ID   G137A_BOVIN             Reviewed;         395 AA.
AC   Q17QQ5;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Integral membrane protein GPR137;
GN   Name=GPR137;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Lysosomal integral membrane protein that may regulate MTORC1
CC       complex translocation to lysosomes. May play a role in autophagy.
CC       {ECO:0000250|UniProtKB:Q96N19}.
CC   -!- FUNCTION: May activate Wnt/beta-catenin signaling to modulate
CC       epithelial cell function. {ECO:0000250|UniProtKB:Q80ZU9}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96N19};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the GPR137 family. {ECO:0000305}.
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DR   EMBL; BC118235; AAI18236.2; -; mRNA.
DR   RefSeq; NP_001106766.1; NM_001113295.1.
DR   RefSeq; XP_010819359.1; XM_010821057.2.
DR   AlphaFoldDB; Q17QQ5; -.
DR   STRING; 9913.ENSBTAP00000030100; -.
DR   PaxDb; Q17QQ5; -.
DR   Ensembl; ENSBTAT00000030114; ENSBTAP00000030100; ENSBTAG00000012512.
DR   GeneID; 505015; -.
DR   KEGG; bta:505015; -.
DR   CTD; 56834; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012512; -.
DR   VGNC; VGNC:29550; GPR137.
DR   eggNOG; ENOG502QQ83; Eukaryota.
DR   GeneTree; ENSGT00940000153986; -.
DR   HOGENOM; CLU_050057_0_0_1; -.
DR   InParanoid; Q17QQ5; -.
DR   OrthoDB; 1399303at2759; -.
DR   TreeFam; TF329003; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000012512; Expressed in temporal cortex and 107 other tissues.
DR   ExpressionAtlas; Q17QQ5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0045779; P:negative regulation of bone resorption; IBA:GO_Central.
DR   GO; GO:0045671; P:negative regulation of osteoclast differentiation; IBA:GO_Central.
DR   GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR   GO; GO:0010506; P:regulation of autophagy; IBA:GO_Central.
DR   GO; GO:0046850; P:regulation of bone remodeling; IMP:UniProtKB.
DR   GO; GO:0045124; P:regulation of bone resorption; IMP:UniProtKB.
DR   GO; GO:0030278; P:regulation of ossification; IMP:UniProtKB.
DR   InterPro; IPR029723; GPR137.
DR   PANTHER; PTHR15146; PTHR15146; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Glycoprotein; Lysosome; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..395
FT                   /note="Integral membrane protein GPR137"
FT                   /id="PRO_0000269995"
FT   TOPO_DOM        1..31
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        32..52
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..60
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        61..81
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        82..89
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        90..110
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        111..140
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        141..161
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..175
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        176..196
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        197..222
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        223..243
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        244..274
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        275..295
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        296..395
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        257
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   395 AA;  43596 MW;  9F80B7ADC09ABFE0 CRC64;
     MESNLSGLVP AAGLVPALPP AVTLGLTAAY TTLYALLFFS VYAQLWLVLL YGHKRLSYQT
     VFLALCLLWA ALRTTLFSFY FRDTPRANHL GPLPFWLLYC CPVCLQFFTL TLMNLYFAQV
     VFKAKAKRRP EMSRGLLAVR GAFVGASLLF LLVNVLCAML SRRRRAQPWA LLLVRVLVSD
     SLFVICALSL AACLCLVARR APSTSIYLEA KGTSVCQAAA MGGAMVLLYA SRACYNLAAL
     ALAPRSRLDA FDYDWYNVSD QADLVNDLGN KGYLVFGLIL FVWELLPTTL LVGFFRVHRP
     PQDLSTSRIL NGQVFGSRSY FFDRAHCEDE GCSWEHSRGE STSMSGSLGS SSWYGTIGRE
     PGWCGGSQTR TTPLLFSQVL GPGGHHHSLY STPQT