FZF1_YEAST
ID FZF1_YEAST Reviewed; 299 AA.
AC P32805; D6VV81; Q2VQB9; Q2VQC2; Q2VQC3;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Zinc finger protein FZF1;
DE AltName: Full=Sulfite resistance protein 1;
GN Name=FZF1; Synonyms=SUL1; OrderedLocusNames=YGL254W; ORFNames=NCR299;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 200060 / W303;
RX PubMed=8322518; DOI=10.1002/yea.320090512;
RA Breitwieser W., Price C., Schuster T.;
RT "Identification of a gene encoding a novel zinc finger protein in
RT Saccharomyces cerevisiae.";
RL Yeast 9:551-556(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7992510; DOI=10.1002/yea.320100812;
RA Casalone E., Colella C.M., Daly S., Fontana S., Torricelli I.,
RA Polsinelli M.;
RT "Cloning and characterization of a sulphite-resistance gene of
RT Saccharomyces cerevisiae.";
RL Yeast 10:1101-1110(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 76625 / YPH499, MMW1-15, MMW1-15h2, MMW1-2, MMW1-2h2, Sgu52E,
RC Sgu52F, YPS396, YPS400, YPS598, YPS600, YPS602, YPS604, YPS606, YPS608, and
RC YPS610;
RX PubMed=16879422; DOI=10.1111/j.1567-1364.2006.00059.x;
RA Aa E., Townsend J.P., Adams R.I., Nielsen K.M., Taylor J.W.;
RT "Population structure and gene evolution in Saccharomyces cerevisiae.";
RL FEMS Yeast Res. 6:702-715(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8972578;
RX DOI=10.1002/(sici)1097-0061(199612)12:15<1555::aid-yea43>3.0.co;2-q;
RA Coissac E., Maillier E., Robineau S., Netter P.;
RT "Sequence of a 39,411 bp DNA fragment covering the left end of chromosome
RT VII of Saccharomyces cerevisiae.";
RL Yeast 12:1555-1562(1996).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [6]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: May function as a transcription factor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 2120 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA47998.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X67787; CAA47998.1; ALT_SEQ; Genomic_DNA.
DR EMBL; X78104; CAA54996.1; -; Genomic_DNA.
DR EMBL; AY949902; AAY27304.1; -; Genomic_DNA.
DR EMBL; AY949903; AAY27305.1; -; Genomic_DNA.
DR EMBL; AY949905; AAY27307.1; -; Genomic_DNA.
DR EMBL; AY949906; AAY27308.1; -; Genomic_DNA.
DR EMBL; AY949908; AAY27310.1; -; Genomic_DNA.
DR EMBL; AY949909; AAY27311.1; -; Genomic_DNA.
DR EMBL; AY949910; AAY27312.1; -; Genomic_DNA.
DR EMBL; AY949911; AAY27313.1; -; Genomic_DNA.
DR EMBL; AY949912; AAY27314.1; -; Genomic_DNA.
DR EMBL; AY949913; AAY27315.1; -; Genomic_DNA.
DR EMBL; AY949914; AAY27316.1; -; Genomic_DNA.
DR EMBL; AY949915; AAY27317.1; -; Genomic_DNA.
DR EMBL; AY949916; AAY27318.1; -; Genomic_DNA.
DR EMBL; AY949917; AAY27319.1; -; Genomic_DNA.
DR EMBL; AY949918; AAY27320.1; -; Genomic_DNA.
DR EMBL; AY949919; AAY27321.1; -; Genomic_DNA.
DR EMBL; X94357; CAA64133.1; -; Genomic_DNA.
DR EMBL; Z72776; CAA96974.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA07865.1; -; Genomic_DNA.
DR PIR; S61607; S61607.
DR RefSeq; NP_011260.1; NM_001181120.1.
DR AlphaFoldDB; P32805; -.
DR SMR; P32805; -.
DR BioGRID; 33025; 104.
DR DIP; DIP-1324N; -.
DR IntAct; P32805; 8.
DR MINT; P32805; -.
DR STRING; 4932.YGL254W; -.
DR MaxQB; P32805; -.
DR PaxDb; P32805; -.
DR PRIDE; P32805; -.
DR EnsemblFungi; YGL254W_mRNA; YGL254W; YGL254W.
DR GeneID; 852638; -.
DR KEGG; sce:YGL254W; -.
DR SGD; S000003223; FZF1.
DR VEuPathDB; FungiDB:YGL254W; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_068955_0_0_1; -.
DR InParanoid; P32805; -.
DR OMA; QHRYSHT; -.
DR BioCyc; YEAST:G3O-30723-MON; -.
DR Reactome; R-SCE-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR PRO; PR:P32805; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P32805; protein.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:SGD.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:SGD.
DR GO; GO:0043565; F:sequence-specific DNA binding; HDA:SGD.
DR GO; GO:0061426; P:positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter; IMP:SGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..299
FT /note="Zinc finger protein FZF1"
FT /id="PRO_0000046805"
FT ZN_FING 12..36
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 42..66
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 72..94
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 155..179
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 246..271
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 191..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 96..107
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 194..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 110
FT /note="G -> E (in strain: Sgu52E and Sgu52F)"
FT VARIANT 120
FT /note="N -> D (in strain: MMW1-15h2, MMW1-2h2, Sgu52E and
FT Sgu52F)"
FT VARIANT 228
FT /note="V -> I (in strain: MMW1-15h2, MMW1-2h2, Sgu52E and
FT Sgu52F)"
FT VARIANT 238
FT /note="D -> N (in strain: MMW1-15h2 and MMW1-2h2)"
FT CONFLICT 180
FT /note="H -> D (in Ref. 2; CAA54996)"
FT /evidence="ECO:0000305"
FT CONFLICT 235
FT /note="T -> W (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 246
FT /note="N -> Y (in Ref. 2; CAA54996)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 299 AA; 33994 MW; A4E7257F012B32FF CRC64;
MTDIGRTKSR NYKCSFDGCE KVYNRPSLLQ QHQNSHTNQK PYHCDEPGCG KKFIRPCHLR
VHKWTHSQIK PKACTLCQKR FVTNQQLRRH LNSHERKSKL ASRIDRKHEG VNANVKAELN
GKEGGFDPKL PSGSPMCGEE FSQGHLPGYD DMQVLQCPYK SCQKVTSFND DLINHMLQHH
IASKLVVPSG DPSLKESLPT SEKSSSTDTT SIPQLSFSTT GTSSSESVDS TTAQTPTDPE
SYWSDNRCKH SDCQELSPFA SVFDLIDHYD HTHAFIPETL VKYSYIHLYK PSVWDLFEY
