FXYD6_RAT
ID FXYD6_RAT Reviewed; 94 AA.
AC Q91XV6; Q9JLR4;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=FXYD domain-containing ion transport regulator 6;
DE AltName: Full=Phosphohippolin;
DE AltName: Full=Vascular endothelial cell-specific protein 6;
DE Short=VESP6;
DE Flags: Precursor;
GN Name=Fxyd6; Synonyms=Php;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Liver;
RA Aoki T., Toyoda H., Nishimoto S., Tawara J., Komurasaki T.;
RT "Identification of VESP6, a vascular endothelial cell specific protein.";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley; TISSUE=Hippocampus;
RX PubMed=11165386; DOI=10.1016/s0169-328x(00)00213-8;
RA Yamaguchi F., Yamaguchi K., Tai Y., Sugimoto K., Tokuda M.;
RT "Molecular cloning and characterization of a novel phospholemman-like
RT protein from rat hippocampus.";
RL Brain Res. Mol. Brain Res. 86:189-192(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 25-37, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RA Lubec G., Kang S.U., Lubec S.;
RL Submitted (SEP-2007) to UniProtKB.
RN [5]
RP CLEAVAGE OF SIGNAL PEPTIDE AFTER ALA-17, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=26479776; DOI=10.1021/acs.jproteome.5b00820;
RA Tsuchiya T., Osaki T., Minamino N., Sasaki K.;
RT "Peptidomics for studying limited proteolysis.";
RL J. Proteome Res. 14:4921-4931(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q91XV6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q91XV6-2; Sequence=VSP_001586;
CC -!- TISSUE SPECIFICITY: Expressed in the neuronal fibers of the medial part
CC of lateral habenula nucleus, thalamus, hypothalamus, stria terminalis,
CC zona incerta, amygdaloid body and cingulum, olfactory bulb,
CC hippocampus, cerebral cortex and cerebellum. In the cerebellum there is
CC a predominant expression pattern in the granule layer of lobules VI-IX
CC of the posterior lobe. {ECO:0000269|PubMed:11165386}.
CC -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000305}.
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DR EMBL; AB030908; BAB62242.1; -; mRNA.
DR EMBL; AF142439; AAF66613.1; -; mRNA.
DR EMBL; BC072528; AAH72528.1; -; mRNA.
DR RefSeq; NP_071288.1; NM_022005.2. [Q91XV6-1]
DR RefSeq; XP_008764393.1; XM_008766171.2. [Q91XV6-2]
DR AlphaFoldDB; Q91XV6; -.
DR SMR; Q91XV6; -.
DR BioGRID; 248902; 1.
DR STRING; 10116.ENSRNOP00000022032; -.
DR SwissPalm; Q91XV6; -.
DR jPOST; Q91XV6; -.
DR PaxDb; Q91XV6; -.
DR PRIDE; Q91XV6; -.
DR GeneID; 63847; -.
DR KEGG; rno:63847; -.
DR UCSC; RGD:69315; rat. [Q91XV6-1]
DR CTD; 53826; -.
DR RGD; 69315; Fxyd6.
DR VEuPathDB; HostDB:ENSRNOG00000016412; -.
DR eggNOG; ENOG502S570; Eukaryota.
DR HOGENOM; CLU_171208_3_0_1; -.
DR InParanoid; Q91XV6; -.
DR OMA; ETDPFHY; -.
DR OrthoDB; 1524217at2759; -.
DR PhylomeDB; Q91XV6; -.
DR TreeFam; TF333443; -.
DR Reactome; R-RNO-5578775; Ion homeostasis.
DR Reactome; R-RNO-936837; Ion transport by P-type ATPases.
DR PRO; PR:Q91XV6; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000016412; Expressed in frontal cortex and 20 other tissues.
DR ExpressionAtlas; Q91XV6; baseline and differential.
DR Genevisible; Q91XV6; RN.
DR GO; GO:0098978; C:glutamatergic synapse; ISO:RGD.
DR GO; GO:0099055; C:integral component of postsynaptic membrane; ISO:RGD.
DR GO; GO:0099056; C:integral component of presynaptic membrane; ISO:RGD.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0043269; P:regulation of ion transport; IEA:InterPro.
DR InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR PROSITE; PS01310; FXYD; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Direct protein sequencing; Ion channel;
KW Ion transport; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..17
FT /evidence="ECO:0000269|PubMed:26479776"
FT CHAIN 18..94
FT /note="FXYD domain-containing ion transport regulator 6"
FT /id="PRO_0000010376"
FT TOPO_DOM 18..34
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..94
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 20
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11165386"
FT /id="VSP_001586"
FT CONFLICT 65
FT /note="N -> S (in Ref. 2; AAF66613)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 94 AA; 10388 MW; 1C0D35FA0C572451 CRC64;
METVLILCSL LAPVVLASAA EKEKEKDPFY YDYQTLRIGG LVFAVVLFSV GILLILSRRC
KCSFNQKPRA PGDEEAQVEN LITTNAAEPQ KAEN
