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FZD2_CHICK
ID   FZD2_CHICK              Reviewed;         523 AA.
AC   Q9IA06; Q9PTW4;
DT   05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Frizzled-2;
DE            Short=Fz-2;
DE            Short=cFz-2;
DE   Flags: Fragment;
GN   Name=FZD2; Synonyms=FZ2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10781956; DOI=10.1016/s0925-4773(00)00263-x;
RA   Stark M.R., Biggs J.J., Schoenwolf G.C., Rao M.S.;
RT   "Characterization of avian frizzled genes in cranial placode development.";
RL   Mech. Dev. 93:195-200(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 233-315.
RC   TISSUE=Limb bud;
RX   PubMed=10512196;
RA   Nohno T., Kawakami Y., Wada N., Komaguchi C., Nishimatsu S.;
RT   "Differential expression of the frizzled family involved in Wnt signaling
RT   during chick limb development.";
RL   Cell. Mol. Biol. 45:653-659(1999).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=25759469; DOI=10.1093/hmg/ddv088;
RA   Saal H.M., Prows C.A., Guerreiro I., Donlin M., Knudson L., Sund K.L.,
RA   Chang C.F., Brugmann S.A., Stottmann R.W.;
RT   "A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal
RT   dominant omodysplasia.";
RL   Hum. Mol. Genet. 24:3399-3409(2015).
CC   -!- FUNCTION: Receptor for Wnt proteins. Most of frizzled receptors are
CC       coupled to the beta-catenin canonical signaling pathway, which leads to
CC       the activation of disheveled proteins, inhibition of GSK-3 kinase,
CC       nuclear accumulation of beta-catenin and activation of Wnt target genes
CC       (By similarity). A second signaling pathway involving PKC and calcium
CC       fluxes has been seen for some family members, but it is not yet clear
CC       if it represents a distinct pathway or if it can be integrated in the
CC       canonical pathway, as PKC seems to be required for Wnt-mediated
CC       inactivation of GSK-3 kinase. Both pathways seem to involve
CC       interactions with G-proteins. May be involved in transduction and
CC       intercellular transmission of polarity information during tissue
CC       morphogenesis and/or in differentiated tissues.
CC       {ECO:0000250|UniProtKB:Q14332}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell
CC       membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the developing head and limbs
CC       (PubMed:25759469). Expressed broadly in cranial ectoderm. Also
CC       expressed in the developing somites (dermomyotome) and in other cranial
CC       placodes, including the olfactory, lens, and otic placodes (rostral rim
CC       of the vesicle). {ECO:0000269|PubMed:25759469}.
CC   -!- DEVELOPMENTAL STAGE: At stage 8, faintly expressed in cranial ectoderm
CC       and in the somites. At stages 9-10, broadly expressed throughout the
CC       cranial ectoderm. By stages 11-12, more robust expression is detected
CC       in ectoderm adjacent to the hindbrain, including the otic placodes.
CC       Transiently expressed in the lens placode and ectoderm of the head at
CC       stages 13-15. Down-regulated in differentiating structures of older
CC       embryos.
CC   -!- DOMAIN: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl
CC       (Disheveled) family members and is involved in the activation of the
CC       Wnt/beta-catenin signaling pathway. {ECO:0000250}.
CC   -!- DOMAIN: The FZ domain is involved in binding with Wnt ligands.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC       {ECO:0000305}.
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DR   EMBL; AF224315; AAF61095.1; -; mRNA.
DR   EMBL; AB029449; BAA89399.1; -; mRNA.
DR   AlphaFoldDB; Q9IA06; -.
DR   SMR; Q9IA06; -.
DR   STRING; 9031.ENSGALP00000034947; -.
DR   PaxDb; Q9IA06; -.
DR   VEuPathDB; HostDB:geneid_374061; -.
DR   eggNOG; KOG3577; Eukaryota.
DR   InParanoid; Q9IA06; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0042813; F:Wnt receptor activity; IBA:GO_Central.
DR   GO; GO:0017147; F:Wnt-protein binding; IBA:GO_Central.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR   CDD; cd07464; CRD_FZ2; 1.
DR   Gene3D; 1.10.2000.10; -; 1.
DR   InterPro; IPR015526; Frizzled/SFRP.
DR   InterPro; IPR000539; Frizzled/Smoothened_TM.
DR   InterPro; IPR020067; Frizzled_dom.
DR   InterPro; IPR036790; Frizzled_dom_sf.
DR   InterPro; IPR041778; FZ2_CRD.
DR   InterPro; IPR026550; FZD1/2.
DR   InterPro; IPR017981; GPCR_2-like.
DR   PANTHER; PTHR11309; PTHR11309; 1.
DR   PANTHER; PTHR11309:SF34; PTHR11309:SF34; 1.
DR   Pfam; PF01534; Frizzled; 1.
DR   Pfam; PF01392; Fz; 1.
DR   PRINTS; PR00489; FRIZZLED.
DR   SMART; SM00063; FRI; 1.
DR   SMART; SM01330; Frizzled; 1.
DR   SUPFAM; SSF63501; SSF63501; 1.
DR   PROSITE; PS50038; FZ; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Developmental protein; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix;
KW   Wnt signaling pathway.
FT   CHAIN           <1..523
FT                   /note="Frizzled-2"
FT                   /id="PRO_0000205975"
FT   TOPO_DOM        1..205
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        227..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..285
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        307..328
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..349
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        350..372
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        394..419
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..440
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        441..477
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        478..498
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        499..523
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..120
FT                   /note="FZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT   MOTIF           501..506
FT                   /note="Lys-Thr-X-X-X-Trp motif, mediates interaction with
FT                   the PDZ domain of Dvl family members"
FT                   /evidence="ECO:0000250"
FT   MOTIF           521..523
FT                   /note="PDZ-binding"
FT   CARBOHYD        20
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        121
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        6..67
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT   DISULFID        14..60
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT   DISULFID        51..88
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT   DISULFID        77..117
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT   DISULFID        81..105
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT   NON_TER         1
SQ   SEQUENCE   523 AA;  59281 MW;  8547F5B018001CB7 CRC64;
     PDHGFCQPIS IPLCTDIAYN QTIMPNLLGH TNQEDAGLEV HQFYPLVKVQ CSLELKFFLC
     SMYAPVCTVL EQAIPPCRSI CERARQGCEA LMNKFGFQWP ERLRCENFPR HGAEQICVGQ
     NHSEDGGSSA ALLTSAAPPA AHGTPGAPRY ATPDRPFHCP RALKVPGYLN YKFLGEKDCA
     APCEPSRPDG HMFFNEDEIR FARVWILVWS VLCCASTFFT VTTYLVDMQR FRYPERPIIF
     LSGCYTMVSV AYIAGFVLEE RVVCNERFQE DGYRTVVQGT KKEGCTILFM MLYFFSMASS
     IWWVILSLTW FLAAGMKWGH EAIEANSQYF HLAAWAVPAV KTITILAMGQ IDGDLLSGVC
     FVGLNGIDPL RGFVLAPLFV YLFIGTSFLL AGFVSLFRIR TIMKHGGTKT EKLERLMVRI
     GVFSVLYTVP ATIVIACYFY EQAFRQHWER SWISQHCKSL AIPCPLHFTP RMTPDFTVYM
     IKYLMTLIVG ITSGFWIFSG KTLHSWRKFY TRLTNSRQGE TTV
 
 
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