ID   FZD3_CHICK              Reviewed;          76 AA.
AC   Q9PTW3;
DT   05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Frizzled-3;
DE            Short=Fz-3;
DE            Short=cFz-3;
DE   Flags: Fragment;
GN   Name=FZD3; Synonyms=FZ3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Limb bud;
RX   PubMed=10512196;
RA   Nohno T., Kawakami Y., Wada N., Komaguchi C., Nishimatsu S.;
RT   "Differential expression of the frizzled family involved in Wnt signaling
RT   during chick limb development.";
RL   Cell. Mol. Biol. 45:653-659(1999).
CC   -!- FUNCTION: Receptor for Wnt proteins. Most of frizzled receptors are
CC       coupled to the beta-catenin canonical signaling pathway, which leads to
CC       the activation of disheveled proteins, inhibition of GSK-3 kinase,
CC       nuclear accumulation of beta-catenin and activation of Wnt target
CC       genes. A second signaling pathway involving PKC and calcium fluxes has
CC       been seen for some family members, but it is not yet clear if it
CC       represents a distinct pathway or if it can be integrated in the
CC       canonical pathway, as PKC seems to be required for Wnt-mediated
CC       inactivation of GSK-3 kinase. Both pathways seem to involve
CC       interactions with G-proteins. May be involved in transduction and
CC       intercellular transmission of polarity information during tissue
CC       morphogenesis and/or in differentiated tissues. Plays a role in
CC       controlling early axon growth and guidance processes necessary for the
CC       formation of a subset of central and peripheral major fiber tracts.
CC       Involved in the migration of cranial neural crest cells. May also be
CC       implicated in the transmission of sensory information from the trunk
CC       and limbs to the brain. Controls commissural sensory axons guidance
CC       after midline crossing along the anterior-posterior axis in the
CC       developing spinal cord in a Wnt-dependent signaling pathway. Together
CC       with FZD6, is involved in the neural tube closure and plays a role in
CC       the regulation of the establishment of planar cell polarity (PCP).
CC       Promotes neurogenesis by maintaining sympathetic neuroblasts within the
CC       cell cycle in a beta-catenin-dependent manner (By similarity).
CC       {ECO:0000250|UniProtKB:Q61086}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell
CC       membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell
CC       surface {ECO:0000250|UniProtKB:Q61086}. Apical cell membrane
CC       {ECO:0000250|UniProtKB:Q61086}; Multi-pass membrane protein
CC       {ECO:0000250}.
CC   -!- DOMAIN: The FZ domain is involved in binding with Wnt ligands.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC       {ECO:0000305}.
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DR   EMBL; AB029450; BAA89400.1; -; mRNA.
DR   AlphaFoldDB; Q9PTW3; -.
DR   SMR; Q9PTW3; -.
DR   STRING; 9031.ENSGALP00000026786; -.
DR   PaxDb; Q9PTW3; -.
DR   VEuPathDB; HostDB:geneid_395572; -.
DR   eggNOG; KOG3577; Eukaryota.
DR   InParanoid; Q9PTW3; -.
DR   PhylomeDB; Q9PTW3; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0042813; F:Wnt receptor activity; IBA:GO_Central.
DR   GO; GO:0017147; F:Wnt-protein binding; IBA:GO_Central.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   InterPro; IPR015526; Frizzled/SFRP.
DR   InterPro; IPR000539; Frizzled/Smoothened_TM.
DR   InterPro; IPR026553; FZD3_vertebrates.
DR   InterPro; IPR017981; GPCR_2-like.
DR   PANTHER; PTHR11309; PTHR11309; 1.
DR   PANTHER; PTHR11309:SF22; PTHR11309:SF22; 1.
DR   Pfam; PF01534; Frizzled; 1.
DR   PRINTS; PR00489; FRIZZLED.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Developmental protein; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Neurogenesis; Receptor; Reference proteome;
KW   Transducer; Transmembrane; Transmembrane helix; Wnt signaling pathway.
FT   CHAIN           <1..>76
FT                   /note="Frizzled-3"
FT                   /id="PRO_0000205976"
FT   TOPO_DOM        <1..5
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        6..26
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        27..54
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..>76
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         76
SQ   SEQUENCE   76 AA;  8747 MW;  189CB4786B3E2363 CRC64;
     YPERPIIFYA VCYMMVSLIF FIGFLLEDRV ACNASSPAQY KASTVTQGSH NKACTMLFMV
     LYFFTMAGSV WWVILR