FZD6_CHICK
ID FZD6_CHICK Reviewed; 190 AA.
AC Q9PTW1;
DT 05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Frizzled-6;
DE Short=Fz-6;
DE Short=cFz-6;
DE Flags: Fragment;
GN Name=FZD6; Synonyms=FZ6;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Limb bud;
RX PubMed=10512196;
RA Nohno T., Kawakami Y., Wada N., Komaguchi C., Nishimatsu S.;
RT "Differential expression of the frizzled family involved in Wnt signaling
RT during chick limb development.";
RL Cell. Mol. Biol. 45:653-659(1999).
CC -!- FUNCTION: Receptor for Wnt proteins. Most of frizzled receptors are
CC coupled to the beta-catenin canonical signaling pathway, which leads to
CC the activation of disheveled proteins, inhibition of GSK-3 kinase,
CC nuclear accumulation of beta-catenin and activation of Wnt target
CC genes. A second signaling pathway involving PKC and calcium fluxes has
CC been seen for some family members, but it is not yet clear if it
CC represents a distinct pathway or if it can be integrated in the
CC canonical pathway, as PKC seems to be required for Wnt-mediated
CC inactivation of GSK-3 kinase. Both pathways seem to involve
CC interactions with G-proteins. Activation by Wnt5A stimulates PKC
CC activity via a G-protein-dependent mechanism. Involved in transduction
CC and intercellular transmission of polarity information during tissue
CC morphogenesis and/or in differentiated tissues. Together with FZD3, may
CC be involved in the neural tube closure and plays a role in the
CC regulation of the establishment of planar cell polarity (PCP),
CC particularly in the orientation of asymmetric bundles of stereocilia on
CC the apical faces of a subset of auditory and vestibular sensory cells
CC located in the inner ear (By similarity).
CC {ECO:0000250|UniProtKB:Q61089}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q61089}; Multi-
CC pass membrane protein {ECO:0000255}. Cell membrane
CC {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein
CC {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:Q61089}. Apical cell
CC membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein
CC {ECO:0000255}. Cytoplasmic vesicle membrane
CC {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- DOMAIN: The FZ domain is involved in binding with Wnt ligands.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
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DR EMBL; AB029452; BAA89402.1; -; mRNA.
DR RefSeq; NP_001258860.1; NM_001271931.2.
DR AlphaFoldDB; Q9PTW1; -.
DR SMR; Q9PTW1; -.
DR STRING; 9031.ENSGALP00000025843; -.
DR PaxDb; Q9PTW1; -.
DR GeneID; 378788; -.
DR KEGG; gga:378788; -.
DR CTD; 8323; -.
DR VEuPathDB; HostDB:geneid_378788; -.
DR eggNOG; KOG3577; Eukaryota.
DR InParanoid; Q9PTW1; -.
DR OrthoDB; 330751at2759; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0042813; F:Wnt receptor activity; IBA:GO_Central.
DR GO; GO:0017147; F:Wnt-protein binding; IBA:GO_Central.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_TM.
DR InterPro; IPR026543; FZD6.
DR InterPro; IPR017981; GPCR_2-like.
DR PANTHER; PTHR11309; PTHR11309; 1.
DR PANTHER; PTHR11309:SF75; PTHR11309:SF75; 1.
DR Pfam; PF01534; Frizzled; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM01330; Frizzled; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytoplasmic vesicle; Developmental protein;
KW G-protein coupled receptor; Glycoprotein; Membrane; Neurogenesis; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix;
KW Wnt signaling pathway.
FT CHAIN <1..>190
FT /note="Frizzled-6"
FT /id="PRO_0000205977"
FT TOPO_DOM <1..89
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..121
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143..169
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT DOMAIN <1..20
FT /note="FZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT NON_TER 1
FT NON_TER 190
SQ SEQUENCE 190 AA; 21622 MW; 99C380C7712688D6 CRC64;
FGFAWPEELE CSRLVNCDET APATAPVTTN AHGTQKTPGQ TRRDYGFWCP RHLHTSNGQG
YKFLGIDQCA PPCPNMYFKN YELDVAKSFI GIVSIFCLCA TLFTFLTFLI DVKRFRYPER
PIIYYSVCYS IVSLMYFIGF LLGNRTACNK ADDKLEIGET VVLGSQNKAC TVLFMVLYFF
TMAGTIWWVI
