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FXYD6_HUMAN
ID   FXYD6_HUMAN             Reviewed;          95 AA.
AC   Q9H0Q3; A8K0R4; J3QLD2; Q6FIG9; Q6UW52;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 176.
DE   RecName: Full=FXYD domain-containing ion transport regulator 6;
DE   AltName: Full=Phosphohippolin;
DE   Flags: Precursor;
GN   Name=FXYD6; ORFNames=UNQ521/PRO1056;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA   Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA   Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA   Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA   Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA   Klein M., Poustka A.;
RT   "Towards a catalog of human genes and proteins: sequencing and analysis of
RT   500 novel complete protein coding human cDNAs.";
RL   Genome Res. 11:422-435(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Embryonic stem cell;
RX   PubMed=15146197; DOI=10.1038/nbt971;
RA   Brandenberger R., Wei H., Zhang S., Lei S., Murage J., Fisk G.J., Li Y.,
RA   Xu C., Fang R., Guegler K., Rao M.S., Mandalam R., Lebkowski J.,
RA   Stanton L.W.;
RT   "Transcriptome characterization elucidates signaling networks that control
RT   human ES cell growth and differentiation.";
RL   Nat. Biotechnol. 22:707-716(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Amygdala;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lymph node;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lung, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q9H0Q3; Q8NCL9: APCDD1L; NbExp=3; IntAct=EBI-713304, EBI-12904424;
CC       Q9H0Q3; Q96BI3: APH1A; NbExp=3; IntAct=EBI-713304, EBI-2606935;
CC       Q9H0Q3; Q13520: AQP6; NbExp=3; IntAct=EBI-713304, EBI-13059134;
CC       Q9H0Q3; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-713304, EBI-11343438;
CC       Q9H0Q3; P04233-2: CD74; NbExp=3; IntAct=EBI-713304, EBI-12222807;
CC       Q9H0Q3; Q9HA82: CERS4; NbExp=3; IntAct=EBI-713304, EBI-2622997;
CC       Q9H0Q3; O95471: CLDN7; NbExp=3; IntAct=EBI-713304, EBI-740744;
CC       Q9H0Q3; Q8IUN9: CLEC10A; NbExp=3; IntAct=EBI-713304, EBI-2873246;
CC       Q9H0Q3; Q96BA8: CREB3L1; NbExp=6; IntAct=EBI-713304, EBI-6942903;
CC       Q9H0Q3; Q9GZP9: DERL2; NbExp=3; IntAct=EBI-713304, EBI-7962814;
CC       Q9H0Q3; Q15125: EBP; NbExp=3; IntAct=EBI-713304, EBI-3915253;
CC       Q9H0Q3; Q9NXB9: ELOVL2; NbExp=3; IntAct=EBI-713304, EBI-17206972;
CC       Q9H0Q3; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-713304, EBI-18535450;
CC       Q9H0Q3; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-713304, EBI-781551;
CC       Q9H0Q3; O15552: FFAR2; NbExp=3; IntAct=EBI-713304, EBI-2833872;
CC       Q9H0Q3; P25090: FPR2; NbExp=3; IntAct=EBI-713304, EBI-17291771;
CC       Q9H0Q3; P48165: GJA8; NbExp=3; IntAct=EBI-713304, EBI-17458373;
CC       Q9H0Q3; O15529: GPR42; NbExp=3; IntAct=EBI-713304, EBI-18076404;
CC       Q9H0Q3; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-713304, EBI-10266796;
CC       Q9H0Q3; P48051: KCNJ6; NbExp=3; IntAct=EBI-713304, EBI-12017638;
CC       Q9H0Q3; Q6ZUX7: LHFPL2; NbExp=3; IntAct=EBI-713304, EBI-17566767;
CC       Q9H0Q3; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-713304, EBI-2820517;
CC       Q9H0Q3; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-713304, EBI-11956541;
CC       Q9H0Q3; O14880: MGST3; NbExp=3; IntAct=EBI-713304, EBI-724754;
CC       Q9H0Q3; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-713304, EBI-6163737;
