ID   FYV6_KLULA              Reviewed;         164 AA.
AC   Q6CIS0;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Protein FYV6;
GN   Name=FYV6; OrderedLocusNames=KLLA0F24442g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in telomere length regulation and promotes fully
CC       efficient non-homologous end-joining (NHEJ) by a mechanism activated in
CC       postdiauxic/stationary phase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FYV6 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98877.1; -; Genomic_DNA.
DR   RefSeq; XP_456169.1; XM_456169.1.
DR   AlphaFoldDB; Q6CIS0; -.
DR   SMR; Q6CIS0; -.
DR   EnsemblFungi; CAG98877; CAG98877; KLLA0_F24442g.
DR   GeneID; 2895226; -.
DR   KEGG; kla:KLLA0_F24442g; -.
DR   HOGENOM; CLU_1619291_0_0_1; -.
DR   InParanoid; Q6CIS0; -.
DR   OMA; HESGRPE; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019331; FAM192A/Fyv6_N.
DR   Pfam; PF10187; FAM192A_Fyv6_N; 1.
PE   3: Inferred from homology;
KW   Chromosome; Nucleus; Reference proteome; Telomere.
FT   CHAIN           1..164
FT                   /note="Protein FYV6"
FT                   /id="PRO_0000292478"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          95..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..72
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..127
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   164 AA;  19084 MW;  372323A8D1E1418F CRC64;
     MADNPKAPTF IKEGSGDLES QRRNEQVNRE VGELVTRKSL SDQLRENSKK KRQQFQRQTK
     EKNSFTRVSN DDLDHINKVK LDELEKLRNF SQWAESEERN RRKQLQLLQQ PSTPEHTNKQ
     VISKNDPIPT SIKVRKLKTS NGAKNALGVI SKPKHKKTDR TQKK