ID   G0S2_RAT                Reviewed;         103 AA.
AC   Q5M840;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=G0/G1 switch protein 2;
DE   AltName: Full=G0S2-like protein;
GN   Name=G0s2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Promotes apoptosis by binding to BCL2, hence preventing the
CC       formation of protective BCL2-BAX heterodimers. {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with BCL2; this interaction prevents the
CC       formation of the anti-apoptotic BAX-BCL2 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
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DR   EMBL; CH473985; EDL95033.1; -; Genomic_DNA.
DR   EMBL; BC088248; AAH88248.1; -; mRNA.
DR   RefSeq; NP_001009632.1; NM_001009632.1.
DR   AlphaFoldDB; Q5M840; -.
DR   STRING; 10116.ENSRNOP00000007879; -.
DR   PaxDb; Q5M840; -.
DR   Ensembl; ENSRNOT00000007879; ENSRNOP00000007879; ENSRNOG00000006019.
DR   GeneID; 289388; -.
DR   KEGG; rno:289388; -.
DR   CTD; 50486; -.
DR   RGD; 1311675; G0s2.
DR   eggNOG; ENOG502S7WP; Eukaryota.
DR   GeneTree; ENSGT00390000005294; -.
DR   HOGENOM; CLU_138623_0_0_1; -.
DR   InParanoid; Q5M840; -.
DR   OMA; ANRQHAS; -.
DR   OrthoDB; 1486241at2759; -.
DR   PhylomeDB; Q5M840; -.
DR   TreeFam; TF336218; -.
DR   PRO; PR:Q5M840; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Proteomes; UP000234681; Chromosome 13.
DR   Bgee; ENSRNOG00000006019; Expressed in liver and 19 other tissues.
DR   Genevisible; Q5M840; RN.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISS:UniProtKB.
DR   GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; ISS:YuBioLab.
DR   GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR016821; G0S2.
DR   PANTHER; PTHR15570; PTHR15570; 1.
DR   Pfam; PF15103; G0-G1_switch_2; 1.
DR   PIRSF; PIRSF023925; G0/G1_switch_p2; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Cell cycle; Mitochondrion; Reference proteome.
FT   CHAIN           1..103
FT                   /note="G0/G1 switch protein 2"
FT                   /id="PRO_0000416594"
SQ   SEQUENCE   103 AA;  11232 MW;  B921FAB9D9AB709A CRC64;
     MESVQELIPL AKEMMTQKSR GKLVKLYVLG SVLAFFGVVL GLVETVCSPF TAASRLRDQE
     AAVAELRDAC EQQSLHKQAL IAEGKTQEAT LCSRALSLRQ HAS