CC       Q9H0Q3; Q9NX40: OCIAD1; NbExp=3; IntAct=EBI-713304, EBI-2683029;
CC       Q9H0Q3; O00623: PEX12; NbExp=3; IntAct=EBI-713304, EBI-594836;
CC       Q9H0Q3; O15173: PGRMC2; NbExp=3; IntAct=EBI-713304, EBI-1050125;
CC       Q9H0Q3; O75783: RHBDL1; NbExp=3; IntAct=EBI-713304, EBI-12104986;
CC       Q9H0Q3; Q9UBD6: RHCG; NbExp=3; IntAct=EBI-713304, EBI-15853497;
CC       Q9H0Q3; Q6P5S7: RNASEK; NbExp=3; IntAct=EBI-713304, EBI-18397230;
CC       Q9H0Q3; Q14973: SLC10A1; NbExp=3; IntAct=EBI-713304, EBI-3923031;
CC       Q9H0Q3; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-713304, EBI-18159983;
CC       Q9H0Q3; O60669: SLC16A7; NbExp=3; IntAct=EBI-713304, EBI-3921243;
CC       Q9H0Q3; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-713304, EBI-8644112;
CC       Q9H0Q3; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-713304, EBI-17295964;
CC       Q9H0Q3; Q7Z769: SLC35E3; NbExp=3; IntAct=EBI-713304, EBI-13389236;
CC       Q9H0Q3; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-713304, EBI-12898013;
CC       Q9H0Q3; Q96FL8: SLC47A1; NbExp=3; IntAct=EBI-713304, EBI-12887226;
CC       Q9H0Q3; Q8N4V2: SVOP; NbExp=4; IntAct=EBI-713304, EBI-12883142;
CC       Q9H0Q3; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-713304, EBI-12947623;
CC       Q9H0Q3; Q96CE8: TM4SF18; NbExp=3; IntAct=EBI-713304, EBI-13351685;
CC       Q9H0Q3; Q6P9G4: TMEM154; NbExp=3; IntAct=EBI-713304, EBI-13329239;
CC       Q9H0Q3; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-713304, EBI-10982110;
CC       Q9H0Q3; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-713304, EBI-11528917;
CC       Q9H0Q3; Q53FP2: TMEM35A; NbExp=3; IntAct=EBI-713304, EBI-11722971;
CC       Q9H0Q3; A0PK05: TMEM72; NbExp=3; IntAct=EBI-713304, EBI-12878352;
CC       Q9H0Q3; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-713304, EBI-2548832;
CC       Q9H0Q3; Q6ZT21: TMPPE; NbExp=3; IntAct=EBI-713304, EBI-11724433;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9H0Q3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9H0Q3-2; Sequence=VSP_045996;
CC   -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAQ89335.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AL136699; CAB66634.1; -; mRNA.
DR   EMBL; AY358976; AAQ89335.1; ALT_FRAME; mRNA.
DR   EMBL; BT006717; AAP35363.1; -; mRNA.
DR   EMBL; CN310658; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; CR533457; CAG38488.1; -; mRNA.
DR   EMBL; AK289629; BAF82318.1; -; mRNA.
DR   EMBL; AK290757; BAF83446.1; -; mRNA.
DR   EMBL; AL832811; CAI46171.1; -; mRNA.
DR   EMBL; AP000757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471065; EAW67327.1; -; Genomic_DNA.
DR   EMBL; BC018652; AAH18652.1; -; mRNA.
DR   EMBL; BC093040; AAH93040.1; -; mRNA.
DR   CCDS; CCDS8387.1; -. [Q9H0Q3-1]
DR   RefSeq; NP_001158303.1; NM_001164831.2. [Q9H0Q3-1]
DR   RefSeq; NP_001158304.1; NM_001164832.2. [Q9H0Q3-1]
DR   RefSeq; NP_001158308.1; NM_001164836.2. [Q9H0Q3-1]
DR   RefSeq; NP_001158309.1; NM_001164837.2. [Q9H0Q3-1]
DR   RefSeq; NP_071286.1; NM_022003.3. [Q9H0Q3-1]
DR   AlphaFoldDB; Q9H0Q3; -.
DR   SMR; Q9H0Q3; -.
DR   BioGRID; 119799; 92.
DR   BioGRID; 1529426; 33.
DR   IntAct; Q9H0Q3; 70.
DR   MINT; Q9H0Q3; -.
DR   TCDB; 1.A.27.1.3; the phospholemman (plm) family.
DR   iPTMnet; Q9H0Q3; -.
DR   PhosphoSitePlus; Q9H0Q3; -.
DR   SwissPalm; Q9H0Q3; -.
DR   BioMuta; FXYD6; -.
DR   DMDM; 20138342; -.
DR   EPD; Q9H0Q3; -.
DR   jPOST; Q9H0Q3; -.
DR   MassIVE; Q9H0Q3; -.
DR   MaxQB; Q9H0Q3; -.
DR   PaxDb; Q9H0Q3; -.
DR   PeptideAtlas; Q9H0Q3; -.
DR   PRIDE; Q9H0Q3; -.
