ID   FXYD7_HUMAN             Reviewed;          80 AA.
AC   P58549;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=FXYD domain-containing ion transport regulator 7;
GN   Name=FXYD7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       P58549; Q92624: APPBP2; NbExp=6; IntAct=EBI-10216171, EBI-743771;
CC       P58549; O43765: SGTA; NbExp=8; IntAct=EBI-10216171, EBI-347996;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000305}.
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DR   EMBL; BC018619; AAH18619.1; -; mRNA.
DR   CCDS; CCDS12446.1; -.
DR   RefSeq; NP_071289.1; NM_022006.1.
DR   AlphaFoldDB; P58549; -.
DR   SMR; P58549; -.
DR   BioGRID; 119795; 5.
DR   IntAct; P58549; 2.
DR   STRING; 9606.ENSP00000270310; -.
DR   TCDB; 1.A.27.1.7; the phospholemman (plm) family.
DR   iPTMnet; P58549; -.
DR   PhosphoSitePlus; P58549; -.
DR   BioMuta; FXYD7; -.
DR   DMDM; 20138168; -.
DR   jPOST; P58549; -.
DR   MassIVE; P58549; -.
DR   PaxDb; P58549; -.
DR   PeptideAtlas; P58549; -.
DR   PRIDE; P58549; -.
DR   ProteomicsDB; 57088; -.
DR   Antibodypedia; 21550; 190 antibodies from 27 providers.
DR   DNASU; 53822; -.
DR   Ensembl; ENST00000270310.7; ENSP00000270310.2; ENSG00000221946.8.
DR   GeneID; 53822; -.
DR   KEGG; hsa:53822; -.
DR   MANE-Select; ENST00000270310.7; ENSP00000270310.2; NM_022006.2; NP_071289.1.
DR   UCSC; uc002nye.2; human.
DR   CTD; 53822; -.
DR   GeneCards; FXYD7; -.
DR   HGNC; HGNC:4034; FXYD7.
DR   HPA; ENSG00000221946; Tissue enriched (brain).
DR   MIM; 606684; gene.
DR   neXtProt; NX_P58549; -.
DR   OpenTargets; ENSG00000221946; -.
DR   PharmGKB; PA28450; -.
DR   VEuPathDB; HostDB:ENSG00000221946; -.
DR   eggNOG; ENOG502SFZR; Eukaryota.
DR   GeneTree; ENSGT00940000153062; -.
DR   HOGENOM; CLU_168385_1_0_1; -.
DR   InParanoid; P58549; -.
DR   OMA; SKCNPFL; -.
DR   OrthoDB; 1630491at2759; -.
DR   PhylomeDB; P58549; -.
DR   TreeFam; TF333443; -.
DR   PathwayCommons; P58549; -.
DR   Reactome; R-HSA-5578775; Ion homeostasis.
DR   Reactome; R-HSA-936837; Ion transport by P-type ATPases.
DR   Reactome; R-HSA-9679191; Potential therapeutics for SARS.
DR   SignaLink; P58549; -.
DR   BioGRID-ORCS; 53822; 14 hits in 1072 CRISPR screens.
DR   GenomeRNAi; 53822; -.
DR   Pharos; P58549; Tbio.
DR   PRO; PR:P58549; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; P58549; protein.
DR   Bgee; ENSG00000221946; Expressed in primary visual cortex and 91 other tissues.
DR   ExpressionAtlas; P58549; baseline and differential.
DR   Genevisible; P58549; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0043269; P:regulation of ion transport; IEA:InterPro.
DR   InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR   Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR   PROSITE; PS01310; FXYD; 1.
PE   1: Evidence at protein level;
KW   Ion channel; Ion transport; Membrane; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..80
FT                   /note="FXYD domain-containing ion transport regulator 7"
FT                   /id="PRO_0000148190"
FT   TRANSMEM        24..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          54..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         73
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P59649"
SQ   SEQUENCE   80 AA;  8524 MW;  130DAC482EFF1939 CRC64;
     MATPTQTPTK APEEPDPFYY DYNTVQTVGM TLATILFLLG ILIVISKKVK CRKADSRSES
     PTCKSCKSEL PSSAPGGGGV