ID   F_HCV1                  Reviewed;         162 AA.
AC   P0C044;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=F protein;
DE   AltName: Full=Alternate reading frame protein/F-protein;
DE            Short=ARFP/F;
DE   AltName: Full=Frameshifted protein;
DE   AltName: Full=p16;
DE   AltName: Full=p17;
OS   Hepatitis C virus genotype 1a (isolate 1) (HCV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC   Amarillovirales; Flaviviridae; Hepacivirus; hepatitis C virus genotype 1a.
OX   NCBI_TaxID=11104;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1848704; DOI=10.1073/pnas.88.6.2451;
RA   Choo Q.-L., Richman K.H., Han J.H., Berger K., Lee C., Dong C.,
RA   Gallegos C., Coit D., Medina-Selby A., Barr P.J., Weiner A.J.,
RA   Bradley D.W., Kuo G., Houghton M.;
RT   "Genetic organization and diversity of the hepatitis C virus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:2451-2455(1991).
RN   [2]
RP   RIBOSOMAL FRAMESHIFT, AND N-TERMINUS.
RX   PubMed=11447125; DOI=10.1093/emboj/20.14.3840;
RA   Xu Z., Choi J., Yen T.S.B., Lu W., Strohecker A., Govindarajan S.,
RA   Chien D., Selby M.J., Ou J.-H.;
RT   "Synthesis of a novel hepatitis C virus protein by ribosomal frameshift.";
RL   EMBO J. 20:3840-3848(2001).
RN   [3]
RP   REVIEW.
RX   PubMed=15732002; DOI=10.1055/s-2005-864786;
RA   Branch A.D., Stump D.D., Gutierrez J.A., Eng F., Walewski J.L.;
RT   "The hepatitis C virus alternate reading frame (ARF) and its family of
RT   novel products: the alternate reading frame protein/F-protein, the double-
RT   frameshift protein, and others.";
RL   Semin. Liver Dis. 25:105-117(2005).
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Host cytoplasm,
CC       host perinuclear region {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=2;
CC         Comment=The exact location of the ribosomal frameshift is unknown.
CC         The F protein seems to be generated by a -2 ribosomal frameshift
CC         located in the vicinity of codon 11 of the core protein coding
CC         sequence. However, some F proteins may also be generated by +1
CC         ribosomal frameshift. Since the core gene encodes alternative reading
CC         frame proteins (ARFPs), many functions depicted for the core protein
CC         might belong to the ARFPs. {ECO:0000269|PubMed:11447125};
CC       Name=F protein; Synonyms=Frameshifted protein;
CC         IsoId=P0C044-1; Sequence=Displayed;
CC       Name=Genome polyprotein;
CC         IsoId=P26664-1; Sequence=External;
CC   -!- MISCELLANEOUS: This protein is very unstable. {ECO:0000250}.
CC   -!- MISCELLANEOUS: [Isoform F protein]: Produced by ribosomal
CC       frameshifting.
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DR   EMBL; M62321; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   euHCVdb; M62321; -.
DR   Proteomes; UP000007410; Genome.
DR   GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR002522; HCV_core_N.
DR   Pfam; PF01543; HCV_capsid; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Ribosomal frameshifting.
FT   INIT_MET        1
FT                   /note="Removed; by host"
FT                   /evidence="ECO:0000305"
FT   CHAIN           2..162
FT                   /note="F protein"
FT                   /id="PRO_0000109552"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   162 AA;  17002 MW;  3DAD4DE1E4312A7A CRC64;
     MSTNPKPQKK KTNVTPTVAH RTSSSRVAVR SLVEFTCCRA GALDWVCARR ERLPSGRNLE
     VDVSLSPRLV GPRAGPGLSP GTLGPSMAMR AAGGRDGSCL PVALGLAGAP QTPGVGRAIW
     VRSSIPLRAA SPTSWGTYRS SAPLLEALPG PWRMASGFWK TA