G137A_MOUSE
ID G137A_MOUSE Reviewed; 396 AA.
AC Q80ZU9; Q80UB6;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Integral membrane protein GPR137;
DE AltName: Full=Transmembrane 7 superfamily member 1-like 1 protein;
GN Name=Gpr137; Synonyms=Tm7sf1l1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-86.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [3]
RP FUNCTION.
RX PubMed=28975893; DOI=10.7554/elife.28366;
RA Mager L.F., Koelzer V.H., Stuber R., Thoo L., Keller I., Koeck I.,
RA Langenegger M., Simillion C., Pfister S.P., Faderl M., Genitsch V.,
RA Tcymbarevich I., Juillerat P., Li X., Xia Y., Karamitopoulou E., Lyck R.,
RA Zlobec I., Hapfelmeier S., Bruggmann R., McCoy K.D., Macpherson A.J.,
RA Mueller C., Beutler B., Krebs P.;
RT "The ESRP1-GPR137 axis contributes to intestinal pathogenesis.";
RL Elife 6:0-0(2017).
CC -!- FUNCTION: Lysosomal integral membrane protein that may regulate MTORC1
CC complex translocation to lysosomes. May play a role in autophagy.
CC {ECO:0000250|UniProtKB:Q96N19}.
CC -!- FUNCTION: May activate Wnt/beta-catenin signaling to modulate
CC epithelial cell function. {ECO:0000269|PubMed:28975893}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96N19};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the GPR137 family. {ECO:0000305}.
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DR EMBL; BC048078; AAH48078.1; -; mRNA.
DR EMBL; AY255566; AAO85078.1; -; mRNA.
DR CCDS; CCDS29512.1; -.
DR RefSeq; NP_001170831.1; NM_001177360.1.
DR RefSeq; NP_997103.1; NM_207220.2.
DR AlphaFoldDB; Q80ZU9; -.
DR STRING; 10090.ENSMUSP00000130969; -.
DR GlyGen; Q80ZU9; 2 sites.
DR iPTMnet; Q80ZU9; -.
DR PhosphoSitePlus; Q80ZU9; -.
DR MaxQB; Q80ZU9; -.
DR PaxDb; Q80ZU9; -.
DR PRIDE; Q80ZU9; -.
DR ProteomicsDB; 273402; -.
DR Antibodypedia; 15349; 194 antibodies from 24 providers.
DR Ensembl; ENSMUST00000025909; ENSMUSP00000025909; ENSMUSG00000024958.
DR Ensembl; ENSMUST00000166115; ENSMUSP00000130969; ENSMUSG00000024958.
DR Ensembl; ENSMUST00000237934; ENSMUSP00000158264; ENSMUSG00000024958.
DR GeneID; 107173; -.
DR KEGG; mmu:107173; -.
DR UCSC; uc008gjk.2; mouse.
DR CTD; 56834; -.
DR MGI; MGI:2147529; Gpr137.
DR VEuPathDB; HostDB:ENSMUSG00000024958; -.
DR eggNOG; ENOG502QQ83; Eukaryota.
DR GeneTree; ENSGT00940000153986; -.
DR InParanoid; Q80ZU9; -.
DR OMA; RSYFFDH; -.
DR OrthoDB; 1399303at2759; -.
DR PhylomeDB; Q80ZU9; -.
DR TreeFam; TF329003; -.
DR BioGRID-ORCS; 107173; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q80ZU9; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q80ZU9; protein.
DR Bgee; ENSMUSG00000024958; Expressed in primary visual cortex and 201 other tissues.
DR ExpressionAtlas; Q80ZU9; baseline and differential.
DR Genevisible; Q80ZU9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0045779; P:negative regulation of bone resorption; IBA:GO_Central.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; IBA:GO_Central.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:0010506; P:regulation of autophagy; IBA:GO_Central.
DR InterPro; IPR029723; GPR137.
DR PANTHER; PTHR15146; PTHR15146; 1.
PE 2: Evidence at transcript level;
KW Autophagy; Glycoprotein; Lysosome; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..396
FT /note="Integral membrane protein GPR137"
FT /id="PRO_0000269997"
FT TOPO_DOM 1..31
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..89
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 90..110
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..175
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 176..196
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..217
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 218..242
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 243..274
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..396
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 257
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 396 AA; 43574 MW; 4CA45B03848952BF CRC64;
MESNLSGLVP AAGLVPALPP TVTLGLTAAY TALYALLFFS VYAQLWLVLL YGHKRLSYQT
VFLALCLLWA ALRTTLFSFY FRDTPRANRL GPLPFWLLYC CPVCLQFFTL TLMNLYFVQV
VFKAKAKRRP EMSRGLLAVR GAFVGASLLF LLVNVLCAVL SRQRQAQPWV LLLVRVLVSD
SLFVICALSL AACLCLVARR APSTSIYLEA KGTSVCQAAA IGGAMVLLYA SRACYNLAAL
ALAPRSRLDA FDYDWYNVSD QADLVNDLGN KGYLVFGLIL FVWELLPTTL LVGFFRVHRP
PQDLSTSRIL NGQVFGSRSY FFDRAGHCED EGCSWEHSRS ESTSMSGSLG SGSWYGAIGR
EPGWGGASQT RTTPLLFSQV PGPGSHHHSL YSTPQT
