ID   FYV8_KLULA              Reviewed;         806 AA.
AC   Q6CRE9;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Protein FYV8;
GN   Name=FYV8; OrderedLocusNames=KLLA0D09603g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in the resistance to unfolded protein response
CC       (UPR)-inducing agents. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FYV8 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH00586.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR382124; CAH00586.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_453490.1; XM_453490.1.
DR   AlphaFoldDB; Q6CRE9; -.
DR   STRING; 28985.XP_453490.1; -.
DR   EnsemblFungi; CAH00586; CAH00586; KLLA0_D09603g.
DR   GeneID; 2892908; -.
DR   KEGG; kla:KLLA0_D09603g; -.
DR   eggNOG; ENOG502QPM9; Eukaryota.
DR   HOGENOM; CLU_009686_0_0_1; -.
DR   InParanoid; Q6CRE9; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   InterPro; IPR026248; Fyv8.
DR   PRINTS; PR02076; PROTEINFYV8.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..806
FT                   /note="Protein FYV8"
FT                   /id="PRO_0000292481"
FT   REGION          1..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          101..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          248..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          409..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..88
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..307
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..346
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        442..459
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        460..504
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   806 AA;  88476 MW;  EA954ECC7C0116FB CRC64;
     MSDNITRHKS QRWVSASKAN YDGADWDAYS SNSEDEGLTN NIPQLPQVNI PESNNIAKSS
     SPDPSIGTCL RSDSLNTSVR SGNKSVNDDL DSLMHQISQE MTAKDEDVNN TSDPEDEDDA
     ELKVSKTGYF AAYVNDEDTD DRESVKSDIE SAKLAESATE INKTDNAKAE SVSEVESVAE
     SVKRAKVEVE PVQIVNVGEE SFKGDDSEAE SVKRADVEVE PFKIVSAEEE PLKGDDTEVE
     LFKNAASEVE TSQISVELQD EMIDPTTEIP SRIQGDVAIS DDKGSKDAVD EDNWSKSDSH
     PESIGSQDKE EMPPSSINSL PSESQLSIQH SKEGDSNDSD SLLNGYGSEP SLMKDNASPV
     KLRKTSKTDL SYHDGYSSES SGEEKERAIS EVSLGQYVVH SAESFKFRNP VRNSVLDSSD
     DDIDYTDEDG DLEVTKSGYF AAMVDEDKEI DDSDRHTLNN NDTDGLTADS DVNSITESVT
     KRLSQSSITQ SDVPDQNSEN DVGGYSDSSE DEEDGPQKLA FSTRESINLG KWKPDTDAFR
     SGFVTETIDI NNPPEGYTVN EDGEIVEVNK NTTSNIQRNS SVASDGESQF NAFPHDVASD
     DDDLKTIADT KTIYDNQTIY NVPALIANNA SAPALPTNIQ ITNESTDYVS SNDTIFKHVN
     GEAPKGESKL KEAFSSEGDE IPSVVHQSTV PNLDLVKLLS SNELHSQKLK KLNNYKEQLK
     EYDSGLQSWI QYALKSSTTS DKDFIFKDYK VNKHVQDAYA QADILSKKNS VANTVNQNVT
     HLKKKMFSSS MREKSKGLFS SIGKKL