ID   FYV10_KLULA             Reviewed;         468 AA.
AC   Q6CP05;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Protein FYV10;
GN   Name=FYV10; OrderedLocusNames=KLLA0E08503g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in the proteasome-dependent degradation of fructose-
CC       1,6-bisphosphatase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FYV10 family. {ECO:0000305}.
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DR   EMBL; CR382125; CAG99421.1; -; Genomic_DNA.
DR   RefSeq; XP_454334.1; XM_454334.1.
DR   AlphaFoldDB; Q6CP05; -.
DR   SMR; Q6CP05; -.
DR   STRING; 28985.XP_454334.1; -.
DR   EnsemblFungi; CAG99421; CAG99421; KLLA0_E08537g.
DR   GeneID; 2893637; -.
DR   KEGG; kla:KLLA0_E08537g; -.
DR   eggNOG; KOG0396; Eukaryota.
DR   HOGENOM; CLU_027445_2_0_1; -.
DR   InParanoid; Q6CP05; -.
DR   OMA; DVKYDEW; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0034657; C:GID complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:EnsemblFungi.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:EnsemblFungi.
DR   GO; GO:0045721; P:negative regulation of gluconeogenesis; IEA:EnsemblFungi.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
DR   InterPro; IPR024964; CTLH/CRA.
DR   InterPro; IPR006595; CTLH_C.
DR   InterPro; IPR027714; Fyv10/MAEA.
DR   InterPro; IPR045098; Fyv10_fam.
DR   InterPro; IPR044063; ZF_RING_GID.
DR   PANTHER; PTHR12170; PTHR12170; 1.
DR   PANTHER; PTHR12170:SF2; PTHR12170:SF2; 1.
DR   Pfam; PF10607; CLTH; 1.
DR   SMART; SM00668; CTLH; 1.
DR   PROSITE; PS50897; CTLH; 1.
DR   PROSITE; PS51867; ZF_RING_GID; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..468
FT                   /note="Protein FYV10"
FT                   /id="PRO_0000292460"
FT   DOMAIN          171..229
FT                   /note="CTLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00058"
FT   ZN_FING         386..453
FT                   /note="RING-Gid-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01215"
SQ   SEQUENCE   468 AA;  54712 MW;  4FDA1A14402D1B94 CRC64;
     MTSLNEPNVD FHLKLNQQQF NIPSELLKRN WDKFNNLYTS YSVELQGQFA TLNTLLEDPN
     KDEQSIEKLN DIINTVNILQ KRLSQLHDNE LTILERIEKR VEYFKQFERF KYDSNTDKLL
     KWYRSYTDLL IADYLVRHGS NSIDHKNKIA SNSGIEFIKT RGLEDLIDYE VLIEANQISM
     ELIENKNLRP LLEWIENNSA HLTEKGSHLQ FQALLQEYIE LVRCSDYKAA IRCFQTHLAH
     FANIYPKELK LAAGILAFFK SCLNNGRDDE VTNEQKLFHA YFRKQMYRPH PLSSISSSNV
     VHNAELCRYG PLLDHERWES LNKMFLHEFY SLYKISYHDP LLIYISLGIS SLKTKDCGHT
     ISAQLIPHEN PEVNEYIKSN VVNTDCPVCN HDIFPLSENL PFAHHIQSSL FENPVMLPNG
     NIYDSEKLIS LSRKLNKMGY TKLKENQVMD PIDKSIYATT DFIKMYPT