FYRI_ANTEL
ID FYRI_ANTEL Reviewed; 4 AA.
AC P58706;
DT 31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2002, sequence version 1.
DT 11-DEC-2019, entry version 37.
DE RecName: Full=Antho-RIamide-1;
DE AltName: Full=Antho-RIamide I;
DE Contains:
DE RecName: Full=Antho-RIamide-2;
DE AltName: Full=Antho-RIamide II;
OS Anthopleura elegantissima (Green aggregating anemone) (Actinia
OS elegantissima).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Actiniidae; Anthopleura.
OX NCBI_TaxID=6110;
RN [1]
RP PROTEIN SEQUENCE, AND AMIDATION AT ILE-4.
RX PubMed=1821096; DOI=10.1016/0196-9781(91)90190-z;
RA Nothacker H.-P., Rinehart K.L. Jr., McFarlane I.D.,
RA Grimmelikhuijzen C.J.P.;
RT "Isolation of two novel neuropeptides from sea anemones: the unusual,
RT biologically active L-3-phenyllactyl-Tyr-Arg-Ile-NH2 and its des-
RT phenyllactyl fragment Tyr-Arg-Ile-NH2.";
RL Peptides 12:1165-1173(1991).
RN [2]
RP FUNCTION.
RX PubMed=8397415; DOI=10.1098/rspb.1993.0100;
RA McFarlane I.D., Hudman D., Nothacker H.-P., Grimmelikhuijzen C.J.P.;
RT "The expansion behaviour of sea anemones may be coordinated by two
RT inhibitory neuropeptides, Antho-KAamide and Antho-RIamide.";
RL Proc. R. Soc. B 253:183-188(1993).
CC -!- FUNCTION: Inhibits spontaneous contractions in several muscle groups.
CC May be involved in the expansion phase of feeding behavior in sea
CC anemones. {ECO:0000269|PubMed:8397415}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Neuron specific.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT PEPTIDE 1..4
FT /note="Antho-RIamide-1"
FT /id="PRO_0000009891"
FT PEPTIDE 2..4
FT /note="Antho-RIamide-2"
FT /id="PRO_0000009892"
FT MOD_RES 1
FT /note="3-phenyllactic acid"
FT MOD_RES 4
FT /note="Isoleucine amide"
FT /evidence="ECO:0000269|PubMed:1821096"
SQ SEQUENCE 4 AA; 598 MW; 60441B59A0000000 CRC64;
FYRI