FYV5_YEAST
ID FYV5_YEAST Reviewed; 152 AA.
AC P25585; D6VQU8;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Protein FYV5;
DE AltName: Full=Function required for yeast viability protein 5;
GN Name=FYV5; OrderedLocusNames=YCL058C; ORFNames=YCL58C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=1574125; DOI=10.1038/357038a0;
RA Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA Sgouros J.G.;
RT "The complete DNA sequence of yeast chromosome III.";
RL Nature 357:38-46(1992).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP FUNCTION.
RX PubMed=10234789;
RX DOI=10.1002/(sici)1097-0061(199904)15:6<513::aid-yea370>3.0.co;2-p;
RA Bianchi M.M., Sartori G., Vandenbol M., Kaniak A., Uccelletti D.,
RA Mazzoni C., Di Rago J.-P., Carignani G., Slonimski P.P., Frontali L.;
RT "How to bring orphan genes into functional families.";
RL Yeast 15:513-526(1999).
RN [5]
RP FUNCTION.
RX PubMed=12829295; DOI=10.1016/s0378-1097(03)00384-7;
RA Zettel M.F., Garza L.R., Cass A.M., Myhre R.A., Haizlip L.A., Osadebe S.N.,
RA Sudimack D.W., Pathak R., Stone T.L., Polymenis M.;
RT "The budding index of Saccharomyces cerevisiae deletion strains identifies
RT genes important for cell cycle progression.";
RL FEMS Microbiol. Lett. 223:253-258(2003).
RN [6]
RP FUNCTION [LARGE SCALE ANALYSIS].
RX PubMed=12663529; DOI=10.1093/genetics/163.3.875;
RA Page N., Gerard-Vincent M., Menard P., Beaulieu M., Azuma M.,
RA Dijkgraaf G.J.P., Li H., Marcoux J., Nguyen T., Dowse T., Sdicu A.-M.,
RA Bussey H.;
RT "A Saccharomyces cerevisiae genome-wide mutant screen for altered
RT sensitivity to K1 killer toxin.";
RL Genetics 163:875-894(2003).
RN [7]
RP FUNCTION.
RX PubMed=16251355; DOI=10.1091/mbc.e05-06-0520;
RA Rand J.D., Grant C.M.;
RT "The thioredoxin system protects ribosomes against stress-induced
RT aggregation.";
RL Mol. Biol. Cell 17:387-401(2006).
CC -!- FUNCTION: Involved in maintaining an adequate ionic strength
CC homeostasis of the cellular aqueous environment, necessary for normal
CC growth rate. Required for survival upon exposure to K1 killer toxin and
CC hence plays a role in cell wall glucan synthesis. Required for
CC dithiothreitol (DTT) resistance. Involved in cell cycle progression.
CC {ECO:0000269|PubMed:10234789, ECO:0000269|PubMed:12663529,
CC ECO:0000269|PubMed:12829295, ECO:0000269|PubMed:16251355}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Secreted, cell wall.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X59720; CAA42387.1; -; Genomic_DNA.
DR EMBL; AY558144; AAS56470.1; -; Genomic_DNA.
DR EMBL; BK006937; DAA33856.1; -; Genomic_DNA.
DR PIR; S19388; S19388.
DR RefSeq; NP_009873.1; NM_001178702.1.
DR AlphaFoldDB; P25585; -.
DR BioGRID; 300332; 4.
DR DIP; DIP-4982N; -.
DR IntAct; P25585; 1.
DR STRING; 4932.YCL058C; -.
DR PaxDb; P25585; -.
DR EnsemblFungi; YCL058C_mRNA; YCL058C; YCL058C.
DR GeneID; 850299; -.
DR KEGG; sce:YCL058C; -.
DR SGD; S000000563; FYV5.
DR VEuPathDB; FungiDB:YCL058C; -.
DR HOGENOM; CLU_1723392_0_0_1; -.
DR BioCyc; YEAST:G3O-29309-MON; -.
DR PRO; PR:P25585; -.
DR Proteomes; UP000002311; Chromosome III.
DR RNAct; P25585; protein.
DR GO; GO:0005829; C:cytosol; HDA:SGD.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0006873; P:cellular ion homeostasis; IMP:SGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:SGD.
DR GO; GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IMP:SGD.
PE 4: Predicted;
KW Cell cycle; Cell membrane; Cell wall; Cell wall biogenesis/degradation;
KW Membrane; Reference proteome; Secreted; Transmembrane; Transmembrane helix.
FT CHAIN 1..152
FT /note="Protein FYV5"
FT /id="PRO_0000202552"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 152 AA; 17139 MW; 4FC9AF3266FB9DF7 CRC64;
MQYHSALYVY IYVTFTTIPY KEKPDIISIC FSMLSFVFDF SVRICSRTLE SFSWSLISSS
AFKVVSAFSL AGSCVLASRS SVGIIVSLLL FNFSTCNFVL FLSAVLIDLF FCTFLPTPTF
LPTPFFFMLH LPIFSLLNAL ELLYLIIAGL HI
