FZD9_CHICK
ID FZD9_CHICK Reviewed; 392 AA.
AC Q9IA02;
DT 05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Frizzled-9;
DE Short=Fz-9;
DE Short=cFz-9;
DE Flags: Fragment;
GN Name=FZD9; Synonyms=FZ9;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=10781956; DOI=10.1016/s0925-4773(00)00263-x;
RA Stark M.R., Biggs J.J., Schoenwolf G.C., Rao M.S.;
RT "Characterization of avian frizzled genes in cranial placode development.";
RL Mech. Dev. 93:195-200(2000).
CC -!- FUNCTION: Receptor for WNT2 that is coupled to the beta-catenin
CC canonical signaling pathway, which leads to the activation of
CC disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation
CC of beta-catenin and activation of Wnt target genes.
CC {ECO:0000250|UniProtKB:Q8K4C8}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8K4C8};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- DEVELOPMENTAL STAGE: At stages 3-9, expressed in the neural plate/tube.
CC Seen at stages 10-15 in the somites. At stages 15-19, expressed in the
CC dorsal trunk ectoderm and myotome.
CC -!- DOMAIN: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl
CC (Disheveled) family members and is involved in the activation of the
CC Wnt/beta-catenin signaling pathway. {ECO:0000250}.
CC -!- DOMAIN: The FZ domain is involved in binding with Wnt ligands.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
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DR EMBL; AF224319; AAF61099.1; -; mRNA.
DR AlphaFoldDB; Q9IA02; -.
DR SMR; Q9IA02; -.
DR VEuPathDB; HostDB:geneid_373886; -.
DR InParanoid; Q9IA02; -.
DR OrthoDB; 509772at2759; -.
DR PhylomeDB; Q9IA02; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0042813; F:Wnt receptor activity; IBA:GO_Central.
DR GO; GO:0017147; F:Wnt-protein binding; IBA:GO_Central.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_TM.
DR InterPro; IPR017981; GPCR_2-like.
DR PANTHER; PTHR11309; PTHR11309; 1.
DR Pfam; PF01534; Frizzled; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM01330; Frizzled; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Developmental protein; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix; Wnt signaling pathway.
FT CHAIN <1..392
FT /note="Frizzled-9"
FT /id="PRO_0000205979"
FT TOPO_DOM <1..35
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..119
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..161
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..206
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..312
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..392
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOTIF 336..341
FT /note="Lys-Thr-X-X-X-Trp motif, mediates interaction with
FT the PDZ domain of Dvl family members"
FT /evidence="ECO:0000250"
FT MOTIF 390..392
FT /note="PDZ-binding"
FT NON_TER 1
SQ SEQUENCE 392 AA; 43899 MW; 3BCA8E4E4A5ED99A CRC64;
ACDNPEKFQY VEKSLSCAPR CSPGVDVYWS REDKDFAFVW MAVWSTLCFV STAFTVLTFL
LDPHRFQYPE RPIIFLSMCY NVYSVAFIIR SVAGAETIAC DRENGELYII QEGLESTGCT
IVFLILYYFG MASSLWWVVL TLTWFLAAGK KWGHEAIEAH SSYFHMAAWG IPAMKTIVIL
TMRKVAGDEL TGLCYVGSMD VSALTGFVLI PLSCYLVVGT SFILTGFVAL FHIRKIMKTG
GTNTEKLEKL MVKIGVFSIL YTVPATCVIV CYFYERLNVD YWNLRALERA CVPLPGRRAA
DCSLEASVPT VAVFMLKIFM SLVVGITSGV WVWSSKTLQT WQSLCNRKLG VRTRGKPCSG
VSCGGVHCHY KAPTVMLHMT KTDPYLDNPT HV
