ID   FZLC_CAUVN              Reviewed;         576 AA.
AC   A0A0H3C3S1;
DT   12-SEP-2018, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=FtsZ-localized protein C {ECO:0000303|PubMed:20864042};
DE   AltName: Full=FtsZ-binding protein FzlC {ECO:0000305};
GN   Name=fzlC {ECO:0000303|PubMed:20864042};
GN   OrderedLocusNames=CCNA_00099 {ECO:0000312|EMBL:ACL93566.1};
OS   Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=565050;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1000 / CB15N;
RX   PubMed=20472802; DOI=10.1128/jb.00255-10;
RA   Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA   Walunas T.L., Crosson S.;
RT   "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL   J. Bacteriol. 192:3678-3688(2010).
RN   [2]
RP   INTERACTION WITH FTSZ, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=NA1000 / CB15N;
RX   PubMed=20864042; DOI=10.1016/j.molcel.2010.08.027;
RA   Goley E.D., Dye N.A., Werner J.N., Gitai Z., Shapiro L.;
RT   "Imaging-based identification of a critical regulator of FtsZ protofilament
RT   curvature in Caulobacter.";
RL   Mol. Cell 39:975-987(2010).
RN   [3]
RP   FUNCTION, INTERACTION WITH FTSZ, SUBCELLULAR LOCATION, AND DISRUPTION
RP   PHENOTYPE.
RC   STRAIN=NA1000 / CB15N;
RX   PubMed=27028265; DOI=10.1111/mmi.13388;
RA   Meier E.L., Razavi S., Inoue T., Goley E.D.;
RT   "A novel membrane anchor for FtsZ is linked to cell wall hydrolysis in
RT   Caulobacter crescentus.";
RL   Mol. Microbiol. 101:265-280(2016).
CC   -!- FUNCTION: Membrane anchor for FtsZ. Binds and recruits FtsZ polymers to
CC       membranes early in the cell cycle. May also improve the efficiency of
CC       cytokinesis through the regulation of cell wall hydrolysis.
CC       {ECO:0000269|PubMed:27028265}.
CC   -!- SUBUNIT: Interacts with FtsZ filaments. {ECO:0000269|PubMed:20864042,
CC       ECO:0000269|PubMed:27028265}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27028265}. Cell
CC       inner membrane {ECO:0000269|PubMed:27028265}. Note=Associates with
CC       membranes directly (PubMed:27028265). Colocalizes with FtsZ at the
CC       division site (PubMed:20864042). {ECO:0000269|PubMed:20864042,
CC       ECO:0000269|PubMed:27028265}.
CC   -!- DISRUPTION PHENOTYPE: Deletion mutant grows with normal rates,
CC       morphology and Z-ring organization (PubMed:20864042, PubMed:27028265).
CC       In cells lacking other non-essential division genes implicated in cell
CC       wall hydrolysis, such as dipM, ftsE or amiC, deletion of fzlC causes
CC       synthetic cytokinesis defects (PubMed:27028265).
CC       {ECO:0000269|PubMed:20864042, ECO:0000269|PubMed:27028265}.
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DR   EMBL; CP001340; ACL93566.1; -; Genomic_DNA.
DR   RefSeq; WP_010917989.1; NC_011916.1.
DR   RefSeq; YP_002515474.1; NC_011916.1.
DR   AlphaFoldDB; A0A0H3C3S1; -.
DR   SMR; A0A0H3C3S1; -.
DR   EnsemblBacteria; ACL93566; ACL93566; CCNA_00099.
DR   GeneID; 7332353; -.
DR   KEGG; ccs:CCNA_00099; -.
DR   PATRIC; fig|565050.3.peg.98; -.
DR   HOGENOM; CLU_025266_0_0_5; -.
DR   OMA; IDRMMPM; -.
DR   OrthoDB; 442785at2; -.
DR   PhylomeDB; A0A0H3C3S1; -.
DR   Proteomes; UP000001364; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016829; F:lyase activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.50.10.100; -; 1.
DR   InterPro; IPR008929; Chondroitin_lyas.
DR   InterPro; IPR012480; Hepar_II_III.
DR   Pfam; PF07940; Hepar_II_III; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Cell inner membrane; Cell membrane; Cytoplasm;
KW   Membrane; Reference proteome.
FT   CHAIN           1..576
FT                   /note="FtsZ-localized protein C"
FT                   /id="PRO_0000444997"
SQ   SEQUENCE   576 AA;  61333 MW;  4FFD491EEB23F015 CRC64;
     MAGKPPVLGL AFPARLRGGV LWKAIRAEAA GHVEREWFGS GPHRLKIALP RPEGLSARPH
     DPRPVDPAHG QKILSGALTL DGGALRLGVD GDPFDTASPS RRFAVSLHRF DWLPDLVAVG
     PDGARRALRL IDDWRRVFGK WNAFSWGPEC LERRVHHLAC AAKTLAAEAS DAEVADLVFD
     LARQGRHLLE ITRAPERTLE RAVAAGLAGC VLAGKPGEPL IDAALKALVP QLDAMVLGDG
     GHATRSPEAG VELLFDLLTL DDALGQRGRP SPEALSRAID RLSSATRFFI LGDGHLAAFH
     GGETVGPARI AAALAHDDAG PRSLNAAPHS GYHKMIGGSI EVIADCGPPP VGPLSVNACA
     QPAAFEIVCA KDRLITSCGW SPEAAGAHAF RLSDAASTVS VADGSAGRPL SGFRAKALGP
     WLVDGAAKVE AKRHDDVGGV WLDIVHDGWR HLGLTHARRL FLDAVQDELR GEDSLSPLAL
     DPKAAEGPRR YLPFAVRFHL HPDARASIAR DGKSVLIRGP SNIGWWLRND AVDVEIAPSA
     HFDHGLARKA GQIVLKSQVR PEVGAKIRWK LTKAEG