DR   ProteomicsDB; 80311; -. [Q9H0Q3-1]
DR   Antibodypedia; 45759; 132 antibodies from 22 providers.
DR   DNASU; 53826; -.
DR   Ensembl; ENST00000260282.8; ENSP00000260282.4; ENSG00000137726.17. [Q9H0Q3-1]
DR   Ensembl; ENST00000524656.5; ENSP00000431427.1; ENSG00000137726.17. [Q9H0Q3-1]
DR   Ensembl; ENST00000526014.6; ENSP00000433312.1; ENSG00000137726.17. [Q9H0Q3-1]
DR   Ensembl; ENST00000527717.5; ENSP00000431446.1; ENSG00000137726.17. [Q9H0Q3-1]
DR   Ensembl; ENST00000530956.6; ENSP00000463158.1; ENSG00000137726.17. [Q9H0Q3-1]
DR   Ensembl; ENST00000539526.5; ENSP00000442756.1; ENSG00000137726.17. [Q9H0Q3-1]
DR   GeneID; 53826; -.
DR   KEGG; hsa:53826; -.
DR   MANE-Select; ENST00000526014.6; ENSP00000433312.1; NM_022003.4; NP_071286.1.
DR   UCSC; uc001pro.3; human. [Q9H0Q3-1]
DR   CTD; 53826; -.
DR   DisGeNET; 53826; -.
DR   GeneCards; FXYD6; -.
DR   HGNC; HGNC:4030; FXYD6.
DR   HPA; ENSG00000137726; Low tissue specificity.
DR   MIM; 606683; gene.
DR   neXtProt; NX_Q9H0Q3; -.
DR   OpenTargets; ENSG00000137726; -.
DR   OpenTargets; ENSG00000255245; -.
DR   PharmGKB; PA28446; -.
DR   VEuPathDB; HostDB:ENSG00000137726; -.
DR   GeneTree; ENSGT00940000153062; -.
DR   HOGENOM; CLU_171208_3_0_1; -.
DR   InParanoid; Q9H0Q3; -.
DR   OMA; ETDPFHY; -.
DR   PhylomeDB; Q9H0Q3; -.
DR   TreeFam; TF333443; -.
DR   PathwayCommons; Q9H0Q3; -.
DR   Reactome; R-HSA-5578775; Ion homeostasis.
DR   Reactome; R-HSA-936837; Ion transport by P-type ATPases.
DR   Reactome; R-HSA-9679191; Potential therapeutics for SARS.
DR   SignaLink; Q9H0Q3; -.
DR   BioGRID-ORCS; 53826; 15 hits in 1005 CRISPR screens.
DR   ChiTaRS; FXYD6; human.
DR   GenomeRNAi; 53826; -.
DR   Pharos; Q9H0Q3; Tbio.
DR   PRO; PR:Q9H0Q3; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9H0Q3; protein.
DR   Bgee; ENSG00000137726; Expressed in cortical plate and 202 other tissues.
DR   ExpressionAtlas; Q9H0Q3; baseline and differential.
DR   Genevisible; Q9H0Q3; HS.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0099055; C:integral component of postsynaptic membrane; IEA:Ensembl.
DR   GO; GO:0099056; C:integral component of presynaptic membrane; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IDA:LIFEdb.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0043269; P:regulation of ion transport; IEA:InterPro.
DR   InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR   Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR   PROSITE; PS01310; FXYD; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Ion channel; Ion transport; Membrane;
KW   Reference proteome; Schizophrenia; Signal; Transmembrane;
KW   Transmembrane helix; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250|UniProtKB:Q91XV6"
FT   CHAIN           19..95
FT                   /note="FXYD domain-containing ion transport regulator 6"
FT                   /id="PRO_0000010372"
FT   TOPO_DOM        19..35
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59..95
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          69..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..95
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         58..95
FT                   /note="SRRCKCSFNQKPRAPGDEEAQVENLITANATEPQKAEN -> RPQEMRKPRW
FT                   RTSSPPMQQSPRKQRTEVQPSGGRRQPQGGRGPVLLWQKIPLWGQ (in isoform
FT                   2)"
FT                   /evidence="ECO:0000303|PubMed:15146197"
FT                   /id="VSP_045996"
SQ   SEQUENCE   95 AA;  10542 MW;  3F083146A42422CE CRC64;
     MELVLVFLCS LLAPMVLASA AEKEKEMDPF HYDYQTLRIG GLVFAVVLFS VGILLILSRR
     CKCSFNQKPR APGDEEAQVE NLITANATEP QKAEN
 
 
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