ID   FYUA_YEREN              Reviewed;         673 AA.
AC   P0C2M9; P46360;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Pesticin receptor;
DE   AltName: Full=IPR65;
DE   AltName: Full=IRPC;
DE   Flags: Precursor;
GN   Name=fyuA;
OS   Yersinia enterocolitica.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 51871 / WA-314 / Serotype O:8;
RX   PubMed=7984105; DOI=10.1111/j.1365-2958.1994.tb00420.x;
RA   Rakin A., Saken E., Harmsen D., Heesemann J.;
RT   "The pesticin receptor of Yersinia enterocolitica: a novel virulence factor
RT   with dual function.";
RL   Mol. Microbiol. 13:253-263(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1209-79 / Serotype O:13, 1223-75-1 / Serotype O:20, and
RC   YE737 / Serotype O:21;
RX   PubMed=7730256; DOI=10.1128/jb.177.9.2292-2298.1995;
RA   Rakin A., Urbitsch P., Heesemann J.;
RT   "Evidence for two evolutionary lineages of highly pathogenic Yersinia
RT   species.";
RL   J. Bacteriol. 177:2292-2298(1995).
RN   [3]
RP   EXPRESSION.
RC   STRAIN=ATCC 51872 / WA-C / Serotype O:8;
RX   PubMed=11705959; DOI=10.1128/iai.69.12.7772-7782.2001;
RA   Jacobi C.A., Gregor S., Rakin A., Heesemann J.;
RT   "Expression analysis of the yersiniabactin receptor gene fyuA and the heme
RT   receptor hemR of Yersinia enterocolitica in vitro and in vivo using the
RT   reporter genes for green fluorescent protein and luciferase.";
RL   Infect. Immun. 69:7772-7782(2001).
CC   -!- FUNCTION: Receptor for the bacteriocin pesticin and for the siderophore
CC       yersiniabactin.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- INDUCTION: Induced in absence of iron.
CC   -!- MISCELLANEOUS: Weakly expressed by yersiniae located in the liver and
CC       the intestinal lumen. Strongly expressed in yersiniae located in the
CC       peritoneal cavity. Moderately expressed in yersiniae located in the
CC       spleen. This probably reflects the availability of iron for yersiniae.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; Z29675; CAA82773.1; -; Genomic_DNA.
DR   EMBL; Z35485; CAA84620.1; -; Genomic_DNA.
DR   EMBL; Z35487; CAA84622.1; -; Genomic_DNA.
DR   EMBL; Z35496; CAA84630.1; -; Genomic_DNA.
DR   PIR; S60142; S60142.
DR   RefSeq; WP_005168662.1; NZ_CQCV01000030.1.
DR   RefSeq; WP_011816644.1; NZ_NWMR01000021.1.
DR   AlphaFoldDB; P0C2M9; -.
DR   SMR; P0C2M9; -.
DR   TCDB; 1.B.14.8.7; the outer membrane receptor (omr) family.
DR   KEGG; yew:CH47_1968; -.
DR   OrthoDB; 514956at2; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010105; TonB_sidphr_rcpt.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01783; TonB-siderophor; 1.
PE   2: Evidence at transcript level;
KW   Cell outer membrane; Ion transport; Iron; Iron transport; Membrane;
KW   Receptor; Signal; TonB box; Transmembrane; Transmembrane beta strand;
KW   Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..673
FT                   /note="Pesticin receptor"
FT                   /id="PRO_0000034756"
FT   MOTIF           30..37
FT                   /note="TonB box"
FT   MOTIF           657..673
FT                   /note="TonB C-terminal box"
FT   VARIANT         362
FT                   /note="N -> D (in strain: YE737 and 1209-79)"
SQ   SEQUENCE   673 AA;  73682 MW;  1C20E0352FAD4DCC CRC64;
     MKMTRLYPLA LGGLLLPAIA NAQTSQQDES TLEVTASKQS SRSASANNVS STVVSAPELS
     DAGVTASDKL PRVLPGLNIE NSGNMLFSTI SLRGVSSAQD FYNPAVTLYV DGVPQLSTNT
     IQALTDVQSV ELLRGPQGTL YGKSAQGGII NIVTQQPDST PRGYIEGGVS SRDSYRSKFN
     LSGPIQDGLL YGSVTLLRQV DDGDMINPAT GSDDLGGTRA SIGNVKLRLA PDDQPWEMGF
     AASRECTRAT QDAYVGWNDI KGRKLSLSDG SPDPYMRRCT DSQTLSGKYT TDDWVFNLIS
     AWQQQHYSRT FPSGSLIVNM PQRWNQDVQE LRAATLGDAR TVDMVFGLYR QNTREKLNSA
     YNMPTMPYLS STGYTTAETL AAYSDLTWHL TDRFDIGGGV RFSHDKSSTQ YHGSMLGNPF
     GDQGKSNDDQ VLGQLSAGYM LTDDWRVYTR IAQGYKPSGY NIVPTAGLDA KPFVAEKSIN
     YELGTRYETA DVTLQAATFY THTKDMQLYS GPVGMQTLSN AGKADATGVE LEAKWRFAPG
     WSWDINGNVI RSEFTNDSEL YHGNRVPFVP RYGAGSSVNG VIDTRYGALM PRLAVNLVGP
     HYFDGDNQLR QGTYATLDSS LGWQATERIN ISVHVDNLFD RRYRTYGYMN GSSAVAQVNM
     GRTVGINTRI DFF