FYUA_YERPE
ID FYUA_YERPE Reviewed; 673 AA.
AC P46359; Q0WFP1;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2001, sequence version 2.
DT 25-MAY-2022, entry version 154.
DE RecName: Full=Pesticin receptor;
DE AltName: Full=IRPC;
DE Flags: Precursor;
GN Name=fyuA; Synonyms=psn; OrderedLocusNames=YPO1906, y2404, YP_1649;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=6/69;
RA Rakin A., Heesemann J.;
RL Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM6;
RX PubMed=7896707; DOI=10.1128/jb.177.7.1824-1833.1995;
RA Fetherston J.D., Lillard J.W., Perry R.D.;
RT "Analysis of the pesticin receptor from Yersinia pestis: role in iron-
RT deficient growth and possible regulation by its siderophore.";
RL J. Bacteriol. 177:1824-1833(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM6;
RX PubMed=9818149; DOI=10.1016/s1074-5521(98)90115-6;
RA Gehring A.M., DeMoll E., Fetherston J.D., Mori I., Mayhew G.F.,
RA Blattner F.R., Walsh C.T., Perry R.D.;
RT "Iron acquisition in plague: modular logic in enzymatic biogenesis of
RT yersiniabactin by Yersinia pestis.";
RL Chem. Biol. 5:573-586(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=6/69;
RA Buchrieser C., Rusniok C., Couve E., Frangeul L., Billault A., Kunst F.,
RA Carniel E., Glaser P.;
RT "DNA sequence of the 102 kbases unstable region of Yersinia pestis.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Receptor for the bacteriocin pesticin and for the siderophore
CC yersiniabactin.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC -!- INDUCTION: By iron starvation. Iron regulation mediated through the Fur
CC protein.
CC -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC {ECO:0000305}.
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DR EMBL; Z35104; CAA84487.1; -; Genomic_DNA.
DR EMBL; U09530; AAA69906.1; -; Genomic_DNA.
DR EMBL; AF091251; AAC69592.1; -; Genomic_DNA.
DR EMBL; AL031866; CAA21395.1; -; Genomic_DNA.
DR EMBL; AL590842; CAL20545.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM85962.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS61879.1; -; Genomic_DNA.
DR PIR; A56148; A56148.
DR PIR; AF0232; AF0232.
DR RefSeq; WP_002212885.1; NZ_WUCM01000003.1.
DR RefSeq; YP_002346897.1; NC_003143.1.
DR PDB; 4EPA; X-ray; 3.20 A; A=23-673.
DR PDBsum; 4EPA; -.
DR AlphaFoldDB; P46359; -.
DR SMR; P46359; -.
DR IntAct; P46359; 5.
DR STRING; 214092.YPO1906; -.
DR PaxDb; P46359; -.
DR PRIDE; P46359; -.
DR EnsemblBacteria; AAM85962; AAM85962; y2404.
DR EnsemblBacteria; AAS61879; AAS61879; YP_1649.
DR KEGG; ype:YPO1906; -.
DR KEGG; ypk:y2404; -.
DR KEGG; ypm:YP_1649; -.
DR PATRIC; fig|214092.21.peg.2277; -.
DR eggNOG; COG4771; Bacteria.
DR HOGENOM; CLU_008287_15_2_6; -.
DR OMA; GGYNIQM; -.
DR PHI-base; PHI:4955; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031230; C:intrinsic component of cell outer membrane; IBA:GO_Central.
DR GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0044718; P:siderophore transmembrane transport; IBA:GO_Central.
DR Gene3D; 2.40.170.20; -; 1.
DR InterPro; IPR039426; BtuB-like.
DR InterPro; IPR012910; Plug_dom.
DR InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR InterPro; IPR010105; TonB_sidphr_rcpt.
DR PANTHER; PTHR30069; PTHR30069; 1.
DR Pfam; PF07715; Plug; 1.
DR Pfam; PF00593; TonB_dep_Rec; 1.
