ID   FYV10_COCIM             Reviewed;         402 AA.
AC   Q1DTI6; J3K8K5;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Protein FYV10;
GN   Name=FYV10; ORFNames=CIMG_06377;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Involved in the proteasome-dependent degradation of fructose-
CC       1,6-bisphosphatase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FYV10 family. {ECO:0000305}.
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DR   EMBL; GG704912; EAS30898.3; -; Genomic_DNA.
DR   RefSeq; XP_001242481.1; XM_001242480.2.
DR   AlphaFoldDB; Q1DTI6; -.
DR   SMR; Q1DTI6; -.
DR   STRING; 246410.Q1DTI6; -.
DR   EnsemblFungi; EAS30898; EAS30898; CIMG_06377.
DR   GeneID; 4562443; -.
DR   KEGG; cim:CIMG_06377; -.
DR   VEuPathDB; FungiDB:CIMG_06377; -.
DR   InParanoid; Q1DTI6; -.
DR   OMA; DVKYDEW; -.
DR   OrthoDB; 1087488at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0045721; P:negative regulation of gluconeogenesis; IEA:UniProt.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   InterPro; IPR013144; CRA_dom.
DR   InterPro; IPR024964; CTLH/CRA.
DR   InterPro; IPR006595; CTLH_C.
DR   InterPro; IPR027714; Fyv10/MAEA.
DR   InterPro; IPR045098; Fyv10_fam.
DR   InterPro; IPR006594; LisH.
DR   InterPro; IPR044063; ZF_RING_GID.
DR   PANTHER; PTHR12170; PTHR12170; 1.
DR   PANTHER; PTHR12170:SF2; PTHR12170:SF2; 1.
DR   Pfam; PF10607; CLTH; 1.
DR   SMART; SM00757; CRA; 1.
DR   SMART; SM00668; CTLH; 1.
DR   PROSITE; PS50897; CTLH; 1.
DR   PROSITE; PS50896; LISH; 1.
DR   PROSITE; PS51867; ZF_RING_GID; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..402
FT                   /note="Protein FYV10"
FT                   /id="PRO_0000292457"
FT   DOMAIN          126..158
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   DOMAIN          164..221
FT                   /note="CTLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00058"
FT   ZN_FING         326..387
FT                   /note="RING-Gid-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01215"
SQ   SEQUENCE   402 AA;  45626 MW;  C01918F2574D9D86 CRC64;
     MAVELTSIKL NPENHLLLDQ PLLRVPHELA RRNFKSVQRI VEREKDYVLP ALKETANASL
     SGSKNPTETI EALDAMITRM QGLKRKMEVL HEEEKKIATQ SQKRIQYIQD LYKIPSLADV
     KYEQWSRTRL NRLLADHMLR SGYLESAKQL AEDKGIADLV DLSVFAQCQR IAHSLRRGET
     KEALQWCGEN KVALKKIQNR LEFELRLQQY IEVLRVGDKA EARQHAKKFL TPHSETQSHD
     IQRAAGLLAY PPDTRAEPYM SMYSLERWKH LSDLFIRTHH DLLSLSSRPL LQIALSAGLS
     ALKTPSCHSA IASSRASPLS LSTSICPICS TELNELARHV PYAHHTKSSV ENDPVVLPNR
     RVYGMDRLSD MSKKAGVPEG KVKDPITGEI FDVSEVKKVY IS