ID   FYV10_PICST             Reviewed;         511 AA.
AC   A3LPW2;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Protein FYV10;
GN   Name=FYV10; ORFNames=PICST_55076;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Involved in the proteasome-dependent degradation of fructose-
CC       1,6-bisphosphatase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FYV10 family. {ECO:0000305}.
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DR   EMBL; CP000496; ABN64567.2; -; Genomic_DNA.
DR   RefSeq; XP_001382596.2; XM_001382559.1.
DR   AlphaFoldDB; A3LPW2; -.
DR   SMR; A3LPW2; -.
DR   STRING; 4924.XP_001382596.2; -.
DR   EnsemblFungi; ABN64567; ABN64567; PICST_55076.
DR   GeneID; 4837192; -.
DR   KEGG; pic:PICST_55076; -.
DR   eggNOG; KOG0396; Eukaryota.
DR   HOGENOM; CLU_027445_2_0_1; -.
DR   InParanoid; A3LPW2; -.
DR   OMA; IKLEMIR; -.
DR   OrthoDB; 1087488at2759; -.
DR   Proteomes; UP000002258; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0045721; P:negative regulation of gluconeogenesis; IEA:UniProt.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   InterPro; IPR013144; CRA_dom.
DR   InterPro; IPR024964; CTLH/CRA.
DR   InterPro; IPR006595; CTLH_C.
DR   InterPro; IPR027714; Fyv10/MAEA.
DR   InterPro; IPR045098; Fyv10_fam.
DR   InterPro; IPR044063; ZF_RING_GID.
DR   PANTHER; PTHR12170; PTHR12170; 1.
DR   PANTHER; PTHR12170:SF2; PTHR12170:SF2; 1.
DR   Pfam; PF10607; CLTH; 1.
DR   SMART; SM00757; CRA; 1.
DR   PROSITE; PS50897; CTLH; 1.
DR   PROSITE; PS51867; ZF_RING_GID; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..511
FT                   /note="Protein FYV10"
FT                   /id="PRO_0000292465"
FT   DOMAIN          201..259
FT                   /note="CTLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00058"
FT   ZN_FING         430..496
FT                   /note="RING-Gid-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01215"
FT   REGION          112..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..142
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   511 AA;  59773 MW;  D17EC24D0EC641AA CRC64;
     MSEPSLNFHI QSHSTQFRIP TELIKKNFKT IQKLVEKQKK QMTDDVAKIK KNPNIPTAMK
     LAMVRKSIKS FEGFQKKLQA SIAKDEELRS RLIARIEHLA LISEYCITQD KTKTQVEKPS
     QPQSQNEDTE EKEHSTKDDN DKYLDLHNPN LITWYRDQTN LLIIDYLIKS NTRTDHNIGL
     LLLKSLSESN PKYMKLIDYD LFESFNKVYV SIMEDHDLTL VIAWFNENRN FLKKANSNLE
     FEINYCRFLS LIEKGDVNEA IKFSSINLSP YGNVSNYQDT DRANHEHNLN RLKEIGGLLV
     YMAINEEKRT RNDKIAFSSN LLINSPRFHE YEKLLSDERW DSLSMCFVEN FTKLYGISKN
     YPIFIYLSAG LASLKTKSCY HNTENTIFRE NQEINVTDES IYKKDLTVLT DKKYRGSNQY
     YKLLNKINNC PVCSPELYKL SRNLPYAQLI TSIFNNPFKL PNGNIYPFDK LLNPSEKYLS
     EKNTLLRMGK IKDPLTREIF LIDTCIRVYP A