ID   G0S2_MOUSE              Reviewed;         103 AA.
AC   Q61585;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=G0/G1 switch protein 2;
DE   AltName: Full=G0S2-like protein;
GN   Name=G0s2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Ahrens M., Schroeder D., Gross G.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RA   Kay M.;
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Promotes apoptosis by binding to BCL2, hence preventing the
CC       formation of protective BCL2-BAX heterodimers. {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with BCL2; this interaction prevents the
CC       formation of the anti-apoptotic BAX-BCL2 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
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DR   EMBL; X95280; CAA64601.1; -; mRNA.
DR   EMBL; AL365314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS15636.1; -.
DR   RefSeq; NP_032085.1; NM_008059.3.
DR   AlphaFoldDB; Q61585; -.
DR   BioGRID; 199784; 1.
DR   DIP; DIP-61640N; -.
DR   IntAct; Q61585; 1.
DR   STRING; 10090.ENSMUSP00000009777; -.
DR   iPTMnet; Q61585; -.
DR   PhosphoSitePlus; Q61585; -.
DR   MaxQB; Q61585; -.
DR   PaxDb; Q61585; -.
DR   PRIDE; Q61585; -.
DR   ProteomicsDB; 271622; -.
DR   Antibodypedia; 2397; 144 antibodies from 24 providers.
DR   DNASU; 14373; -.
DR   Ensembl; ENSMUST00000009777; ENSMUSP00000009777; ENSMUSG00000009633.
DR   GeneID; 14373; -.
DR   KEGG; mmu:14373; -.
DR   UCSC; uc007eei.2; mouse.
DR   CTD; 50486; -.
DR   MGI; MGI:1316737; G0s2.
DR   VEuPathDB; HostDB:ENSMUSG00000009633; -.
DR   eggNOG; ENOG502S7WP; Eukaryota.
DR   GeneTree; ENSGT00390000005294; -.
DR   HOGENOM; CLU_138623_0_0_1; -.
DR   InParanoid; Q61585; -.
DR   OMA; ANRQHAS; -.
DR   OrthoDB; 1486241at2759; -.
DR   PhylomeDB; Q61585; -.
DR   TreeFam; TF336218; -.
DR   BioGRID-ORCS; 14373; 1 hit in 71 CRISPR screens.
DR   ChiTaRS; G0s2; mouse.
DR   PRO; PR:Q61585; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q61585; protein.
DR   Bgee; ENSMUSG00000009633; Expressed in granulocyte and 237 other tissues.
DR   ExpressionAtlas; Q61585; baseline and differential.
DR   Genevisible; Q61585; MM.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISS:UniProtKB.
DR   GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IMP:YuBioLab.
DR   GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR016821; G0S2.
DR   PANTHER; PTHR15570; PTHR15570; 1.
DR   Pfam; PF15103; G0-G1_switch_2; 1.
DR   PIRSF; PIRSF023925; G0/G1_switch_p2; 1.
PE   1: Evidence at protein level;
KW   Apoptosis; Mitochondrion; Reference proteome.
FT   CHAIN           1..103
FT                   /note="G0/G1 switch protein 2"
FT                   /id="PRO_0000087406"
SQ   SEQUENCE   103 AA;  11118 MW;  0205A24D69C33BB5 CRC64;
     MESVQELIPL AKEMMAQKPR GKLVKLYVLG SVLALFGVVL GLVETVCSPF TAASRLRDQE
     AAVVELREAC EQQSLHKQAL LAGGKAQEAT LCSRALSLRQ HAS