenchyma of mammary gland and 106 other tissues.
DR   ExpressionAtlas; Q3MHZ5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0043269; P:regulation of ion transport; IEA:InterPro.
DR   InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR   Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR   PROSITE; PS01310; FXYD; 1.
PE   3: Inferred from homology;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250|UniProtKB:Q91XV6"
FT   CHAIN           19..95
FT                   /note="FXYD domain-containing ion transport regulator 6"
FT                   /id="PRO_0000230994"
FT   TOPO_DOM        19..35
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59..95
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          69..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..95
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   95 AA;  10465 MW;  997C21AD532C13CB CRC64;
     MEVVLLFLCG LLAPAVLASA TEQEKEKDPF HYDYQTLRIG GLVFAVVLFS VGILLILSRR
     CKCSFNQKPR APGDEEAQVE NLVTANATEP QKAEN