ID   FYWP_LACLM              Reviewed;         457 AA.
AC   A2RMP5;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Aromatic amino acid permease FywP {ECO:0000305};
GN   Name=fywP {ECO:0000303|PubMed:23144255};
GN   OrderedLocusNames=llmg_2011 {ECO:0000312|EMBL:CAL98579.1};
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=MG1363;
RX   PubMed=23144255; DOI=10.1128/jb.01948-12;
RA   Trip H., Mulder N.L., Lolkema J.S.;
RT   "Cloning, expression, and functional characterization of secondary amino
RT   acid transporters of Lactococcus lactis.";
RL   J. Bacteriol. 195:340-350(2013).
CC   -!- FUNCTION: Involved in phenylalanine and tyrosine uptake. Has also
CC       affinity for tryptophan. Plays no significant role in the excretion of
CC       accumulated phenylalanine. {ECO:0000269|PubMed:23144255}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of the gene reduces the efficiency of
CC       growth at low concentrations of the aromatic amino acids.
CC       {ECO:0000269|PubMed:23144255}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
CC       {ECO:0000305}.
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DR   EMBL; AM406671; CAL98579.1; -; Genomic_DNA.
DR   RefSeq; WP_011835738.1; NZ_WJVF01000004.1.
DR   AlphaFoldDB; A2RMP5; -.
DR   SMR; A2RMP5; -.
DR   STRING; 416870.llmg_2011; -.
DR   EnsemblBacteria; CAL98579; CAL98579; llmg_2011.
DR   KEGG; llm:llmg_2011; -.
DR   eggNOG; COG1113; Bacteria.
DR   HOGENOM; CLU_007946_9_3_9; -.
DR   OMA; PKFLDYV; -.
DR   PhylomeDB; A2RMP5; -.
DR   BioCyc; LLAC416870:LLMG_RS10065-MON; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   Pfam; PF00324; AA_permease; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..457
FT                   /note="Aromatic amino acid permease FywP"
FT                   /id="PRO_0000442539"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   457 AA;  49432 MW;  A930040BF887FF0B CRC64;
     MENSTGLKSS LKTRHIVMLS LGGAIGSGLF LGSGKVIAQA GPSVLLSYVL AGLTLYVVMY
     GVGKMVIHQD DHKAGMAGVV APFIGDHWAH FADWVYWATW MAVLIAEEAG VSTFLAILIP
     GVPLWVFALV VAVLGTAINL WSVKAFAETE YWLAFIKVAV ILLLIALGIY LLVINDAHLG
     FVADSAQKVT TKSTAPSFAP NGFSGFLTSL LVVIFSFGGS ELAAITVAET ENPKVAIPRA
     IRGVLIRIIS FYVIPIFLFL HLLPWSEVSN PDAASPFATI FARVGIPHAD KIVLVIIVIA
     IFSAVNSAIY ATSRSLYSRI QGSSTYVGKK LGKLSKNQVP TNAILVSSFV LFIGVLLSAV
     LGDGFWQFVA GSISFTISIV WILLLVAALV LYFKHKEVTN WFVKLATLVV LIALSLVFIM
     QIITNPWTLS VFALVICLLS YFSYRKKKSI IEKTFIL