DR TIGRFAMs; TIGR01783; TonB-siderophor; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Ion transport; Iron; Iron transport;
KW Membrane; Receptor; Reference proteome; Signal; TonB box; Transmembrane;
KW Transmembrane beta strand; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..673
FT /note="Pesticin receptor"
FT /id="PRO_0000034757"
FT MOTIF 30..37
FT /note="TonB box"
FT MOTIF 657..673
FT /note="TonB C-terminal box"
FT CONFLICT 484
FT /note="G -> D (in Ref. 1; CAA84487)"
FT /evidence="ECO:0000305"
FT CONFLICT 514
FT /note="R -> G (in Ref. 1 and 7)"
FT /evidence="ECO:0000305"
FT STRAND 37..39
FT /evidence="ECO:0007829|PDB:4EPA"
FT HELIX 44..47
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 51..55
FT /evidence="ECO:0007829|PDB:4EPA"
FT HELIX 56..61
FT /evidence="ECO:0007829|PDB:4EPA"
FT HELIX 67..72
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 81..84
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 105..110
FT /evidence="ECO:0007829|PDB:4EPA"
FT HELIX 117..119
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 126..135
FT /evidence="ECO:0007829|PDB:4EPA"
FT TURN 138..141
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 146..154
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 162..170
FT /evidence="ECO:0007829|PDB:4EPA"
FT HELIX 171..173
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 174..186
FT /evidence="ECO:0007829|PDB:4EPA"
FT TURN 187..189
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 190..201
FT /evidence="ECO:0007829|PDB:4EPA"
FT TURN 208..210
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 218..229
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 234..249
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 275..285
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 288..290
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 295..313
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 316..319
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 322..334
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 341..362
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 364..389
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 391..415
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 418..442
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 445..452
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 466..468
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 476..488
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 490..505
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 523..535
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 538..540
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 542..554
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 559..561
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 571..579
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 589..598
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 602..604
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 614..623
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 626..637
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 644..650
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 653..658
FT /evidence="ECO:0007829|PDB:4EPA"
FT STRAND 663..671
FT /evidence="ECO:0007829|PDB:4EPA"
SQ SEQUENCE 673 AA; 73782 MW; 9C39E6010EBCEB2C CRC64;
MKMTRLYPLA LGGLLLPAIA NAQTSQQDES TLVVTASKQS SRSASANNVS STVVSAPELS
DAGVTASDKL PRVLPGLNIE NSGNMLFSTI SLRGVSSAQD FYNPAVTLYV DGVPQLSTNT
IQALTDVQSV ELLRGPQGTL YGKSAQGGII NIVTQQPDST PRGYIEGGVS SRDSYRSKFN
LSGPIQDGLL YGSVTLLRQV DDGDMINPAT GSDDLGGTRA SIGNVKLRLA PDDQPWEMGF
AASRECTRAT QDAYVGWNDI KGRKLSISDG SPDPYMRRCT DSQTLSGKYT TDDWVFNLIS
AWQQQHYSRT FPSGSLIVNM PQRWNQDVQE LRAATLGDAR TVDMVFGLYR QNTREKLNSA
YDMPTMPYLS STGYTTAETL AAYSDLTWHL TDRFDIGGGV RFSHDKSSTQ YHGSMLGNPF
GDQGKSNDDQ VLGQLSAGYM LTDDWRVYTR VAQGYKPSGY NIVPTAGLDA KPFVAEKSIN
YELGTRYETA DVTLQAATFY THTKDMQLYS GPVRMQTLSN AGKADATGVE LEAKWRFAPG
WSWDINGNVI RSEFTNDSEL YHGNRVPFVP RYGAGSSVNG VIDTRYGALM PRLAVNLVGP
HYFDGDNQLR QGTYATLDSS LGWQATERMN ISVYVDNLFD RRYRTYGYMN GSSAVAQVNM
GRTVGINTRI DFF
